prof. dr. J.H. (Joke) de Boer
prof. dr. J.H. (Joke) de Boer
Research Programs
Biography
Biography
Prof.dr. Joke de Boer is an ophthalmologist and acknowledged expert in inflammatory eye diseases with a special interest in noninfectious and infectious uveitis in adults and children. Noninfectious uveitis is a vision-threatening chronic, progressive inflammation of the interior eye. Current treatment strategies with immunosuppressive medications may fail to prevent the decline in visual function. Her research focusses on the underlying pathogenesis of noninfectious uveitis and development of new treatment strategies for this blinding disease in collaboration with the Laboratory of Translational Immunology. To this end, she uses the ‘Systems Medicine’ approach that combines in-depth phenotyping of the peripheral immune-compartment of patients and computational modeling of the derived high-throughput data to reveal the true perpetrating epigenetic mechanisms that drive noninfectious uveitis. The nature of this approach makes it very well suited for identifying novel biomarkers to improve treatment and disease outcome in patients with noninfectious uveitis in the near future. Other research topics are aqueous humor analysis in infectious uveitis in collaboration with the virology section of the department of medical microbiology . Joke de Boer is member of the International Uveitis Study Group, the national guideline committee for uveitis and the European guideline committee for uveitis associated with juvenile idiopathic arthritis.
Side Activities
Member of the International Uveitis Study Group
Member of the European paediatric ophthalmology society
Member of the Dutch Ophthalmology society
Member of the Dutch uveitis study group
Member of the Multinational Interdisciplinary working group of uveitis in children
Member of the Dutch "kennis agenda"of ophthalology
Member of James Lind aliance of Juvenile idiopathic artritis
Chair of addendum biologicals of the Dutch guideline of uveitis
Chair Quality committee Dutch Ophthalmology society
Board member of uveitis guideline committee Dutch Ophthalmology society
Member of the Fluorescein Angiography Netherlands club.
Member of the Dutch pediatric ophthalmology study group
Member of the European guideline committee for uveitis associated with juvenile idiopathic arthritis
Host of the international uveitis symposium ISU 2022, Utrecht, the Netherlands
Fellowship and Awards
1994 AER Montpellier, best paper award for “Low mature TGF-â2 in aqueous humour during uveitis”.
2011 ODAS price for paediatric ophthalmology
2011 The Clinical Uveitis Research Award from the European Uveitis Patient Interest Association
Research Output (152)
Moekotte Lude, Kuiper Jonas J.W., Hiddingh Sanne, Nguyen Xuan Thanh An, Boon Camiel J.F., van den Born L. Ingeborgh, de Boer Joke H., van Genderen Maria M. 3 Oct 2023, In: Investigative Ophthalmology and Visual Science. 64
Kouwenberg Carlyn V., Spierings Julia, de Groot Evianne L., de Boer Joke H., Kalinina Ayuso Viera 2 Oct 2023, In: Pediatric rheumatology online journal. 21 , p. 1-9 9 p.
Kouwenberg Carlyn V., Blom Laurens A., Vellinga Suzanne C., Bozkir Irem, de Boer Joke H., Ayuso Viera Koopman Kalinina Oct 2023, In: American Journal of Ophthalmology. 254 , p. 62-68 7 p.
Chiriboga Claudia A., Bruno Claudio, Duong Tina, Fischer Dirk, Mercuri Eugenio, Kirschner Janbernd, Kostera-Pruszczyk Anna, Jaber Birgit, Gorni Ksenija, Kletzl Heidemarie, Carruthers Imogen, Martin Carmen, Warren Francis, Scalco Renata S., Wagner Kathryn R., Muntoni Francesco, Deconinck Nicolas, Balikova Irina, Joniau Inge, Tahon Valentine, Wittevrongel Sylvia, Goemans Nathalie, Cassiman Catherine, Prove Lies, Vancampenhout Lisa, van den Hauwe Marleen, Van Impe Annelies, Cances Claude, Soler Vincent, De La Morandais Lauriane Maillard, Vovan Delphine, Cintas Pascal, Auriol Françoise, Mus Marianne, Alphonsa Gwennaelle, Bellio Valerie, Gil Mato Olaia, Flamein Florence, Evrard Cécile, Ziouche Amina, Bouacha-Allou Ikram, Debruyne Philippe, Derlyn Gilles, Defoort Sabine, Leroy Florian, Van der Pol Ludo, de Boer Joke, Imhof Saskia, Ruyten Thijs, Van Der Woude Danny, Oct 2023, In: Neurology and Therapy. 12 , p. 1799-1801 3 p.
de Groot Evianne L., Ossewaarde-van Norel Jeannette, de Boer Joke H., Hiddingh Sanne, Bakker Bjorn, van Huet Ramon A.C., Ten Dam-van Loon Ninette H., Thiadens Alberta A.H.J., Meester-Smoor Magda A., de Jong-Hesse Yvonne, Los Leonoor I., den Hollander Anneke I., Boon Camiel J.F., Kiemeney Lambertus A., van Eijk Kristel R., Bakker Mark K., Hoyng Carel B., Kuiper Jonas J.W. 17 Aug 2023, In: JAMA ophthalmology. 141 , p. 737-745 9 p.
de Groot Evianne L., ten Dam-van Loon Ninette H., Kouwenberg Carlyn V., de Boer Joke H., Ossewaarde-van Norel Jeannette Aug 2023, In: American Journal of Ophthalmology. 252 , p. 45-58 14 p.
Ohm Milou, van Straalen Joeri W, de Joode-Smink Gerrie, van Montfrans Joris, Bartels Marije, van Wildenbeest Joanne G, Lindemans Caroline A, Wennink Roos Aw, de Boer Joke H, Sanders Elisabeth Am, Verduyn-Lunel Frans M, Berbers Guy Am, Wulffraat Nico M, Jansen Marc H A 20 Jul 2023, In: Pediatric rheumatology online journal. 21 , p. 1-6
Ohm Milou, van Straalen Joeri W, Zijlstra Marieke, de Joode-Smink Gerrie, Jasmijn Sellies Anne, Swart Joost F, Vastert Sebastiaan J, van Montfrans Joris M, Bartels Marije, van Royen-Kerkhof Annet, Wildenbeest Joanne G, Lindemans Caroline A, Wolters Victorien, Wennink Roos A W, de Boer Joke H, Knol Mirjam J, Heijstek Marloes W, Sanders Elisabeth A M, Verduyn-Lunel Frans M, Berbers Guy A M, Wulffraat Nico M, Jansen Marc H A 15 May 2023, In: Vaccine. 41 , p. 3782-3789 8 p.
Hiddingh S., Pandit A., Verhagen F. H., Rijken R., Servaas N. H., Wichers C. G.K., Ten Dam-Van Loon N. H., Imhof S. M., Radstake T. R.D.J., de Boer J. H., Kuiper J. J.W. 12 Apr 2023, In: eLife. 12
van Straalen Joeri W, Akay Görkem, Kouwenberg Carlyn V, de Roock Sytze, Kalinina Ayuso Viera, Wulffraat Nico M, de Boer Joke, Swart Joost F Apr 2023, In: RMD Open. 9 , p. 1-8