Infection and Immunity nieuws
Infection and Immunity nieuws
May 29: Unveiling the mysteries of smell: research on COVID-19-related smell loss
During the COVID-19 pandemic – especially during the first wave of infections- a large number of people infected with the SARS-CoV-2 virus reported a sudden loss of smell. Dutch investigators quickly set up a series of studies on diagnosis, pathophysiology, epidemiology, clinical course and treatment of COVID-19-induced loss of smell. The PhD thesis by Emma Schepens (UMC Utrecht) provides some interesting and valuable insights on this unexpected clinical finding.
Read moreMay 27: New research provides further evidence that pediatric uveitis is a systemic immune disease
Pediatric uveitis might be a manifestation of a disease that affects not only the eye but also the systemic immune system and microcirculation. Therefore, it is important to adopt a multidisciplinary approach in the management of pediatric uveitis patients to provide the best possible care. These were the main takeaways from the PhD research by Carlyn Kouwenberg from UMC Utrecht.
Read moreAlternatives to antibiotics: Adapting phages to overcome bacterial defense barriers
Collaborating researchers from University Medical Center Utrecht and Delft University of Technology have received funding from the Dutch Research Council (NWO) to develop more broadly acting bacteriophages. With help of such adapted phages, the researchers want to overcome bacterial defense barriers, which are important mechanisms in the bacterial resistance against bacteriophages.
Read moreStudy of new treatment for severe influenza pneumonia
Van elke vijf patiënten die met ernstige longontsteking door influenza op de intensive care (IC) worden opgenomen, overlijdt er gemiddeld één. Om dit relatief hoge risico op overlijden te verlagen, gaan Nederlandse onderzoekers onder leiding van UMC Utrecht geneesmiddelen die eerder succesvol waren bij de behandeling van patiënten met ernstige Covid-19 op de IC terecht kwamen, nu ook onderzoeken bij IC-patiënten met ernstige longontsteking door influenza. ZonMw heeft voor deze studie een subsidie van ruim € 2.1 miljoen beschikbaar gesteld.
Read moreApr 23: Existing drugs now available in study for patients with rare immune diseases
This DRIMID study will investigate the efficacy and safety of the drug filgotinib (approved for treatment of rheumatoid arthritis and ulcerative colitis) in three rare immune diseases (Behçet's disease, idiopathic inflammatory myositis, IgG4-related disease)
Read moreApr 15: "The Next Step" - Jeanette Leusen's inaugural lecture
On Tuesday, April 9, 2024, Jeanette Leusen, professor of Antibody Therapy at Utrecht University and UMC Utrecht, delivered her inaugural lecture. There she addressed the discovery, development and clinical application of antibodies. Partly due to the research of Jeanette and her group, antibodies based on immunoglobulin A (IgA) also appear to have great potential as a next generation treatment option in cancer, and perhaps also in infectious diseases. A first drug candidate is now ready for the next step: a ‘first-in-human’ study, but this will require more investment.
Read moreApr 8: British GPs too often write repeat prescriptions for antibiotics for respiratory infections
Research into repeat prescriptions for antibiotics for respiratory infections by GPs has shown that they are widely prescribed in the UK, despite evidence that they provide little benefit to the patient. Researchers (from the universities of Bristol and Bath, King's College London and UMC Utrecht) are therefore calling for repeat prescriptions to be reduced and that they are specifically targeted in interventions to promote rational antibiotic use.
Read moreApr 3: In vitro studies for a better understanding of bacteriophage-bacteria interactions
PhD research by Julia Egido Egido (UMC Utrecht) has shown in in vitro studies that bacteriophages may act synergistically with certain antibiotics to kill bacteria. On the other hand, she found that the human complement system can inhibit certain phages in vitro which may compromise their antibacterial activity. These findings provide new insights that are helpful in the development of phage therapy.
Read moreFocus on side effects of immunotherapy
More research into the side effects of immunotherapy for cancer is highly needed. That is the message of researchers from Utrecht with their article in the journal Nature Cancer. These side effects vary widely, from skin rashes to inflammation of the heart. Focus on side effects of immunotherapy
Read moreFeb 29: One Health project to predict antimicrobial resistance in low-income setting awarded with ZonMw grant
Together with international partners from high- and low-resource settings, epidemiologist Esther van Kleef PhD (Epidemiology of Infectious Diseases, UMC Utrecht and Institute of Tropical Medicine, Antwerp) has received a JPIAMR grant of € 1.9 million to develop a low-cost surveillance approach to monitor antimicrobial resistance (AMR) outside the hospital setting in sub-Saharan Africa and predict AMR in clinical infections. This project is pioneering the use of metagenomics, which examines DNA from bacteria in pooled fecal samples to predict which antibiotics are still effective against serious infections.
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