prof. dr. J.C. (Hans) Clevers

Full Professor

  • Molecular Cancer Research
  • Hubrecht Institute

prof. dr. J.C. (Hans) Clevers


Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). His research group is part of the Hubrecht institute.

He is Chevalier de la Legion d'Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

Side Activities

  • Honorary professorship:

    2002 –  Honorary professor at Changsha-Hunan, China



    Member European Molecular Biology Organisation (EMBO)

    Member of the Royal Netherlands Academy of Sciences

    Member of the International Society for Stem Cell Research (ISSCR)

    Member of the Scientific Advisory Board of ISREC, Swiss Institute for Experimental Cancer Research

    Member Scientific Committee of the Louis-Jeantet Foundation for Medicine

    Member of the American Association for Cancer Research (AACR)

    Member of the National Scientific Advisory Board NKI-AVL

    Member of the scientific advisory board of “de Anatomische Les”

    Member of the Academia Europaea

    Member of the Scientific Advisory Board of the MRC Clinical Sciences Centre

    Member of the American Academy of Arts and Sciences

    Member of the The Royal Holland Society of Sciences and Humanities

    Member of the Gairdner Foundation medical advisory board

    Foreign Associate of the US National Academy of Sciences

    Member of the Scientific advisory committee (SAC) of the Princess Máxima Center for Pediatric Oncology


    He is member of a several Editorial Boards, among them are the EMBO Journal, Gastroenterology, Cell and Genes & Development,Cell Stem Cell and the Annual Review of Cancer Biology

Fellowship and Awards

  • 2000     Catharijne-prize for medical science

    2001     Award from the European Society for Clinical Investigation

    2001     Spinoza-award

    2004     Louis-Jeantet Prize for Medicine

    2005     The Science and Society Prize

    2005     The French honor of “Chevalier de la Legion d'Honneur”

    2005     Katharine Berkan Judd Award

    2006     Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research

    2008     Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam)

    2008     Meyenburg Cancer Research Award

    2009     The Queen Wilhelmina Dutch Cancer Society Award

    2010     The United European Gastroenterology Federation (UEGF) Research Prize

    2011     The Ernst Jung Medical Award

    2011     Kolff prize

    2012     Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize

    2012     William Beaumont prize of the American Gastroenterology Association

    2012     The Heineken Prize for Medicine

    2012     Ridder in de Orde van de Nederlandse Leeuw

    2013     The Breakthrough Prize in Life Sciences

    2014     Massachusetts General Hospital Award in Cancer Research

    2014     TEFAF Oncology Chair 2014

    2014     Fellow of the AACR Academy

    2014     Struyvenberg European Society for Clinical Investigation (ESCI) medal

    2014     National Icon 2014

Research Output (517)

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids

Dekkers Johanna F., Whittle James R., Vaillant François, Chen Huei Rong, Dawson Caleb, Liu Kevin, Geurts Maarten H., Herold Marco J., Clevers Hans, Lindeman Geoffrey J., Visvader Jane E. 1 mei 2020, In: Journal of the National Cancer Institute. 112 , p. 540-544 5 p.

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

Rosenbluth Jennifer M, Schackmann Ron C J, Gray G Kenneth, Selfors Laura M, Li Carman Man-Chung, Boedicker Mackenzie, Kuiken Hendrik J, Richardson Andrea, Brock Jane, Garber Judy, Dillon Deborah, Sachs Norman, Clevers Hans, Brugge Joan S 6 apr 2020, In: Nature Communications. 11 14 p.

The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies

Busslinger Georg A, Lissendorp Fianne, Franken Ingrid A, van Hillegersberg Richard, Ruurda Jelle P, Clevers Hans, de Maat Michiel F G apr 2020, In: Open Biology. 10 6 p.

On Stem Cells, Organoids and Human Disease

Clevers Hans 1 feb 2020, In: European Review. 28 , p. 1-5 5 p.

Snake Venom Gland Organoids

Post Yorick, Puschhof Jens, Beumer Joep, Kerkkamp Harald M., de Bakker Merijn A.G., Slagboom Julien, de Barbanson Buys, Wevers Nienke R., Spijkers Xandor M., Olivier Thomas, Kazandjian Taline D., Ainsworth Stuart, Iglesias Carmen Lopez, van de Wetering Willine J., Heinz Maria C., van Ineveld Ravian L., van Kleef Regina G.D.M., Begthel Harry, Korving Jeroen, Bar-Ephraim Yotam E., Getreuer Walter, Rios Anne C., Westerink Remco H.S., Snippert Hugo J.G., van Oudenaarden Alexander, Peters Peter J., Vonk Freek J., Kool Jeroen, Richardson Michael K., Casewell Nicholas R., Clevers Hans 23 jan 2020, In: Cell. 180 , p. 233-247.e21

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Yao Ye, Xu Xiaoya, Yang Lifeng, Zhu Ji, Wan Juefeng, Shen Lijun, Xia Fan, Fu Guoxiang, Deng Yun, Pan Mengxue, Guo Qiang, Gao Xiaoxue, Li Yuanchuang, Rao Xinxin, Zhou Yi, Liang Liping, Wang Yaqi, Zhang Jing, Zhang Hui, Li Guichao, Zhang Lixing, Peng Junjie, Cai Sanjun, Hu Chen, Gao Jianjun, Clevers Hans, Zhang Zhen, Hua Guoqiang 2 jan 2020, In: Cell Stem Cell. 26 , p. 17-26.e6 16 p.

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

Van Es Johan H., Wiebrands Kay, López-Iglesias Carmen, Van De Wetering Marc, Zeinstra Laura, Van Den Born Maaike, Korving Jeroen, Sasaki Nobuo, Peters Peter J., Van Oudenaarden Alexander, Clevers Hans 26 dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116 , p. 26599-26605 7 p.

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

Driehuis Else, Van Hoeck Arne, Moore Kat, Kolders Sigrid, Francies Hayley E., Gulersonmez M. Can, Stigter Edwin C.A., Burgering Boudewijn, Geurts Veerle, Gracanin Ana, Bounova Gergana, Morsink Folkert H., Vries Robert, Boj Sylvia, Van Es Johan, Offerhaus G. Johan A., Kranenburg Onno, Garnett Mathew J., Wessels Lodewyk, Cuppen Edwin, Brosens Lodewijk A.A., Clevers Hans 9 dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116 , p. 26580-26590 11 p.

IFN-γ:The T cell's license to kill stem cells in the inflamed intestine

Kretzschmar Kai, Clevers Hans 6 dec 2019, In: Science Immunology. 4 2 p.

Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

Giobbe Giovanni Giuseppe, Crowley Claire, Luni Camilla, Campinoti Sara, Khedr Moustafa, Kretzschmar Kai, De Santis Martina Maria, Zambaiti Elisa, Michielin Federica, Meran Laween, Hu Qianjiang, van Son Gijs, Urbani Luca, Manfredi Anna, Giomo Monica, Eaton Simon, Cacchiarelli Davide, Li Vivian S.W., Clevers Hans, Bonfanti Paola, Elvassore Nicola, De Coppi Paolo 1 dec 2019, In: Nature Communications. 10

All Research Output (517)