dr. S.G. (Sjoerd) Elias

Associate Professor

  • Department of Epidemiology
  • Julius Center Research Program Cancer
  • Julius Center Research Program Cancer

dr. S.G. (Sjoerd) Elias

Research Programs


I obtained my MSc in Clinical Epidemiology (2002) at the Netherlands Institute for Health Sciences, and my PhD at Utrecht University (2003). Following graduation from Medical School in 2005 I worked as a resident in radiology (Gelre Ziekenhuizen Apeldoorn, the Netherlands, 2006-2007). A personal Dutch Cancer Society Research Fellowship (2009-2013) enabled me to work as a visiting scientist at the Molecular Imaging Program at Stanford (professor SS Gambhir), the Department of Radiology and Biomedical Imaging at the University of California San Francisco (professor NM Hylton), and the Department of Molecular Pathology at the Netherlands Cancer Institute (professor LJ van't Veer). Since 2008, I work as a Clinical Epidemiologist in the research programs Cancer and Methodology at the Julius Center for Health Sciences and Primary Care, since 2018 as Associate Professor. Furthermore, I teach several courses in clinical epidemiology, both nationally as well as internationally.

Interests and Focus

My main research focus is on the clinical evaluation and translation of biomarkers, particularly for cancer classification (i.e. diagnostic, prognostic, and predictive markers). These markers include emerging imaging technologies such as molecular imaging, omics-based tests, and organoids. I have both experience in preclinical research as well as applied clinical science, and have expertise in the design and analysis of studies spanning all (translation) phases of biomarker development.

Side Activities

  • Advisor to the scientific counsel of PLCRC (Prospectief Landelijk CRC cohort).
    Member of BOOG (the Dutch breast cancer research group).
    Methodological member of the IRB (Medisch Etische Toetsings Commissie) of UMC Utrecht.
    Member of the Dutch Association for Epidemiology (Vereniging voor Epidemiologie), Registration as Senior Epidemiologist (B) (SMBWO, 2006).

Fellowship and Awards

  • 2014: Epidemiology teacher of the year, Epidemiology department, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht.
    2014: Voted best lecturer of the year by the Selective Utrecht Medical Master program students, Utrecht University.
    2013: UMC Utrecht Research Talent Program.
    2012: Invitee, 2nd Inspire2Live annual conference at the Royal Netherlands Academy of Arts and Sciences (meeting of talented young international cancer scientists).
    2011: René Vogels Foundation travel grant.
    2009: Dutch Cancer Society Research Fellowship (four year personal grant).

Research Output (144)

[Zr-89]Zr-cetuximab PET/CT as biomarker for cetuximab monotherapy in patients with RAS wild-type advanced colorectal cancer

van Helden E J, Elias S G, Gerritse S L, van Es S C, Boon E, Huisman M C, van Grieken N C T, Dekker H, van Dongen G A M S, Vugts D J, Boellaard R, van Herpen C M L, de Vries E G E, Oyen W J G, Brouwers A H, Verheul H M W, Hoekstra O S, Menke-van der Houven van Oordt C W apr 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47 , p. 849-859 11 p.

Tumor Seeding During Colonoscopy as a Possible Cause for Metachronous Colorectal Cancer

Backes Yara, Seerden Tom C.J., van Gestel Rosanne S.F.E., Kranenburg Onno, Ubink Inge, Schiffelers Raymond M., van Straten Demian, van der Capellen Malu S., van de Weerd Simone, de Leng Wendy W.J., Siersema Peter D., Offerhaus G. Johan A., Morsink Folkert H., Ramphal Winesh, Terhaar Sive Droste Jochiim, van Lent Anja U.G., Geesing Joost M.J., Vleggaar Frank P., Elias Sjoerd G., Lacle Miangela M., Moons Leon M.G. 1 nov 2019, In: Gastroenterology. 157 , p. 1222-1232.e4

First evidence for a dose-response relationship in patients treated with 166Ho-radioembolization:a prospective study

Bastiaannet Remco, van Roekel Caren, Smits Maarten L J, Elias Sjoerd G, van Amsterdam Wouter A C, Doan Dan T, Prince Jip F, Bruijnen Rutger C G, de Jong Hugo W A M, Lam Marnix G E H 10 okt 2019, In: Journal of Nuclear Medicine. 61 , p. 608-612 5 p.

Choosing the right strategy based on individualized treatment effect predictions: Combination versus sequential chemotherapy in patients with metastatic colorectal cancer

Koopman M., Kwakman J. J., van Kruijsdijk R. C. M., Elias S. G., Seymour M. T., Meade A. M., Visseren F., Punt C. J. A. okt 2019, In: Annals of Oncology. 30

The Changing Role of Gene-Expression Profiling in the Era of De-escalating Adjuvant Chemotherapy in Early-Stage Breast Cancer

van Steenhoven J E C, Kuijer A, Schreuder K, Elias S G, van Diest P J, van der Wall E, Siesling S, van Dalen T okt 2019, In: Annals of Surgical Oncology. 26 , p. 3495-3501 7 p.

Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy

Ubink I., Bolhaqueiro A. C. F., Elias S. G., Raats D. A. E., Constantinides A., Peters N. A., Wassenaar E. C. E., de Hingh I. H. J. T., Rovers K. P., van Grevenstein W. M. U., Lacle M. M., Kops G. J. P. L., Rinkes I. H. M. Borel, Kranenburg O. sep 2019, In: British Journal of Surgery. 106 , p. 1404-1414 11 p.

Lesion detection by [89Zr]Zr-DFO-girentuximab and [18F]FDG-PET/CT in patients with newly diagnosed metastatic renal cell carcinoma

Verhoeff Sarah R, van Es Suzanne C, Boon Eline, van Helden Erik, Angus Lindsay, Elias Sjoerd G, Oosting Sjoukje F, Aarntzen Erik H, Brouwers Adrienne H, Kwee Thomas C, Heskamp Sandra, Hoekstra Otto S, Verheul Henk, van der Veldt Astrid A M, de Vries Elisabeth G E, Boerman Otto C, van der Graaf Winette T A, Oyen Wim J G, van Herpen Carla M L 1 aug 2019, In: European Journal of Nuclear Medicine and Molecular Imaging. 46 , p. 1931-1939 9 p.


Brand Eelco C., Elias Sjoerd G., Minderhoud Itta M., van der Veen Julius J., Baert Filip J., Laharie David, Bossuyt Peter, Bouhnik Yoram, Buisson Anthony, Lambrecht Guy, Louis Edouard, Pariente Benjamin, Pierik Marie, Van Der Woude Christien Janneke, D'Haens Geert R., Vermeire Severine, Oldenburg Bas mei 2019, In: Gastroenterology. 156 , p. S848-S848

Prediction of endoscopic activity in patients with Crohn's disease: systematic review and external validation of published prediction models

Brand E. C., Elias S. G., Minderhoud I. M., van der Veen J. J., Baert F., Laharie D., Bossuyt P., Bouhnik Y., Buisson A., Lambrecht G., Louis E., Pariente B., Pierik M. J., van der Woude C. J., D'Haens G. R., Vermeire S., Oldenburg B. mrt 2019, In: Journal of Crohn's & Colitis. 13 , p. S338-S339

Regional Recurrence Risk Following a Negative Sentinel Node Procedure Does Not Approximate the False-Negative Rate of the Sentinel Node Procedure in Breast Cancer Patients Not Receiving Radiotherapy or Systemic Treatment

Roos Marleen M., van Steenhoven Julia E.C., Aalders Kim C., Schreuder Kay, Burgmans Josephina P.J., Siesling Sabine, Elias Sjoerd, van Dalen Thijs 15 feb 2019, In: Annals of Surgical Oncology. 26 , p. 372-378 7 p.

All Research Output (144)