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prof. dr. N.M. (Nico M.) Wulffraat

Full Professor

  • Cluster B
  • Rheumatology Research 1
  • Immunology

prof. dr. N.M. (Nico M.) Wulffraat

Biography

Nico Wulffraat is professor of pediatric Rheumatology at the department of pediatrics, University Medical Center, Utrecht, The Netherlands. He obtained his MD and PhD (1987) at the Free University Hospital Amsterdam. He trained as a paediatrician from 1988 untill 1993 in Utrecht. He was fellow pediatric immunology and rheumatology from 1993 to 1995 in the WKZ. Since 1995 he worked as a consultant in pediatric immunology-rheumatology. Since 2010 he is the head of this subunit. From 1997-2004 he was also coordinator of the pediatric allogeneic and autologous stem cell transplantations for immune deficiencies, metabolic disorders and autoimmune diseases. He is PI of several investigator initiated trials of immunisations in children with rheumatic diseases including MMR, HPV and Men C, prevention of MTX side effects, and application of Mesenchymal Stem cells in refractory GvHD and JIA. He is coordinator of a FP7 consortium for pharmacovigilance of biologics used in JIA (PHARMACHILD). Also he leads the EHHC project SHARE that aims at documenting standards of care and treatment recommendations for pediatric rheumatic diseases throughout Europe.

Since 2008 he became supervisor of the postgraduate clinical fellowship pediatric rheumatology and since 2009 head of pediatric immunology and rheumatology. In 2014, he was appointed as head of pediatric Rheumatology, Immunology, hematology and infectious diseases.

He has co-authored 220 Pubmed cited papers in international journals on pediatric rheumatology and immunology and 12 chapters in books.

Side Activities

  • Coördinator ERN/RITA 2019 - heden

    Commissie lid ZONMW Translationeel Adult Stamcelresearch

    Commissielid ZONMW call Priority Medicins Children, thans Goed gebruik Geneesmiddelen

    Editor Werkboek Kinderreumatologie

    Werkgroep uveitis richtlijn (Orde medisch specialisten, 2014-2015)

    Lid Drug safety Monitoring Board Sycamore trial (RCT for adalimumab   in JIA associated uveitis).

    Lid bestuur Pediatric Rheumatology European Society (PRES, treasurer, 2012-)

    Lid bestuur Pediatric Rheumatology International Trials organization (Printo, 2012-)

    Editorial board Pediatric Rheumatology Online Journal

    Reviewer for all major rheumatology Journals, Blood, Lancet, NEJM

    Organiser (PRES representative) and faculty of basic& advanced educational courses in pediatric Rheumatology (India, Turkey, Brasilia)

Fellowship and Awards

  • FP7 Grant Pharmachild

    AEMC Grant SHARE

    Div. ZON MW Grants

    UCAN CANDU

    Foreum

    AbbVie (bijdrage Reuma2Go)

    Roche (bijdrage Reuma2Go)

    ERN coordinator RITA

    ZonMW grant Chronic Fatique QFS and JIA

Research Output (503)

Fatigue in childhood chronic disease

Nap-Van Der Vlist Merel M., Dalmeijer Geertje W., Grootenhuis Martha A., Van Der Ent Cornelis K., Van Den Heuvel-Eibrink Marry M., Wulffraat Nico M., Swart Joost F., Van Litsenburg Raphaële R.L., Van De Putte Elise M., Nijhof Sanne L. 7 jun 2019, In: Archives of Disease in Childhood. 104 , p. 1090-1095 6 p.

Barbara Ansell:A person ahead of her time

Woo Pat, Wulffraat Nico M., Tyndall Alan 1 jun 2019, In: Annals of the Rheumatic Diseases. 78 , p. 725-728 4 p.

AN INTERNATIONAL SURVEY ON APPROACHES TOWARDS IMMUNISATION IN CHILDREN WITH RHEUMATIC DISEASES: A REPORT OF THE PRES VACCINATIONS WORKING GROUP

Moraitis Elena, Maritsi D., Uziel Yosef, Pileggi Gecilmara Salviato, Khubchandani Raju, Jansen Marc, Wulffraat Nico, Toplak Natasa jun 2019, In: Annals of the Rheumatic Diseases. 78 , p. 1343-1343

INFECTIOUS RISK AND MANAGEMENT OF VACCINATION

Wulffraat Nico jun 2019, In: Annals of the Rheumatic Diseases. 78 , p. 3-3

LIVE ATTENUATED VACCINES IN PEDIATRIC RHEUMATIC DISEASES ARE SAFE: MULTICENTER, RETROSPECTIVE DATA COLLECTION

Uziel Yosef, Bergonzo Veronica Moshe, Onozo Beata, Kulcsar Andrea, Trobert-Sipos Diana, Akikusa Jonathan, Pileggi Gecilmara Salviato, Maritsi Despoina, Kasapcopur Ozgur, Smerla Roubini, Rigante Donato, Atasali Erato, Rodrigues Mariana, Makay Balahan, Wulffraat Nico, Toplak Natasa jun 2019, In: Annals of the Rheumatic Diseases. 78 , p. 178-179

TOWARDS EUROPEAN HARMONISATION OF HEALT CARE FOR PATIENTS WITH RARE IMMUNE DISORDERS: ERN RITA RESULT FROM THE REGISTRIES SURVEY

Papa Riccardo, Cant Andrew, Klein Christoph, Little Mark, Wulffraat Nico M., Gattorno Marco, Ruperto Nicolino jun 2019, In: Annals of the Rheumatic Diseases. 78 , p. 1381-1383

EFFICACY OF CANAKINUMAB, ON A REDUCED DOSE OR A PROLONGED DOSE INTERVAL WITHOUT CONCOMITANT CORTICOSTEROIDS AND METHOTREXATE, IN PATIENTS WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS

Quartier Pierre, Alexeeva Ekaterina, Wouters Carine, Calvo Inmaculada, Kallinich Tilmann, Wulffraat Nico, Wei Xiaoling, Slade Alan, Abrams Ken, Martini Alberto jun 2019, In: Annals of the Rheumatic Diseases. 78 , p. 98-99

HOME MONITORING OF INACTIVE DISEASE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS: PREDICTIVE VALUE OF EQ-5D-5L-Y

Doeleman Martijn J. H., De Roock Sytze, Buijsse Nathan, Klein Mark, Bonsel Gouke J., Seyfert V., Wulffraat Nico, Swart Joost F. jun 2019, In: Annals of the Rheumatic Diseases. 78 , p. 1336-1336

DEVELOPMENT OF A PREDICTIVE TOOL FOR RESPONSE TO ANTI-TNF-ALPHA THERAPY IN JIA USING GENE EXPRESSION PROFILES IN PERIPHERAL DERIVED MONONUCLEAR CELLS

Baaij Jedidja, Scholman Rianne, Yeung Rae, Duong Trang, Wulffraat Nico, Swart Joost F., Vastert Sebastian, De Roock Sytze jun 2019, In: Annals of the Rheumatic Diseases. 78 , p. 554-554

SERIOUS/AT LEAST MODERATE INFECTIONS IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS ON SYNTHETIC AND BIOLOGIC DRUGS FROM THE PHARMACHILD REGISTRY

Giancane Gabriella, Swart Joost F., Tzaribachev Nikolay, Rubio Nadina, Cuttica Ruben, Rumba-Rozenfelde Ingrida, Suwairi Wafaa Mohammed Saad, Lazar Calin, Uziel Yosef, Telcharova Albena, Avcin Tadej, Minaici Angela, Len Claudio, Garay Stella Maris, Boteanu Alina, Pistorio Angela, Wulffraat Nico, Ruperto Nicolino jun 2019, In: Annals of the Rheumatic Diseases. 78 , p. 629-629

All Research Output (503)