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Publications

  • Respiratory syncytial virus prophylaxis in Down syndrome: a prospective cohort study. Yi H, Lanctôt KL, Bont L, Bloemers BL, Weijerman M, Broers C, Li A, Kiss A, Mitchell I, Paes B; CARESS investigators. Pediatrics. 2014 Jun;133(6):1031-7. doi: 10.1542/peds.2013-3916. Epub 2014 May 5. PMID: 24799541

 

  • Elevated Th17 response in infants undergoing respiratory viral infection. Stoppelenburg AJ, de Roock S, Hennus MP, Bont L, Boes M. Am J Pathol. 2014 May;184(5):1274-9. doi: 10.1016/j.ajpath.2014.01.033. Epub 2014 Mar 17.PMID: 24650560

 

  • Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis. Randolph AG, Yip WK, Falkenstein-Hagander K, Weiss ST, Janssen R, Keisling S, Bont L. Clin Exp Allergy. 2014 Feb;44(2):231-7. doi: 10.1111/cea.12247. PMID: 24447085

 

  • Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. Blanken MO, Rovers MM, Molenaar JM, Winkler-Seinstra PL, Meijer A, Kimpen JL, Bont L; Dutch RSV Neonatal Network.N Engl J Med. 2013 May 9;368(19):1791-9. doi: 10.1056/NEJMoa1211917. PMID: 23656644

 

  • Host response to mechanical ventilation for viral respiratory tract infection. Hennus MP, Janssen R, Pennings JL, Hodemaekers HM, Kruijsen D, Jansen NJ, Meyaard L, van Vught AJ, Bont LJ. Eur Respir J. 2012 Dec;40(6):1508-15. doi: 10.1183/09031936.00177111. Epub 2012 Apr 10. PMID: 22496321

 

  • Proteins involved in extracellular matrix dynamics are associated with respiratory syncytial virus disease severity. Schuurhof A, Bont L, Hodemaekers HM, de Klerk A, de Groot H, Hofland RW, van de Pol AC, Kimpen JL, Janssen R.Eur Respir J. 2012 Jun;39(6):1475-81. doi: 10.1183/09031936.00012311. Epub 2012 Jan 20. PMID: 22267765

 

  • Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Belderbos ME, Houben ML, Wilbrink B, Lentjes E, Bloemen EM, Kimpen JL, Rovers M, Bont L. Pediatrics. 2011 Jun;127(6):e1513-20. doi: 10.1542/peds.2010-3054. Epub 2011 May 9. PMID: 21555499

 

  • Clinical prediction rule for RSV bronchiolitis in healthy newborns: prognostic birth cohort study. Houben ML, Bont L, Wilbrink B, Belderbos ME, Kimpen JL, Visser GH, Rovers MM. Pediatrics. 2011 Jan;127(1):35-41. doi: 10.1542/peds.2010-0581. Epub 2010 Dec 27. PMID: 21187309

 

  • Nosocomial RSV infection control and outbreak management. Bont L. Pediatric Respir Rev. 2009 Jun;10 Suppl 1:16-7. doi: 10.1016/S1526-0542(09)70008-9. Review. PMID: 19651394

 

  • The effect of high dose inhaled corticosteroids on wheeze in infants after respiratory syncytial virus infection: randomized double blind placebo controlled trial. Ermers MJ, Rovers MM, van Woensel JB, Kimpen JL, Bont LJ; RSV Corticosteroid Study Group.BMJ. 2009 Mar 31;338:b897. doi: 10.1136/bmj.b897.PMID: 19336497

 

  • Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B. J Infect Dis. 2007 Sep 15;196(6):826-34. Epub 2007 Aug 10.PMID: 17703412 [PubMed - indexed for MEDLINE] Free Article

 

  • IL-13 genetic polymorphism identifies children with late wheezing after respiratory syncytial virus infection. Ermers MJ, Hoebee B, Hodemaekers HM, Kimman TG, Kimpen JL, Bont L., J Allergy Clin Immunol. 2007 May;119(5):1086-91. Epub 2007 Feb 20.PMID: 17313976

 

  • Impact of wheezing after respiratory syncytial virus infection on health-related quality of life. Bont L, Steijn M, van Aalderen WM, Kimpen JL. Pediatric Infect Dis J. 2004 May;23(5):414-7.PMID: 15131463

 

  • Natural reinfection with respiratory syncytial virus does not boost virus-specific T-cell immunity. Bont L, Versteegh J, Swelsen WT, Heijnen CJ, Kavelaars A, Brus F, Draaisma JM, Pekelharing-Berghuis M, van Diemen-Steenvoorde RA, Kimpen JL. Pediatr Res. 2002 Sep;52(3):363-7.PMID: 12193668

 

  • Blanken MO, Rovers MM, Molenaar JM, Winkler-Seinstra PL, Meijer A, Kimpen JL, Bont L, Dutch RVS Neonatal Network. Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N Engl J Med 2013, 368(19): 1791-9. Dio: 10.1056/NEJMoa1211917.
    This placebo controlled trial provides conclusive evidence that RSV is causally related to recurrent wheeze.

 

  • Hennus MP, Janssen R, Pennings JL, Hodemaekers HM, Kruijsen D, Jansen NJ, Meyaard L, van Vught AJ, Bont JL. Host response to mechanical ventilation for viral respiratory tract infection. Eur Respir J 2012, 40(6): 1508-15. Doi: 10.1183/09031936.00177111.

    This mouse study shows distinct molecular signature of RSV infection and subsequent inflammation induced by mechanical ventilation.

 

  • Belderbos ME, Houben ML, Wilbrink B, Lentjes E, Bloemen EM, Kimpen JL, Rovers M, Bont LJ. Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics 2011, 127(6):e1513-20. Doi:10.1542/peds.2010-3054.

    This publication is one from many of the Netherlands Amniotic Fluid (NAF) healthy birth cohort study. This publication showed that vitamin D deficiency at birth is related to increased risk of RSV bronchiolitis.