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prof. dr. I.H.M. Borel Rinkes Full Professor

  • Department of Surgical Oncology

I.H.M. Borel Rinkes

Contact

Research Programs

Biography

Inne Borel Rinkes attended medical School (Leiden University) from 1976-1984 (MD-degree cum laude) while working as donor-allocation-coordinator for Eurotransplant. From 1984-1986 he was resident in surgery Red Cross Hospital,The Hague (supervisor dr. J. Hamming). He had his formal surgical training from 1986-1993 in Rotterdam (Zuiderziekenhuis, dr. G. Olthuis; University Hospital Dijkzigt, Prof. J. Jeekel). His training was interrupted for 1.5 years for doctoral research at Massachusetts General Hospital/Harvard University, Center for Engineering in Medicine (Profs. Toner, Yarmush and Tompkins). Inne Borel Rinkes obtained his PhD degree in 1993 on the dissertation “Hepatocytes in the development of liver support systems”.
In 1993 he became surgeon in the Dr. Daniel den Hoed Cancer Center in Rotterdam. In 1995 he became staff surgeon in the University Medical Center in Utrecht, where he was appointed full professor of Surgical Oncology in 2002. Between 2001 and 2012 he was director of the residency program in surgery and chairman of the Concilium Chirurgicum. From 2006 to 2012 he was member of the scientific council of the Dutch Cancer Society (KWF) and chairman of the translational research-committee. In 2012 he received the Catharijne Prize for outstanding translational research and clinical work. His main topics of interest include HPB-surgery and Endocrine surgery. His research focus involves (targeting) the development of liver metastases.

Side Activities

  • Bestuurslid Stichting Sacha Swarttouw (Research Grants Dikkedarmkanker)

     

    Bestuurslid Stichting Michael van Vloten Fonds (Onderzoeksbeurzen chirurgisch onderzoek buitenland)

     

    Voorzitter Regenten Hippocrates Studiefonds (Onderzoeksprijzen med studenten)

     

    Bestuurslid Netherlands Society for International Surgery

Fellowship and Awards

  • 2013 Catharijne Award for outstanding translational research & surgical  oncology patient care
    Effects of anti-angiogenic therapy on physiological and pathological angiogenesis; Dutch Society for Scientific Research (NWO)-920-03-102; AGIKO E.A. te Velde
    Angiogenesis and the liver: role of angiogenesis in liver regeneration and cirrhosis; Private fund and Vanderes foundation; J.M. Vogten
    Anti-angiogenic effects of photodynamic therapy in experimental cancer; Dutch Cancer Foundation 
    Implenting stereotactic large-core needle biopsy for non-palpable breast cancer lesions; Dutch Society for Scientific Research (NWO -920-03-159 and Stichting Centraal Fonds Vrijwillige Reserves; AGIKO L.E. Hoorntje
    Early effects of liver metastases on hepatic microcirculation; Vanderes foundation – 2001/63
    Is angiogenesis the key to more effective local thermal ablation of colorectal liver metastases?; Dutch Society for Scientific Research (NWO)-920-03-159; AGIKO L.M. Veenendaal 
    Surgery-induced hypoxia, angiogenesis, and tumor growth; Private Fund.
    Reovirus oncolysis of colorectal liver metastases (2004); Dutch Society for Scientific Research (NWO)-920-03-313; AGIKO: J.D.W. van der Bilt
    Long term effects of short term ischemia on metastatic colorectal cancer cells; Dutch Cancer Foundation 2006-3711 (1year research grant for clinical assistants to M. Nijkamp) 
    Anti-tumor therapy with an adeno-associated virus (AAV) suppressing the K-Ras oncogene by RNA interference; Dutch Society for Scientific Research (NWO)-920-03-382; AGIKO W. van Houdt
    Apoptosis control in metastases of colorectal cancer (2006); Private fund
    Identification of metastasis genes activated by oncogenic Kras (G12D); Association for International Cancer Research (AICR) 2007-552
    Identification of metastasis stimulating genes activated by oncogenic Kras; Vanderes foundation 2007-177
    A gene expression signature for prediction of disease free survival after Ro resection of colorectal liver metastasis; Dutch Cancer Foundation (KWF) 2007-3923
    Radioguided occult lesion localisation in patients with non-palpable breast cancer (ROLL); Dutch Society for Scientific Research (ZonW) 17088.2101
    The Role of sprituality in the adjustment of patients with cancer; Dutch Cancer Foundation (KWF) HDI 2008-4076
    The secretome of colon cancer stem cells; Dutch Cancer Foundation (KWF) UU 2009-4367 (research grant for B.L. Emmink)
    Death receptor signaling in liver metastasis formation; Dutch Cancer Foundation (KWF) UU 2009-4379 (research grant for E.J.A. Steller)
    Preventing recurrence of colorectal liver metastases following liver surgery by hypoxia-activated pro-drugs (KWF) UU 2010-4608 (research grant for K. Govaert)
    Wijnand M. Pon Foundation Het volgen van kankerstamcel tot leveruitzaaiing
    Prevention of Breast Cancer by Monitoring Gene Promoter Methylation in Nipple Aspirates; Dutch Cancer Foundation (KWF) UU 2008-4217
    Killing hypoxic colorectal cancer stam cells; Dutch Cancer Foundation (KWF) UU 2013-5865 (research grant for J.M.J. Jongen)
    Targeting cancer stem cells in colon cancer. Stichting Vrienden UMC Utrecht 2013, 217.000 euro.
    Platelet-derived growth factor receptor inhibition in mesenchymal-type colorectal cancer. Dutch Cancer Foundation (KWF) UU 2014-6617 (research grant for I. Ubink).
    PDGF-receptor-targeted therapy for the treatment of poor prognosis mesenchymaltype colon cancer: a widow trial. ZonMw (95104001) 93.300 euro
    What is the best treatment for MEN1 patients with duodenopancreatic neuroendocrine tumors? Twenty-two years of survival to be gained.
    Dutch Cancer Foundation (KWF) UU 2014-7102 (research grant for S. Nell) 152.421,- euro. (2e PI)

Research Output (199)

Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures

van der Waals Lizet M, Laoukili Jamila, Jongen Jennifer M J, Raats Danielle A, Borel Rinkes Inne H M, Kranenburg Onno 1 dec 2019, In: Scientific Reports. 9

Is hepatectomy safe following Yttrium-90 therapy? A multi-institutional international experience

Melstrom Laleh G., Eng Oliver S., Raoof Mustafa, Singh Gagandeep, Fong Yuman, Latorre Karen, Choi Gi H., Salem Riad, Bentrem David J., Lewandowski Robert, Makris Eleftherios, Poultsides George, Dhar Vikrom K., Chadalavada Seetharam, Shah Shimul A., Johnson Aileen C., Sekhar Aarti, Kies Darren, Maithel Shishir K., Rocha Flavio, Alseidi Adnan, Hagendoorn Jeroen, Borel Rinkes Inne H.M., Fisher Alexander V., Ronnekleiv-Kelly Sean, Weber Sharon M., Winslow Emily R., Abbott Daniel E. 1 nov 2019, In: HPB. 21 , p. 1520-1526 7 p.

Prognostic factors and survival in MEN1 patients with gastrinomas:Results from the DutchMEN study group (DMSG)

van Beek Dirk-Jan, Nell Sjoerd, Pieterman Carolina R C, de Herder Wouter W, van de Ven Annenienke C, Dekkers Olaf M, van der Horst-Schrivers Anouk N, Drent Madeleine L, Bisschop Peter H, Havekes Bas, Borel Rinkes Inne H M, Vriens Menno R, Valk Gerlof D 1 nov 2019, In: Journal of Surgical Oncology. 120 , p. 966-975 10 p.

Robotic right hepatectomy for a central liver tumor- A video of the surgical technique -

Nota Carolijn L.M.A., Molenaar I. Quintus, Borel Rinkes Inne H.M., Hagendoorn Jeroen 1 sep 2019, In: Surgical Oncology. 30 , p. 108 1 p.

Recurrence after neoadjuvant therapy and resection of borderline resectable and locally advanced pancreatic cancer

Groot Vincent P., Blair Alex B., Gemenetzis Georgios, Ding Ding, Burkhart Richard A., Yu Jun, Borel Rinkes Inne H.M., Molenaar I. Quintus, Cameron John L., Weiss Matthew J., Wolfgang Christopher L., He Jin 1 sep 2019, In: European Journal of Surgical Oncology. 45 , p. 1674-1683 10 p.

Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES):a multicentre, parallel-group, randomised, open-label, superiority trial

Lambrichts Daniël P.V., Vennix Sandra, Musters Gijsbert D., Mulder Irene M., Swank Hilko A., Hoofwijk Anton G.M., Belgers Eric H.J., Stockmann Hein B.A.C., Eijsbouts Quirijn A.J., Gerhards Michael F., van Wagensveld Bart A., van Geloven Anna A.W., Crolla Rogier M.P.H., Nienhuijs Simon W., Govaert Marc J.P.M., di Saverio Salomone, D'Hoore André J.L., Consten Esther C.J., van Grevenstein Wilhelmina M.U., Pierik Robert E.G.J.M., Kruyt Philip M., van der Hoeven Joost A.B., Steup Willem H., Catena Fausto, Konsten Joop L.M., Vermeulen Jefrey, van Dieren S., Bemelman Willem A., Lange Johan F., Hop W. C., Opmeer B. C., Reitsma J. B., Meijer D. W., Matthijsen R., Blom R., Wijsman J. H., de Maat M. F.G., Boom M. J., de Vries M., Stam M. A.W., Verweij M. S., Steller E. P., de Graaf E. J.R., Vermaas M., Wiezer M. J., Smits A. B., Hendriks E. R., Borel Rinkes I. H.M., Molenaar I. Q., Nijs S. 1 aug 2019, In: The Lancet Gastroenterology and Hepatology. 4 , p. 599-610 12 p.

Predicting Successful Catheter Drainage in Patients with Pancreatic Fistula after Pancreatoduodenectomy

Smits F. Jasmijn, Van Santvoort Hjalmar C., Besselink Marc G., Boerma Djamila, Busch Olivier R., Van Dam Ronald M., Van Eijck Casper H., Festen Sebastiaan, Van Der Harst Erwin, De Hingh Ignace H., De Jong Koert P., Borel Rinkes Inne H., Molenaar I. Quintus 1 jul 2019, In: Pancreas. 48 , p. 811-816 6 p.

Defining and Predicting Early Recurrence in 957 Patients With Resected Pancreatic Ductal Adenocarcinoma

Groot Vincent P., Gemenetzis Georgios, Blair Alex B., Rivero-Soto Roberto J., Yu Jun, Javed Ammar A., Burkhart Richard A., Rinkes Inne H.M.Borel, Molenaar I. Quintus, Cameron John L., Weiss Matthew J., Wolfgang Christopher L., He Jin 1 jun 2019, In: Annals of Surgery. 269 , p. 1154-1162 9 p.

Robotgeassisteerde transaxillaire schildklieroperatie:5 jaar later

Vriens Menno R., Postma Emily L., Borel Rinkes Inne H.M. 1 jan 2019, In: Nederlands Tijdschrift voor Geneeskunde. 163

TOETVA:Schildklierchirurgie zonder blijvend litteken

Vriens Menno R., Borel Rinkes Inne H.M. 1 jan 2019, In: Nederlands Tijdschrift voor Geneeskunde. 163

All Research Output (199)
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