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dr. A.N. (Niels) Bovenschen Associate Professor

  • Department of Pathology

A.N. Bovenschen


Research Programs


Niels Bovenschen studied Medical Biology at the Free University in Amsterdam. After obtaining his PhD in 2003 at Sanquin Research at CLB Amsterdam, he worked as a postdoc in Leiden (TNO, Gaubius Laboratory). In 2004, he moved to the department of Pathology at the University Medical Center Utrecht (UMC Utrecht). In 2006, he received a prestigious VENI grant from the Netherlands Organization for Scientific Research (NWO) for his work on serine proteases (i.e. granzymes) in the cytolytic granules of cytotoxic lymphocytes. In 2009 he became group leader (Assistant Professor) at the department of Pathology (UMC Utrecht). In 2012, he was appointed as Associate Professor at the same department. His research group now focuses on the effector immune response in eliminating tumor cells and virus-infected cells. These aims fit within the UMC Utrecht focus areas Immunity & Infection and Cancer. He is in charge of the UMC Utrecht Pathology Research Laboratory and head of the Laboratory of Translational Immunology core facility Proteins. In 2017, Niels Bovenschen was appointed as Senior Fellow of Utrecht University. His mission is to engage undergraduate students in science by creating synergy between education and scientific research already at the early undergraduate level. He is examiner and coordinator of several (bio)medical educational programs at the faculty of Medicine, Utrecht University. In 2019, Niels Bovenschen won the Outstanding Teacher Award of Utrecht University.

Side Activities

  • Member KNAW Comenius network

    Academic Editor: PLoS ONE

    Editorial Board Member: Front. Cell. Dev. Biol.

Fellowship and Awards

  • 2019: Outstanding Teacher Award. Docent van het jaar. Utrecht University

    2018: NWO Comenius Teaching Fellow grant

    2018: Lecturer of the year. Docent van het jaar. Faculty of Medicine, Utrecht University

    2017: Teaching Fellow Utrecht University

    2015: Project grant Pediatric Brain Cancer Foundation Koppie-AU.

    2013: Project grant Pediatric Brain Cancer Foundation Koppie-AU.

    2012: Infection & Immunity Center Utrecht seeding project grant.

    2009: Dutch Cancer Society (KWF) project grant.

    2008: UMCU/DLA Research project grant.

    2006: NWO/ZonMw VENI grant (Netherlands Organization for Scientific Research).

Research Output (65)

How a four-year-old boy connects healthcare, biomedical research and undergraduate education

Drost Rijkent H., Dictus Wim J.A.G., Prakken Berent J., Bovenschen Niels 1 sep 2019, In: Nature Biotechnology. 37 , p. 1092-1095 4 p.

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

Bengsch Bertram, Ohtani Takuya, Khan Omar, Setty Manu, Manne Sasikanth, O'Brien Shaun, Gherardini Pier Federico, Herati Ramin Sedaghat, Huang Alexander C., Chang Kyong Mi, Newell Evan W., Bovenschen Niels, Pe'er Dana, Albelda Steven M., Wherry E. John 15 mei 2018, In: Immunity. 48 , p. 1029-1045.e5

Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns

Bengsch Bertram, Ohtani Takuya, Herati Ramin Sedaghat, Bovenschen Niels, Chang Kyong Mi, Wherry E. John feb 2018, In: Journal of Immunological Methods. 453 , p. 3-10 8 p.

Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma

Vermeulen Jeroen F., Van Hecke Wim, Adriaansen Elisabeth J M, Jansen Mieke K., Bouma Rianne G., Villacorta Hidalgo José, Fisch Paul, Broekhuizen Roel, Spliet Wim G.M., Kool Marcel, Bovenschen Niels 2018, In: OncoImmunology. 7 , p. e1398877

Oncogenic role of cytomegalovirus in medulloblastoma?

Hortal Alejandro M., Vermeulen Jeroen F., Van Hecke Wim, Bovenschen Niels 1 nov 2017, In: Cancer Letters. 408 , p. 55-59 5 p.

Proteomic profiling of the spinal cord in ALS:decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis

Engelen-Lee Jooyeon, Blokhuis Anna M., Spliet Wim G.M., Pasterkamp R. Jeroen, Aronica Eleonora, Demmers Jeroen A A, Broekhuizen Roel, Nardo Giovanni, Bovenschen Niels, Van Den Berg Leonard H. 3 apr 2017, In: Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 18 , p. 210-220 11 p.

A novel proinflammatory role for granzyme A

Van Eck Jacqueline A., Shan Liling, Meeldijk Jan, Hack C. Erik, Bovenschen Niels 23 feb 2017, In: Cell death & disease. 8

Granzymes A and K differentially potentiate LPS-induced cytokine response

Wensink Annette C., Kok Helena M., Meeldijk Jan, Fermie Job, Froelich Christopher J., Hack C. Erik, Bovenschen Niels 2 dec 2016, In: Cell death discovery. 2

Biological responses of human solid tumor cells to X-ray irradiation within a 1.5-Tesla magnetic field generated by a magnetic resonance imaging–linear accelerator

Wang Li, Hoogcarspel Stan Jelle, Wen Zhifei, van Vulpen Marco, Molkentine David P., Kok Jan, Lin Steven H., Broekhuizen Roel, Ang Kie Kian, Bovenschen Niels, Raaymakers Bas W., Frank Steven J. 1 okt 2016, In: Bioelectromagnetics. 37 , p. 471-480 10 p.

No evidence for human cytomegalovirus infection in pediatric medulloblastomas

Vermeulen Jeroen F, van Hecke Wim, Jansen Mieke K, Spliet Wim G M, Broekhuizen Roel, Bovenschen Niels 12 aug 2016, In: Neuro-Oncology. 18 , p. 1461-1462

All Research Output (65)
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