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dr. R.M. (Rachel) Brouwer Assistant Professor

  • Psychiatry


Research Programs


Rachel Brouwer obtained her PhD in the field of mathematics under supervision of Prof. J. van den Berg, at the Center of Mathematics and Computer Science in 2005. The title of her PhD was “Percolation, forest-fires and monomer-dimers, or the hunt for self-organized criticality”.

Since april 2006, she is working in the Department of Psychiatry of the University Medical Center Utrecht, were she is senior researcher on the BrainSCALE project, a longitudinal twin study into healthy development of brain and cognition during puberty, and the genetic and environmental components that influence this development. She is involved in the twin studies of the department, and in development of post-processing of MRI data and its statistical analysis.

Research lines

BrainSCALE project; a longitudinal twin-sibling study in adolescence into brain and cognition

ENIGMA-plasticity; through the ENIGMA consortium we investigate the genetics of brain plasticity measured through longitudinal MRI

Selected publications

Rachel M Brouwer, Matthew S Panizzon, David C Glahn, Derrek P Hibar, Xue Hua, Neda Jahanshad, Lucija Abramovic, Greig I de Zubicaray, Carol E Franz, Narelle K Hansell, Ian B Hickie, Marinka M G Koenis, Nicholas G Martin, Karen A Mather, Katie L McMahon, Hugo G Schnack, Lachlan T Strike, Suzanne C Swagerman, Anbupalam Thalamuthu, Wei Wen & 9 others, 2017, Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Human brain mapping DOI.

Bohlken, M. M., Brouwer, R. M., Mandl, R. C. W., Kahn, R. S. & Hulshoff Pol, H. E. (2016) Genetic Variation in Schizophrenia Liability is Shared With Intellectual Ability and Brain Structure. Schizophrenia Bulletin. 425p. 1167-1175

Brouwer, R. M., Hedman, A. M., van Haren, N. E. M., Schnack, H. G., Brans, R. G. H., Smit, D. J., Kahn, R. S., Boomsma, D. I. & Hulshoff Pol, H. E. (2014) Heritability of brain volume change and its relation to intelligence. Neuroimage. 100p. 676-683 8 p.

van Soelen IL, Brouwer RM, van Baal GC, Schnack HG, Peper JS, Chen L, Kahn RS, Boomsma DI, Pol HE (2013): Heritability of volumetric brain changes and height in children entering puberty. Hum Brain Map Mar;34(3):713-25.


Research Output (87)

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal Claudia L., Adams Hieab H.H., Hibar Derrek P., White Charles C., Knol Maria J., Stein Jason L., Scholz Markus, Sargurupremraj Muralidharan, Jahanshad Neda, Roshchupkin Gennady V., Smith Albert V., Bis Joshua C., Jian Xueqiu, Luciano Michelle, Hofer Edith, Teumer Alexander, van der Lee Sven J., Yang Jingyun, Yanek Lisa R., Lee Tom V., Li Shuo, Hu Yanhui, Koh Jia Yu, Eicher John D., Desrivières Sylvane, Arias-Vasquez Alejandro, Chauhan Ganesh, Athanasiu Lavinia, Rentería Miguel E., Kim Sungeun, Hoehn David, Armstrong Nicola J., Chen Qiang, Holmes Avram J., den Braber Anouk, Kloszewska Iwona, Andersson Micael, Abramovic Lucija, Bohlken Marc M., Klein Marieke, Boks Marco P., van Eijk Kristel R., Cahn Wiepke, Hulshoff Pol Hilleke E., Ikram M. Kamran, Brouwer Rachel M., Kahn René S., Ophoff Roel A., van Haren Neeltje E.M., Schmidt Reinhold, 1 nov 2019, In: Nature Genetics. 51 , p. 1624-1636 13 p.

Genetic and environmental influences on functional connectivity within and between canonical cortical resting-state networks throughout adolescent development in boys and girls

Teeuw Jalmar, Brouwer Rachel M, Guimarães João P O F T, Brandner Philip, Koenis Marinka M G, Swagerman Suzanne C, Verwoert Maxime, Boomsma Dorret I, Hulshoff Pol Hilleke E 3 aug 2019, In: NeuroImage. 202 16 p.

Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa

Walton E., Hibar D., Yilmaz Z., Jahanshad N., Cheung J., Batury V. -L., Seitz J., Bulik C. M., Thompson P. M., Ehrlich Stefan, Hibar Derrek P., Stein Jason L., Renteria Miguel E., Arias-Vasquez Alejandro, Desrivieres Sylvane, Jahanshad Neda, Toro Roberto, Wittfeld Katharina, Abramovic Lucija, Andersson Micael, Aribisala Benjamin S., Armstrong Nicola J., Bernard Manon, Bohlken Marc M., Boks Marco P., Bralten Janita, Brown Andrew A., Chakravarty M. Mallar, Chen Qiang, Ching Christopher R. K., Cuellar-Partida Gabriel, Den Braber Anouk, Giddaluru Sudheer, Goldman Aaron L., Grimm Oliver, Guadalupe Tulio, Hass Johanna, Woldehawariat Girma, Klein Marieke, van Eijk Kristel R., Cahn Wiepke, Kahn Rene S., van Haren Neeltje E. M., Brouwer Rachel M., Pol Hilleke E. Hulshoff, Ophoff Roel, Adan Roger, Kas Martien, Koeleman Bobby, Ophoff Roel, 1 jul 2019, In: Molecular Neurobiology. 56 , p. 5146-5156 11 p.

The Association Between Familial Risk and Brain Abnormalities Is Disease Specific:An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

de Zwarte Sonja M C, Brouwer Rachel M, Agartz Ingrid, Alda Martin, Aleman André, Alpert Kathryn I, Bearden Carrie E, Bertolino Alessandro, Bois Catherine, Bonvino Aurora, Bramon Elvira, Buimer Elizabeth E L, Cahn Wiepke, Cannon Dara M, Cannon Tyrone D, Caseras Xavier, Castro-Fornieles Josefina, Chen Qiang, Chung Yoonho, De la Serna Elena, Di Giorgio Annabella, Doucet Gaelle E, Eker Mehmet Cagdas, Erk Susanne, Fears Scott C, Foley Sonya F, Frangou Sophia, Frankland Andrew, Fullerton Janice M, Glahn David C, Goghari Vina M, Goldman Aaron L, Gonul Ali Saffet, Gruber Oliver, de Haan Lieuwe, Hajek Tomas, Hawkins Emma L, Heinz Andreas, Hillegers Manon H J, Hulshoff Pol Hilleke, Hultman Christina M, Ingvar Martin, Johansson Viktoria, Jönsson Erik G, Kane Fergus, Kempton Matthew J, Koenis Marinka M G, van Os Jim, Kahn René, van Haren Neeltje E M, 13 jun 2019, In: Biological Psychiatry. 86 , p. 545-556 12 p.

ENIGMA-Relatives: The Association Between Familial Risk for Schizophrenia or Bipolar Disorder and Brain Abnormalities

de Zwarte Sonja, Brouwer Rachel, Ching Christopher, Andreassen Ole, van Erp Theo, Turner Jessica, Thompson Paul, Kahn Rene, van Haren Neeltje 15 mei 2019, In: Biological Psychiatry. 85 , p. S8-S9


Lemvigh Cecilie, Brouwer Rachel, Pantelis Christos, Hilker Rikke, Robbins Trevor W., Sahakian Barbara, Glenthoj Birte, Fagerlund Birgitte apr 2019, In: Schizophrenia Bulletin. 45 , p. S171-S171


Legind Christian, Broberg Brian, Brouwer Rachel, Mandl Rene, Ebdrup Bjorn H., Anhoj Simon, Jensen Maria H., Hilker Rikke Prime, Fagerlund Birgitte, Pol Hilleke Hulshoff, Glenthoj Birte, Rostrup Egill apr 2019, In: Schizophrenia Bulletin. 45 , p. S311-S311

Heritability of Cerebral Blood Flow and the Correlation to Schizophrenia Spectrum Disorders:A Pseudo-continuous Arterial Spin Labeling Twin Study

Legind Christian S, Broberg Brian V, Brouwer Rachel, Mandl René C W, Ebdrup Bjørn H, Anhøj Simon J, Jensen Maria H, Hilker Rikke, Fagerlund Birgitte, Hulshoff Pol Hilleke E, Glenthøj Birte Y, Rostrup Egill 18 feb 2019, In: Schizophrenia Bulletin. 45 , p. 1231-1241 11 p.

Genetic and environmental influences on circulating NK and T cells and their relation to bipolar disorder

Snijders G, Brouwer R, Kemner S, Bootsman F, Drexhage H A, Hillegers M H J 10 feb 2019, In: International journal of bipolar disorders. 7

Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data

Kochunov Peter, Patel Binish, Ganjgahi Habib, Donohue Brian, Ryan Meghann, Hong Elliot L., Chen Xu, Adhikari Bhim, Jahanshad Neda, Thompson Paul M., Van’t Ent Dennis, den Braber Anouk, de Geus Eco J.C., Brouwer Rachel M., Boomsma Dorret I., Hulshoff Pol Hilleke E., de Zubicaray Greig I., McMahon Katie L., Martin Nicholas G., Wright Margaret J., Nichols Thomas E. 7 feb 2019, In: Frontiers in Neuroinformatics [E]. 13

All Research Output (87)
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