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dr. R. (Roel) de Heus Assistant Professor - medical

  • Birth Center Obstetrics - Medical

R. de Heus


Research Programs


During his gynaecology training Roel de Heus finished his PhD “Maternal and Fetal effects of Tocolytic drugs” at the University of Utrecht in 2008 and worked for 6 months at the Mt Sinai Hospital in Toronto at the department of Maternal and Fetal medicine in 2012.

His clinical work as a gynaecologist at the Obstetrical department has its focus on fetal medicine / prenatal diagnosis, combining state of the art imaging techniques such as 2D/3D ultrasound and fetal MRI with genetic testing.

His aim is to improve patient care and more specific in the field of prenatal diagnosis and early developmental medicine. Focus within the research theme Brain on normal and abnormal early brain development. To study maternal and environmental influences on normal fetal brain development during pregnancy and its impact on child development as a part of the YOUth cohort (prof.dr. C. Kemner). Intra-uterine development, an important landmark for future health. Furthermore, to study and unravel mechanisms of abnormal fetal and neonatal brain development due to underlying congenital malformations, placental insufficiency or preterm birth to improve diagnosis, identify prognostic biomarkers and possible windows for neuroprotection to prevent perinatal brain damage.

Research Output (28)

Functional connectome of the fetal brai

Turk Elise, van den Heuvel Marion I., Benders Manon J., de Heus Roel, Franx Arie, Manning Janessa H., Hect Jasmine L., Hernandez-Andrade Edgar, Hassan Sonia S., Romero Roberto, Kahn René S., Thomason Moriah E., van den Heuvel Martijn P. 4 nov 2019, In: Journal of Neuroscience. 39 , p. 9716-9724 9 p.

First trimester placental vascularization and angiogenetic factors are associated with adverse pregnancy outcome

Leijnse Johanna E.W., de Heus Roel, de Jager Wilco, Rodenburg Wendy, Peeters Louis L.H., Franx Arie, Eijkelkamp Niels 1 jul 2018, In: Pregnancy Hypertension. 13 , p. 87-94 8 p.

Insights on emerging functional networks in the prenatal connectome

Turk E, benders m, de Heus R, Franx A 18 jun 2018,

Growth patterns in fetuses with isolated cardiac defects

Haveman Ilse, Fleurke-Rozema Johanna H., Mulder Eduard J.H., Benders Manon, du Marchie Sarvaas Gideon, ter Heide Henriette, de Heus Roel H., Bilardo Caterina M. 1 apr 2018, In: Prenatal Diagnosis. 38 , p. 328-336 9 p.

Increased Risk of Pregnancy Complications After Stroke:The FUTURE Study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation)

Van Alebeek Mayte E., De Vrijer Myrthe, Arntz Renate M., Maaijwee Noortje A.M.M., Synhaeve Nathalie E., Schoonderwaldt Hennie, Van Der Vlugt Maureen J., Van Dijk Ewoud J., De Heus Roel, Rutten-Jacobs Loes C.A., De Leeuw Frank Erik apr 2018, In: Stroke. 49 , p. 877-883 7 p.

Pregnancy and ischemic stroke:A practical guide to management

Van Alebeek Mayte E., De Heus Roel, Tuladhar Anil M., De Leeuw Frank Erik 1 feb 2018, In: Current Opinion in Neurology. 31 , p. 44-51 8 p.

Polyhydramnios in isolated oral cleft pregnancies:incidence and outcome in a retrospective study

Depla Anne L, Breugem Corstiaan C, van der Horst Chantal M A M, de Heus Roel, van den Boogaard Marie-José H, Maas Saskia M, Pajkrt Eva, Bekker Mireille N feb 2017, In: Prenatal Diagnosis. 37 , p. 162-167 6 p.

First-trimester Placental Vascular Development in Multiparous Women differs from that in Nulliparous Women

Ballering Gea, Leijnse Janneke, Eijkelkamp Niels, Peeters Louis, de Heus Roel 12 jan 2017, In: Journal of Maternal-fetal & Neonatal Medicine. 31 , p. 209-215 7 p.

Poor Placental Vascularization at 12 Weeks of Pregnancy Is Associated With a Specific Cluster of Serum Proteins

Leijnse Janneke, de Heus Roel, Peeters Louis L. H., Oudijk Martijn A., Franx Arie, Eijkelkamp Niels mrt 2015, In: Reproductive Sciences. 22 , p. 69A 1 p.

In Reply

Van Mieghem Tim, Klaritsch Philipp, Raio Luigi, Ranzini Angela C., Baud David, Barrett Jon, De Heus Roel, Ryan Greg 1 jan 2015, In: Obstetrics and Gynecology. 125 , p. 228-229 2 p.

All Research Output (28)
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