Back

prof. dr. L.S. (Linda) de Vries

Full Professor

  • Birth Center Neonatology - Medical

prof. dr. L.S. (Linda) de Vries

Biography

Linda de Vries obtained her PhD degree in Utrecht (1987) with Leo van de Brande. The degree was based on data collected during a 4 year research period at the Hammersmith Postgraduate school in London where she worked with Lilly and Victor Dubowitz in the field of Neonatal Neurology. Between 1987 and 1989 she did her Pediatric Neurology fellowship in Leuven with Paul Casaer. Since 1989, she has worked in the department of Neonatology in Utrecht, where she is a professor in Neonatal Neurology since 2001.

Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods.  These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity.  Her work has been published in >300 publications.

 

Research line

Neonatal Neurology

Most recent key publications

1: van de Aa NE, Benders MJNL, Vincken KL,Groenendaal F, de Vries LS, The course of apparent diffusion coefficient values following perinatal arterial ischemic stroke. PlosOne 2013;8(2):e56784
2: Haastert IC, Groenendaal F, Uiterwaal CSPM, Termote JUM, van der Heide-Jalving M, Eijsermans MJC, Gorter JW, Helders PJM, Jongmans MJ, de Vries LS. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011; 159:8
3: Van Rooij, LGM, Toet, MC , van Huffelen AC, Groenendaal F, Laan W, Zezic A, de Haan T, van Straaten ILM, Vrancken S, van Wezel G, van der Sluijs J, ter Horst H, Gavilanes D, Laroche S, Naulaers G, de Vries LS. Effect of treatment of subclinical neonatal seizures detected with continuous amplitude-integrated electroencephalographic monitoring: a randomised controlled Trial. Pediatrics. 2010;125:e358-66
4: de Vries LS, Koopman C, Groenendaal F, van Schooneveld M, Verheijen F, Verbeek E, WitkampTh D, van der Worp HB, Mancini GMS. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Annals Neurol 2009; 65:12-18
5: Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S, for the NEonatal seizure treatment with Medication Off -patent (NEMO)consortium Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurology 2015 Mar 9. pii: S1474-4422(14)70303-5

Fellowship and Awards

  • 1: Honorary award of the German speaking society of Neuropediatrics (GNP) 2015
    2: ZonMW, co-applicant, Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain (2011)
    3: EU-FP7, co-applicant, NEMO1: An open label exploratory dose finding and pharmacokinetic clinical trial of bumetanide for the treatment of NEonatal seizure using Medication Off-patent. (2010)
    4: Harwood Nash memorial lecture, Toronto, 2012
    5: McCance Lecture (British Neonatal Society), 2004
    6: Bruce Berg Visiting Professor Lecture (UCSF San Francisco), 2004

Research Output (609)

Non-right-handedness in children born extremely preterm:Relation to early neuroimaging and long-term neurodevelopment

van Heerwaarde Alise A, van der Kamp Laura T, van der Aa Niek E, de Vries Linda S, Groenendaal Floris, Jongmans Marian J, Eijsermans Rian J C, Koopman-Esseboom Corine, van Haastert Inge-Lot C, Benders Manon J N L, Dudink Jeroen 6 jul 2020, In: PLoS ONE.

Morphine affects brain activity and volumes in preterms:An observational multi-center study

Tataranno M L, Gui L, Hellström-Westas L, Toet M, Groenendaal F, Claessens N H P, Schuurmans J, Fellman V, Sävman K, de Vries L S, Huppi P, Benders M J N L 7 apr 2020, In: Early Human Development. 144 8 p.

The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy

Annink Kim V, de Vries Linda S, Groenendaal Floris, Vijlbrief Daniel C, Weeke Lauren C, Roehr Charles C, Lequin Maarten, Reiss Irwin K M, Govaert Paul, Benders Manon J N L, Dudink Jeroen 1 mrt 2020, In: Pediatric Research. 87 , p. 59-66 8 p.

Perinatal thalamic injury: MRI predictors of electrical status epilepticus in sleep and long-term neurodevelopment

van den Munckhof Bart, Zwart Anne F, Weeke Lauren C, Claessens Nathalie H P, Plate Joost D J, Leemans Alexander, Kuijf Hugo J, van Teeseling Heleen C, Leijten Frans S S, Benders Manon J N, Braun Kees P J, de Vries Linda S, Jansen Floor E 25 feb 2020, In: NeuroImage. Clinical. 26 9 p.

Early or later cranial MRI in full-term infants with therapeutic hypothermia:Does it matter?

de Vries Linda S 11 feb 2020, In: European Journal of Paediatric Neurology. 25 , p. 2 1 p.

TMX2 Is a Crucial Regulator of Cellular Redox State, and Its Dysfunction Causes Severe Brain Developmental Abnormalities

Vandervore Laura V, Schot Rachel, Milanese Chiara, Smits Daphne J, Kasteleijn Esmee, Fry Andrew E, Pilz Daniela T, Brock Stefanie, Börklü-Yücel Esra, Post Marco, Bahi-Buisson Nadia, Sánchez-Soler María José, van Slegtenhorst Marjon, Keren Boris, Afenjar Alexandra, Coury Stephanie A, Tan Wen-Hann, Oegema Renske, de Vries Linda S, Fawcett Katherine A, Nikkels Peter G J, Bertoli-Avella Aida, Al Hashem Amal, Alwabel Abdulmalik A, Tlili-Graiess Kalthoum, Efthymiou Stephanie, Zafar Faisal, Rana Nuzhat, Bibi Farah, Houlden Henry, Maroofian Reza, Person Richard E, Crunk Amy, Savatt Juliann M, Turner Lisbeth, Doosti Mohammad, Karimiani Ehsan Ghayoor, Saadi Nebal Waill, Akhondian Javad, Lequin Maarten H, Kayserili Hülya, van der Spek Peter J, Jansen Anna C, Kros Johan M, Verdijk Robert M, Milošević Nataša Jovanov, Fornerod Maarten, Mastroberardino Pier Giorgio, Mancini Grazia M S 5 dec 2019, In: American Journal of Human Genetics. 105 , p. 1126-1147 22 p.

Viral Infections and the Neonatal Brain

de Vries Linda S. 1 dec 2019, In: Seminars in Pediatric Neurology. 32

Neonatal care bundles are associated with a reduction in the incidence of intraventricular haemorrhage in preterm infants:a multicentre cohort study

de Bijl-Marcus Karen, Brouwer Annemieke Johanna, De Vries Linda S, Groenendaal Floris, Wezel-Meijler Gerda van 15 nov 2019, In: Archives of Disease in Childhood Fetal and Neonatal Edition. 105 , p. 419-424 6 p.

Early prediction of unilateral cerebral palsy in infants at risk:MRI versus the hand assessment for infants

Wagenaar Nienke, Verhage Cornelia H, de Vries Linda S, van Gasselt Bram P L, Koopman-Esseboom Corine, Leemans Alexander, Groenendaal Floris, Benders Manon J N L, van der Aa Niek E 13 nov 2019, In: Pediatric Research. 87 , p. 932-939 8 p.

Periventricular Hemorrhagic Infarction in Very Preterm Infants:Characteristic Sonographic Findings and Association with Neurodevelopmental Outcome at Age 2 Years

Cizmeci Mehmet N, de Vries Linda S, Ly Linh G, van Haastert Ingrid C, Groenendaal Floris, Kelly Edmond N, Traubici Jeffrey, Whyte Hilary E, Leijser Lara M 6 nov 2019, In: The Journal of Pediatrics. 217 , p. 79-85.e1

All Research Output (609)