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prof. dr. M.G.E.H. (Marnix) Lam Full Professor

  • Researchgr. Nucleaire Geneeskunde

M.G.E.H. Lam


Research Programs


Marnix Lam (1975) studied Pharmaceutical sciences (passed with distinction) and Medicine at Utrecht University. He became a resident in Nuclear Medicine, respectively Radiology and finalized his PhD thesis (2009) on radionuclide therapy in prostate cancer patients with metastatic bone pain. This was followed by a two-year postdoctoral fellowship at Stanford University School of Medicine, USA. In 2016 he was appointed Professor of Nuclear Medicine.
Translational research in molecular medicine has been the scope of his scientific work, with a focus on oncology. Bringing new radiopharmaceuticals to clinical practice. This specifically resulted in the introduction of new oncological treatment modalities in the Netherlands, such as bone seeking radiopharmaceuticals for the palliation of metastatic bone pain (Sm-153-EDTMP, Re-188-HEDP) and radioembolization for treatment of hepatic malignancies (Y-90 and Ho-166 microspheres). Current research is focussed on dosimetry of therapeutic radiopharmaceuticals, image-guided treatment technology, alfa- and beta-emitting isotopes for therapeutic purposes, intra-arterial and intra-tumor treatment approaches, and radio-immunotherapy.

Side Activities

  • Board Member of the National Education Committee on Nuclear Medicine

    National Coordinator on Education of Gastrointestinal Nuclear Medicine and Musculoskeletal Nuclear Medicine

    Consultant for BTG and Terumo



Fellowship and Awards

  • Alavi-Mandell award for best publication in Journal of Nuclear Medicine: van den Hoven A, Rosenbaum C, Elias S, de Jong H, Koopman M, Verkooijen H, Alavi A, van den Bosch M, Lam MGEH. Insights into the dose-response relationship of radioembolization with resin yttrium-90 microspheres: a prospective cohort study in patients with colorectal cancer liver metastases. J Nucl Med. 2016 Jul;57(7):1014-9. (2017)

    Research grant from the Dutch Cancer Society (KWF): Holmium-166 microspheres for radioembolization in HCC patients: new generation microspheres for individualized treatment (2016)

    Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Prince JF, van Rooij R, Bol GH, de Jong HW, van den Bosch MA, Lam MGEH. Safety of a Scout Dose Preceding Hepatic Radioembolization with 166Ho Microspheres. J Nucl Med. 2015 Jun;56(6):817-23. (2016)

    Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Blomberg BA, Thomassen A, de Jong PA, Simonsen JA, Lam MGEH, Nielsen AL, Mickley H, Mali WP, Alavi A5, Høilund-Carlsen PF. Impact of Personal Characteristics and Technical Factors on Quantification of Sodium 18F-Fluoride Uptake in Human Arteries: Prospective Evaluation of Healthy Subjects. J Nucl Med. 2015 Oct;56(10):1534-40. (2016)

    Research grant from Alpe d’Huzes / Dutch Cancer Society (KWF): Holmium micro-brachytherapy: an innovative intratumoral treatment modality in head and neck cancer (2014)

    Appointed as honorary professor at the medical school of the People’s Liberation Army General Hospital and Military University, Beijing, China (2014)

    CIRSE Award of Excellence and Innovation in Interventional Radiology (2014)

    Research grant from the Dutch Cancer Society (KWF): translational research in oncology (2010)

Research Output (156)

The Efficacy of Coil Embolization to Obtain Intrahepatic Redistribution in Radioembolization:Qualitative and Quantitative Analyses

Alsultan Ahmed A, van Roekel Caren, Barentsz Maarten W, Braat Arthur J A T, van Doormaal Pieter Jan, Lam Marnix G E H, Smits Maarten L J mrt 2020, In: Cardiovascular and Interventional Radiology. 43 , p. 391-401 11 p.

Reply by Authors

van Kalmthout Ludwig W M, van Melick Harm E, Lavalaye Jules, Meijer Richard P, Kooistra Anko, de Klerk John M H, Braat Arthur J A T, Kaldeway H Peter, de Bruin P C, de Keizer Bart, Lam Marnix G E H mrt 2020, In: The Journal of Urology. 203 , p. 545-545

Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy

Braat A J A T, Ahmadzadehfar H, Kappadath S C, Stothers C L, Frilling A, Deroose C M, Flamen P, Brown D B, Sze D Y, Mahvash A, Lam M G E H feb 2020, In: Cardiovascular and Interventional Radiology. 43 , p. 246-253 8 p.

Feasibility of imaging 90 Y microspheres at diagnostic activity levels for hepatic radioembolization treatment planning

Kunnen Britt, Dietze Martijn M A, Braat Arthur J A T, Lam Marnix G E H, Viergever Max A, de Jong Hugo W A M 19 dec 2019, In: Medical Physics. 47 , p. 1105-1114 10 p.

Fast and accurate quantitative determination of the lung shunt fraction in hepatic radioembolization

Bastiaannet Remco, van der Velden Sandra, Lam Marnix G.E.H., Viergever Max A., de Jong Hugo W.A.M. 26 nov 2019, In: Physics in medicine and biology. 64 , p. 235002 11 p.

Quality of life in patients with liver tumors treated with holmium-166 radioembolization

van Roekel Caren, Smits Maarten L J, Prince Jip F, Bruijnen Rutger C G, van den Bosch Maurice A A J, Lam Marnix G E H 15 nov 2019, In: Clinical & Experimental Metastasis. 37 , p. 95-105 11 p.

Personalised radioembolization improves outcomes in refractory intra-hepatic cholangiocarcinoma:a multicenter study

Levillain Hugo, Duran Derijckere Ivan, Ameye Lieveke, Guiot Thomas, Braat Arthur, Meyer Carsten, Vanderlinden Bruno, Reynaert Nick, Hendlisz Alain, Lam Marnix, Deroose Christophe M., Ahmadzadehfar Hojjat, Flamen Patrick 1 okt 2019, In: European Journal of Nuclear Medicine and Molecular Imaging. 46 , p. 2270-2279 10 p.

Evolving Role of PET in Interventional Radiology-Based Oncology Procedures Preface

Lam Marnix G.E.H., Hunt Stephen J., El-Haddad Ghassan E., Alavi Abass 1 okt 2019, In: PET Clinics. 14 , p. xiii-xiv

The Unique Role of Fluorodeoxyglucose-PET in Radioembolization

Bastiaannet Remco, Lodge Martin A., de Jong Hugo W.A.M., Lam Marnix G.E.H. 1 okt 2019, In: PET Clinics. 14 , p. 447-457 11 p.

A Pilot Study on Hepatobiliary Scintigraphy to Monitor Regional Liver Function in Y-90 Radioembolization

Van Der Velden Sandra, Braat Manon N.G.J.A., Labeur Tim A., Scholten Mike V., Van Delden Otto M., Bennink Roelof J., De Jong Hugo W.A.M., Lam Marnix G.E.H. okt 2019, In: Journal of Nuclear Medicine. 60 , p. 1430-1436 7 p.

All Research Output (156)
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