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dr. T.G.W. (Tom) Letteboer

Assistant Professor - medical

  • Section Clinical Genetics

Research Programs

Research Output (53)

Cancer Risks for PMS2-associated lynch syndrom

Broeke Sanne W.Ten, Klift Heleen M.Vander, Tops Carli M.J., Aretz Stefan, Bernstein Inge, Buchanan Daniel D., Chapelle Albert Dela, Capella Gabriel, Clendenning Mark, Engel Christoph, Gallinger Steven, Garcia Encarna Gomez, Figueiredo Jane C., Haile Robert, Hampel Heather L., Hopper John L., Hoogerbrugge Nicoline, Doeberitz Magnus Von Knebel, Marchand Loic Le, Letteboer Tom G.W., Jenkins Mark A., Lindblom Annika, Lindor Noralane M., Mensenkamp Arjen R., Møller Pal, Newcomb Polly A., Van Os Theo A.M., Pearlman Rachel, Pineda Marta, Rahner Nils, Redeker Egbert J.W., Olderode-Berends Maran J.W., Rosty Christophe, Schackert Hans K., Scott Rodney, Senter Leigha, Spruijt Liesbeth, Steinke-Lange Verena, Suerink Manon, Thibodeau Stephen, Vos Yvonne J., Wagner Anja, Winship Ingrid, Hes J. Frederik, Vasen Hans F.A., Wijnen Juul T., Nielsen Maartje, Win Aung Ko 10 okt 2018, In: Journal of Clinical Oncology. 36 , p. 2961-2968 8 p.

SNP association study in PMS2-associated Lynch syndrome

Ten Broeke Sanne W., Elsayed Fadwa A., Pagan Lisa, Olderode-Berends Maran J W, Garcia Encarna Gomez, Gille Hans J J P, van Hest Liselot P., Letteboer Tom G.W., Van Der Kolk Lizet E., Mensenkamp Arjen R., Van Os Theo A., Spruijt Liesbeth, Redeker Bert J W, Suerink Manon, Vos Yvonne J., Wagner Anja, Wijnen Juul T., Steyerberg Ewout W., Tops Carli M J, van Wezel Tom, Nielsen Maartje okt 2018, In: Familial Cancer. 17 , p. 507-515 9 p.

Molecular Background of Colorectal Tumors From Patients With Lynch Syndrome Associated With Germline Variants in PMS2

ten Broeke Sanne W., van Bavel Tom C., Jansen Anne M.L., Gómez-García Encarnca, Hes Frederik J., van Hest Liselot P., Letteboer Tom G.W., Olderode-Berends Maran J.W., Ruano Dina, Spruijt Liesbeth, Suerink Manon, Tops Carli M., van Eijk Ronald, Morreau Hans, van Wezel Tom, Nielsen Maartje 1 sep 2018, In: Gastroenterology. 155 , p. 844-851 8 p.

Sending family history questionnaires to patients before a colonoscopy improves genetic counseling for hereditary colorectal cancer

Kessels Koen, Eisinger Joey D, Letteboer Tom G, Offerhaus G Johan A, Siersema Peter D, Moons Leon M G jun 2017, In: Rare diseases (Austin, Tex.). 18 , p. 343-348 6 p.

Validation of a clinical screening instrument for tumour predisposition syndromes in patients with childhood cancer (TuPS):Protocol for a prospective, observational, multicentre study

Postema Floor A M, Hopman Saskia M J, De Borgie Corianne A J M, Hammond Peter, Hennekam Raoul C., Merks Johannes H M, Aalfs Cora M., Anninga Jakob K., Berger Lieke P V, Bleeker Fonnet E., De Bont Eveline S J M, Dommering Charlotte J., Van Eijkelenburg Natasha K A, Van Den Heuvel-Eibrink Marry M., Jongmans Marjolijn C J, Kors Wijnanda A., Letteboer Tom G W, Loeffen Jan L C M, Olderode-Berends Maran J W, Wagner Anja 1 jan 2017, In: BMJ open [E]. 7

Childhood tumours with a high probability of being part of a tumour predisposition syndrome; reason for referral for genetic consultation

Postema Floor A M, Hopman Saskia M J, Aalfs Cora M, Berger Lieke P V, Bleeker Fonnet E, Dommering Charlotte J, Jongmans Marjolijn C J, Letteboer Tom G W, Olderode-Berends Maran J W, Wagner Anja, Hennekam Raoul C, Merks Johannes H M 2017, In: European Journal of Cancer. 80 , p. 48-54 7 p.

Comprehensive Mutation Analysis of PMS2 in a Large Cohort of Probands Suspected of Lynch Syndrome or Constitutional Mismatch Repair Deficiency (CMMRD) Syndrome

van der Klift Heleen M, Mensenkamp Arjen R, Drost Mark, Bik Elsa C, Vos Yvonne J, Gille Hans J J P, Redeker Bert E J W, Tiersma Yvonne, Zonneveld José B M, García Encarna Gómez, Letteboer Tom G W, Olderode-Berends Maran J W, van Hest Liselotte P, van Os Theo A, Verhoef Senno, Wagner Anja, van Asperen Christi J, Ten Broeke Sanne W, Hes Frederik J, de Wind Niels, Nielsen Maartje, Devilee Peter, Ligtenberg Marjolijn J L, Wijnen Juul T, Tops Carli M J nov 2016, In: Human Mutation. 37 , p. 1162–1179

Colorectal cancer risk variants at 8q23.3 and 11q23.1 are associated with disease phenotype in APC mutation carriers

Ghorbanoghli Z., Nieuwenhuis M. H., Houwing-Duistermaat J. J., Jagmohan-Changur S., Hes F. J., Tops C. M., Wagner A., Aalfs C. M., Verhoef S., Gómez García E. B., Sijmons R. H., Menko F. H., Letteboer T. G., Hoogerbrugge N., van Wezel T., Vasen H. F A, Wijnen J.T. okt 2016, In: Familial Cancer. 15 , p. 563–570 8 p.

Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers

Jansen Anne Ml, van Wezel Tom, van den Akker Brendy Ewm, Ventayol Garcia Marina, Ruano Dina, Tops Carli Mj, Wagner Anja, Letteboer Tom Gw, Gómez-García Encarna B, Devilee Peter, Wijnen Juul T, Hes Frederik J, Morreau Hans jul 2016, In: European Journal of Human Genetics. 24 , p. 1089-1092 4 p.

The effect of genotypes and parent of origin on cancer risk and age of cancer development in PMS2 mutation carriers

Suerink Manon, van der Klift Heleen M, Ten Broeke Sanne W, Dekkers Olaf M, Bernstein Inge, Capellá Munar Gabriel, Gomez Garcia Encarna, Hoogerbrugge Nicoline, Letteboer Tom G W, Menko Fred H, Lindblom Annika, Mensenkamp Arjen, Moller Pal, van Os Theo A, Rahner Nils, Redeker Bert J W, Olderode Maran, Spruijt Liesbeth, Vos Yvonne J, Wagner Anja, Morreau Hans, Hes Frederik J, Vasen Hans F A, Tops Carli M, Wijnen Juul T, Nielsen Maartje apr 2016, In: Genetics in Medicine. 18 , p. 405–409

All Research Output (53)