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prof. dr. R.J. (Jeroen) Pasterkamp Full Professor

  • Translational Neuroscience

R.J. Pasterkamp

Contact

Research Programs

Biography

Jeroen Pasterkamp obtained his PhD degree at the Netherlands Institute for Brain Research and the Vrije Universiteit in Amsterdam with Joost Verhaagen and Dick Swaab. He carried out postdoctoral research at the Department of Neuroscience of the Johns Hopkins University School of Medicine in Baltimore, USA. In 2005, he joined the Department of Translational Neuroscience of the Brain Center Rudolf Magnus, where he is currently appointed as a professor of translational neuroscience.

His research focuses on understanding 1) the signaling events and molecular mechanisms involved in the formation of neuronal connections during development, and 2) the molecular mechanisms underlying changes in or loss of neuronal connectivity during neurological disease (in particular amyotrophic lateral sclerosis (ALS) and epilepsy). This research concentrates on mouse models and humanized cell models (iPSC) using an integrated approach involving molecular biology, cell biology, neuroanatomy, (in vivo) functional proteomics, imaging, HC screening, and mouse genetics.

His work was published in leading journals such as Cell, Journal of Neuroscience, Nature, Nature Genetics, PNAS and he regularly contributes reviews to Current Opinion, Trends and Nature Reviews journals.

Jeroen Pasterkamp is a recipient of a NARSAD Young Investigator, and a Dan Nathans Young Investigator Award. He is a member of the Scientific Advisory board of the Dutch National Epilepsy Fund (NEF) and the Dutch Society for Developmental Biology. He organizes scientific meetings under the framework of the Royal Netherlands Academy of Arts and Sciences (KNAW), EMBO, and Utrecht Summerschool series.

Research line

Neural circuit development and Translational neuroscience

Most recent key publications

1. Vangoor VR, Reschke CR, Senthilkumar K, van de Haar LL, de Wit M, Giuliani G, Broekhoven MH, Morris G, Engel T, Brennan GP, Conroy RM, van Rijen PC, Gosselaar PH, Schorge S, Schaapveld RQJ, Henshall DC, De Graan PNE, Pasterkamp RJ (2019) Antagonizing increased miR-135a levels at the chronic stage of experimental TLE reduces spontaneous recurrent seizures. J Neurosci 39, 5064-5079.
 
2. Ormel PR, Vieira de Sá R, van Bodegraven EJ, Karst H, Harschnitz O, Sneeboer MAM, Johansen LE, van Dijk RE, Scheefhals N, Berdenis van Berlekom A, Ribes Martínez E, Kling S, MacGillavry HD, van den Berg LH, Kahn RS, Hol EM, de Witte LD, Pasterkamp RJ (2018) Microglia innately develop within cerebral organoids. Nat Commun 9, 4167.
 
3. Jongbloets BC, Lemstra S, Schellino R, Broekhoven MH, Parkash J, Hellemons AJ, Mao T, Giacobini P, van Praag H, De Marchis S, Ramakers GM, Pasterkamp RJ (2017) Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nat Commun 8:14666.
 
4. Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ*, Jones EY* (2016). Structural Basis for Plexin Activation and Regulation. Neuron 91, 548-60. *Shared senior authors.
 
5. Harschnitz O, van den Berg LH, Johansen LE, Jansen MD, Kling S, Vieira de Sá R, Vlam L, van Rheenen W, Karst H, Wierenga CJ, Pasterkamp RJ*, van der Pol WL* (2016). Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model. Ann Neurol 80, 71-88. *Shared senior authors.
 
6. Van Erp S, van den Heuvel DMA, Fujita Y, Robinson R, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers J, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ (2015) Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases. Dev Cell 35, 537-552.

Side Activities

  • None.

Fellowship and Awards

  • VICI, 2015
    ZonMW TOP, 2008
    VIDI, 2006
    HFSP career development award, 2005
    VENI, 2004
    NWO Talent, 2000

Research Output (131)

TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells

Wu Bin, Blot François Gc, Wong Aaron Benson, Osório Catarina, Adolfs Youri, Pasterkamp R. Jeroen, Hartmann Jana, Becker Esther Be, Boele Henk Jan, De Zeeuw Chris I., Schonewille Martijn 1 sep 2019, In: eLife. 8

Sensory Axon growth requires spatiotemporal integration of CaSR and TrkB Signaling

Markworth Ronja, Adolfs Youri, Dambeck Vivian, Steinbeck Lars M., Lizé Muriel, Pasterkamp R. Jeroen, Bähr Mathias, Dean Camin, Burk Katja 24 jul 2019, In: Journal of Neuroscience. 39 , p. 5842-5860 19 p.

Antagonizing Increased miR-135a Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures

Vangoor Vamshidhar R., Reschke Cristina R., Senthilkumar Ketharini, van de Haar Lieke L., de Wit Marina, Giuliani Giuliano, Broekhoven Mark H., Morris Gareth, Engel Tobias, Brennan Gary P., Conroy Ronan M., van Rijen Peter C., Gosselaar Peter H., Schorge Stephanie, Schaapveld Roel Q.J., Henshall David C., De Graan Pierre N.E., Pasterkamp R. Jeroen 26 jun 2019, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39 , p. 5064-5079 16 p.

Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis

De Santis Riccardo, Alfano Vincenzo, de Turris Valeria, Colantoni Alessio, Santini Laura, Garone Maria Giovanna, Antonacci Giuseppe, Peruzzi Giovanna, Sudria-Lopez Emma, Wyler Emanuel, Anink Jasper J., Aronica Eleonora, Landthaler Markus, Pasterkamp R. Jeroen, Bozzoni Irene, Rosa Alessandro 25 jun 2019, In: Cell Reports. 27 , p. 3818-3831.e5

Axons Navigate Noise with 190RhoGAP

Zelina Pavol, Pasterkamp R. Jeroen 8 mei 2019, In: Neuron. 102 , p. 512-514 3 p.

HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

Riemslagh Frederike W., Lans Hannes, Seelaar Harro, Severijnen Lies Anne W.F.M., Melhem Shamiram, Vermeulen Wim, Aronica Eleonora, Pasterkamp R. Jeroen, van Swieten John C., Willemsen Rob 13 mrt 2019, In: Acta neuropathologica communications. 7

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

Burk Katja, Pasterkamp R. Jeroen 5 feb 2019, In: Acta Neuropathologica. 137 , p. 859-877 19 p.

Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers

Frick Petra, Sellier Chantal, Mackenzie Ian R.A., Cheng Chieh Yu, Tahraoui-Bories Julie, Martinat Cecile, Pasterkamp R. Jeroen, Prudlo Johannes, Edbauer Dieter, Oulad-Abdelghani Mustapha, Feederle Regina, Charlet-Berguerand Nicolas, Neumann Manuela 3 aug 2018, In: Acta neuropathologica communications. 6 , p. 72 1 p.

The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development

Cunha-Ferreira Inês, Chazeau Anaël, Buijs Robin R., Stucchi Riccardo, Will Lena, Pan Xingxiu, Adolfs Youri, van der Meer Christiaan, Wolthuis Joanna C., Kahn Olga I., Schätzle Philipp, Altelaar Maarten, Pasterkamp R. Jeroen, Kapitein Lukas C., Hoogenraad Casper C. 24 jul 2018, In: Cell Reports. 24 , p. 791-800 10 p.

Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy

Dazzo Emanuela, Rehberg Kati, Michelucci Roberto, Passarelli Daniela, Boniver Clementina, Vianello Dri Valeria, Striano Pasquale, Striano Salvatore, Pasterkamp R. Jeroen, Nobile Carlo 1 mrt 2018, In: Annals of Neurology. 83 , p. 483-493

All Research Output (131)
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