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dr. A.J. (Alex) Poot

dr. A.J. (Alex) Poot

Associate Professor

Research Programs

Cancer

Biography

Biography

Associate Professor, Head of Radionuclide Pharmacy

Research interests:

- Development of theranostics for (pediatric) cancer

- Radiochemistry

- Clinical translation and implementation

- GMP

Department:

Nucleaire Geneeskunde, Radionucliden Apotheek

Radionuclide pharmacy (text in Dutch):

De radionuclide apotheek richt zich op de ontwikkeling en klinische translatie van radioactief gelabelde moleculen voor diagnostiek en therapie, ook wel theranostics genoemd. De ontwikkeling van theranostics gaan in hoog tempo. Ondanks de grote potentie die theranostics hebben is hier voor kinderkanker nauwelijks nog aandacht voor. In een samenwerking tussen het UMC Utrecht en het Prinses Maxima Centrum richt het theranostics programma zich op deze klinische behoefte voor betere nucleaire diagnostiek en de ontwikkeling van innovatieve nucleaire behandelmogelijkheden voor kinderkanker.

Publications

- See PubMed >

- See Web of science >

Associate Professor lecture (2021) >

Research Output (19)

Follicle-Stimulating Hormone Receptor Expression and Its Potential Application for Theranostics in Subtypes of Ovarian Tumors:A Systematic Review

Bakker Marie Christine E., Brink Geertruid J., Poot Alex J., Braat Arthur J.A.T., Jonges Geertruida N., Zweemer Ronald P. Mar 2024, In: Cancers. 16

Synthesis and Preclinical Evaluation of [Methylpiperazine-11C]brigatinib as a PET Tracer Targeting Both Mutated Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase.

Högnäsbacka Antonia A, Poot Alex J, Kooijman Esther, Schuit Robert C, Schreurs Maxime, Verlaan Mariska, Beaino Wissam, van Dongen Guus A M S, Vugts Danielle J, Windhorst Albert D 14 Sep 2023, In: Journal of Medicinal Chemistry. 66 , p. 12130-12140 11 p.

Synthesis and preclinical evaluation of two osimertinib isotopologues labeled with carbon-11 as PET tracers targeting the tyrosine kinase domain of the epidermal growth factor receptor

Högnäsbacka Antonia, Poot Alex J, Kooijman Esther, Schuit Robert C, Schreurs Maxime, Verlaan Mariska, van den Hoek Johan, Heideman Daniëlle A M, Beaino Wissam, van Dongen Guus A M S, Vugts Danielle J, Windhorst Albert D 4 May 2023, In: Nuclear medicine and biology. 120-121

Imaging the TGFβ type I receptor in pulmonary arterial hypertension

Rotteveel Lonneke, Poot Alex J, Kooijman Esther J M, Schuit Robert C, Schalij Ingrid, Sun Xiaoqing, Kurakula Kondababu, Happé Chris, Beaino Wissam, Ten Dijke Peter, Lammertsma Adriaan A, Bogaard Harm Jan, Windhorst Albert D 22 Mar 2023, In: EJNMMI Research. 13 , p. 23

Evaluating the Targeting of a Staphylococcus-aureus-Infected Implant with a Radiolabeled Antibody In Vivo

van Dijk Bruce, Hooning van Duyvenbode J. Fred F., de Vor Lisanne, Nurmohamed F. Ruben H.A., Lam Marnix G.E.H., Poot Alex J., Ramakers Ruud M., Koustoulidou Sofia, Beekman Freek J., van Strijp Jos, Rooijakkers Suzan H.M., Dadachova Ekaterina, Vogely H. Charles, Weinans Harrie, van der Wal Bart C.H. Mar 2023, In: International journal of molecular sciences. 24 , p. 1-9 9 p.

Correction to:[ <sup>18</sup>F]mFBG PET‑CT for detection and localisation of neuroblastoma: a prospective pilot study (European Journal of Nuclear Medicine and Molecular Imaging, (2023), 50, 4, (1146-1157), 10.1007/s00259-022-06063-6)

Samim Atia, Blom Thomas, Poot Alex J, Windhorst Albert D, Fiocco Marta, Tolboom Nelleke, Braat Arthur J A T, Viol Sebastiaan L Meyer, van Rooij Rob, van Noesel Max M, Lam Marnix G E H, Tytgat Godelieve A M, de Keizer Bart 18 Feb 2023, In: European Journal of Nuclear Medicine and Molecular Imaging. 50 , p. 1-1 1 p.

Sentinel lymph node detection in thyroid carcinoma using [ 68Ga]Ga-tilmanocept PET/CT:a proof-of-concept study.

de Vries Lisa H, Lodewijk Lutske, Ververs Tessa, Poot Alex J, van Rooij Rob, Brosens Lodewijk A A, de Krijger Ronald R, Rinkes Inne H M Borel, Vriens Menno R, de Keizer Bart 2023, In: European Journal of Nuclear Medicine and Molecular Imaging. 51 , p. 512-520 9 p.

Biologicals as theranostic vehicles in paediatric oncology

Niessen Veerle J A, Wenker Sylvia T M, Lam Marnix G E H, van Noesel Max M, Poot Alex J 14 Sep 2022, In: Nuclear medicine and biology. 114-115 , p. 58-64 7 p.

Synthesis and preclinical evaluation of [ <sup>11</sup>C]LR111 and [ <sup>18</sup>F]EW-7197 as PET tracers of the activin-receptor like kinase-5

Rotteveel Lonneke, Kurakula Kondababu, Kooijman Esther J. M., Schuit Robert C., Verlaan Mariska, Schreurs Maxime, Beaino Wissam, van Dinther Maarten A. H., ten Dijke Peter, Lammertsma Adriaan A., Poot AJ, Bogaard Harm Jan, Windhorst Albert D. 1 Sep 2022, In: Nuclear medicine and biology. 112-113 , p. 9-19 11 p.

Fibroblast activation protein identifies Consensus Molecular Subtype 4 in colorectal cancer and allows its detection by 68Ga-FAPI-PET imaging

Strating Esther, Wassenaar Emma, Verhagen Mathijs, Rauwerdink Paulien, van Schelven Susanne, de Hingh Ignace, Rinkes Inne Borel, Boerma Djamila, Witkamp Arjen, Lacle Miangela, Fodde Riccardo, Volckmann Richard, Koster Jan, Stedingk Kris, Giesel Frederik, de Roos Remmert, Poot Alex, Bol Guus, Lam Marnix, Elias Sjoerd, Kranenburg Onno 1 Jul 2022, In: British Journal of Cancer. 127 , p. 145-155 11 p.

All research output

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