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drs. H. (Holger) Rehmann

Assistant Professor

  • Group Burgering, section Molecular Cancer Research

drs. H. (Holger) Rehmann

Research Programs

Biography

Rehmann studied biochemistry at the Ruhr-Universität Bochum, where he graduated as as Diplom-Biochemiker in 1999. He prepared his doctoral thesis at the Max-Planck-Institut für Molekulare Physiologie in Dortmund and defended his thesis at the Universiteit Utrecht with the predicate cum laude in 2003. He joined the group of J.L. Bos at the UMC Utrecht as postdoctoral fellow and investigated the structural basis for the regulation of the Epac proteins, resulting among others in two publications in nature. He was appointed as Assistant Professor at the UMC Utrecht in 2007 and became associated member of the Bijvoet Center in 2010. In the last years Rehmann developed chemically modified analogues of the natural small molecule cAMP. These analogues are able to activate selectively the Epac2 protein, which is involved in the potentiation of glucose induced insulin secretion. Rehmann is currently evaluating the Epac2 protein as a putative target for the treatment of diabetes. In course of these efforts he has recently started a collaboration with the European Lead Factory.

Side Activities

  • None

Fellowship and Awards

  • 2004    Otto-Hahn-Medaille of the Max-Planck-Gesellschaft

    2004    Mention for the doctoral thesis by the de Girard de Mielet van Coehoorn stichting

    2007    Hendrik Casimir-Karl Ziegler-Forschungspreis of the Nordrhein-Westfälische Akademie der Wissenschaften and the Koninklijke Nederlandse Akademie van Wetenschappen

    2007    VENI

    2010    Stimuleringssubsidie of the Universiteit Utrecht

Research Output (66)

De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia

Haijes Hanneke A., Koster Maria J.E., Rehmann Holger, Li Dong, Hakonarson H., Cappuccio Gerarda, Hancarova Miroslava, Lehalle Daphne, Reardon Willie, Schaefer G. Bradley, Lehman Anna, van de Laar Ingrid M.B.H., Tesselaar Coranne D., Turner Clesson, Goldenberg A., Patrier Sophie, Thevenon Julien, Pinelli Michele, Brunetti-Pierri Nicola, Prchalová Darina, Havlovicová Markéta, Vlckova Markéta, Sedláček Zdeněk, Lopez E., Ragoussis Vassilis, Pagnamenta Alistair T., Kini Usha, Vos Harmjan R., van Es Robert M., van Schaik Richard F.M.A., van Essen Ton A.J., Kibaek M., Taylor Jenny C., Sullivan Jennifer, Shashi Vandana, Petrovski S., Fagerberg Christina, Martin Donna M., van Gassen Koen L.I., Pfundt R., Falk Marni J., McCormick Elizabeth M., Timmers H. T.Marc, van Hasselt Peter M. 1 aug 2019, In: American Journal of Human Genetics. 105 , p. 283-301 19 p.

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

Rumping Lynne, Tessadori Federico, Pouwels Petra J.W., Vringer Esmee, Wijnen Jannie P., Bhogal Alex A., Savelberg Sanne M.C., Duran Karen J., Bakkers Mark J.G., Ramos Rúben J.J., Schellekens Peter A.W., Kroes Hester Y., Klomp Dennis W.J., Black Graeme C.M., Taylor Rachel L., Bakkers Jeroen P.W., Prinsen Hubertus C.M.T., van der Knaap Marjo S., Dansen Tobias B., Rehmann Holger, Zwartkruis Fried J.T., Houwen Roderick H.J., van Haaften Gijs, Verhoeven-Duif Nanda M., Jans Judith J.M., van Hasselt Peter M. 1 jan 2019, In: Human Molecular Genetics. 28 , p. 96-104 9 p.

Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy

Rumping Lynne, Büttner Benjamin, Maier Oliver, Rehmann Holger, Lequin Maarten, Schlump Jan Ulrich, Schmitt Bernhard, Schiebergen-Bronkhorst Birgit, Prinsen Hubertus C.M.T., Losa Michele, Fingerhut Ralph, Lemke Johannes R., Zwartkruis Fried J.T., Houwen Roderick H.J., Jans Judith J.M., Verhoeven-Duif Nanda M., Van Hasselt Peter M., Jamra Rami 21 dec 2018, In: JAMA Neurology. 76 , p. 342-350 9 p.

Ras Association-Domain Dimers Bring Proteins Together

Rehmann Holger, Bos Johannes L 6 dec 2016, In: Structure. 24 , p. 2039-2040 2 p.

The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity

Popovic Milica, Schouten Arie, Rensen-de Leeuw Marije, Rehmann Holger 1 feb 2016, In: Journal of Structural Biology. 193 , p. 106-114 9 p.

The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex

van den Berg Maaike C W, van Gogh Inkie J A, Smits Alida M M, van Triest Miranda, Dansen Tobias B, Visscher Marieke, Polderman Paulien E, Vliem Marjolein J, Rehmann Holger, Burgering Boudewijn M T 15 jan 2016, In: Journal of Biological Chemistry. 291 , p. 1200

Efficient intracellular delivery of native proteins

D'Astolfo Diego S, Pagliero Romina J, Pras Anita, Karthaus Wouter R, Clevers Hans, Prasad Vikram, Lebbink Robert Jan, Rehmann Holger, Geijsen Niels 23 apr 2015, In: Cell. 161 , p. 674-90 17 p.

Structure-Guided Design of Selective Epac1 and Epac2 Agonists

Schwede Frank, Bertinetti Daniela, Langerijs Carianne N., Hadders Michael A., Wienk Hans, Ellenbroek Johanne H., de Koning Eelco J P, Bos Johannes L., Herberg Friedrich W., Genieser Hans Gottfried, Janssen Richard A J, Rehmann Holger 1 jan 2015, In: PLoS Biology. 13 26 p.

Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes

Pereira Laëtitia, Rehmann Holger, Lao Dieu Hung, Erickson Jeffrey R, Bossuyt Julie, Chen Ju, Bers Donald M 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112 , p. 3991-6 6 p.

All Research Output (66)