drs. H. (Holger) Rehmann Assistant Professor
- Group Burgering, section Molecular Cancer Research
Rehmann studied biochemistry at the Ruhr-Universität Bochum, where he graduated as as Diplom-Biochemiker in 1999. He prepared his doctoral thesis at the Max-Planck-Institut für Molekulare Physiologie in Dortmund and defended his thesis at the Universiteit Utrecht with the predicate cum laude in 2003. He joined the group of J.L. Bos at the UMC Utrecht as postdoctoral fellow and investigated the structural basis for the regulation of the Epac proteins, resulting among others in two publications in nature. He was appointed as Assistant Professor at the UMC Utrecht in 2007 and became associated member of the Bijvoet Center in 2010. In the last years Rehmann developed chemically modified analogues of the natural small molecule cAMP. These analogues are able to activate selectively the Epac2 protein, which is involved in the potentiation of glucose induced insulin secretion. Rehmann is currently evaluating the Epac2 protein as a putative target for the treatment of diabetes. In course of these efforts he has recently started a collaboration with the European Lead Factory.
Fellowship and Awards
2004 Otto-Hahn-Medaille of the Max-Planck-Gesellschaft
2004 Mention for the doctoral thesis by the de Girard de Mielet van Coehoorn stichting
2007 Hendrik Casimir-Karl Ziegler-Forschungspreis of the Nordrhein-Westfälische Akademie der Wissenschaften and the Koninklijke Nederlandse Akademie van Wetenschappen
2010 Stimuleringssubsidie of the Universiteit Utrecht