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prof. dr. S.H.M. Rooijakkers Full Professor

  • Department of Medical Microbiology

S.H.M. Rooijakkers

Contact

Research Programs

Biography

The goal of the research of Susan Rooijakkers is to unravel the molecular mechanisms underlying bacterial killing by the human immune system. In particular, she investigates the molecular functioning of the complement system, a large protein network in plasma that plays an essential role in the immune response against all invading bacteria. Complement rapidly labels bacteria for phagocytosis by immune cells and directly kills Gram-negative bacteria via pore formation (Membrane Attack Complex (MAC)). Although the MAC is an evolutionary conserved mechanism to kill bacterial cells, we currently do not understand how complement activation results in bacterial killing. In 2015, she obtained the prestigious ERC Starting grant that is aimed at providing insight into these bacterial killing mechanisms. She has recently established novel methods to study complement activation in highly purified model systems allowing us to provide insight into MAC-dependent killing of bacteria.

Other projects in the lab involve unravelling processes underlying complement-mediated phagocytosis. Complement is essential in immune eradication of Gram-positive bacteria. She aims to elucidate the molecular details of complement opsonin-receptor interactions . The work will pave the way for several therapeutic applications, including targeted complement-dependent cytotoxicity (CDC) and antibody therapy of clinically important Gram-positive bacteria. Furthermore, her studies will create new avenues for blocking the undesired complement activation during systemic bacterial infections and sepsis.

Side Activities

  • Academic activities

    Academic editor of Plos One.

    Reviewer of international peer-reviewed journals: Nature, Plos Pathogens, Journal of Immunology, Infection and Immunity, Cell Host&Microbe, Journal of Innate Immunity, Clinical Microbiology and Infection, Molecular Microbiology.

    Official reviewer for Molecular Immunology.

    Organizer of the 13th European Meeting on complement in human disease, August 2011, Leiden, The Netherlands.

    Organization of annual retreats for post-docs of the Eijkman School for Immunology and Infectious diseases.

    Member of the PhD-education committee of the Eijkman Postgraduate School for Immunology and Infectious diseases.

    Panel member of the excecutive committe of the 'Complement UK research network', a collaborative organization that joints over 40 PIs (representing 29 UK Centers). My role as a panel member is to recruit PhD students for open positions (May 2016)

    Board member NADP, Ministerie van Volksgezondheid Welzijn en Sport. Remark, compensation in favor of research group at UMCU.

    Committee member of NWO-ZonMw Veni program  From september 1th 2019 till present day). Remark, compensation in favor of research group at UMCU.

    Opponent at PhD thesis defenses outside the Netherlands.

    • PhD opponent of Anne Rosbjerg, candidate of Professor Peter Garred, University of Copenhagen (August 2018)
    • PhD opponent of Espen Waage Skjeflo, candidate of Professor Tom Erik Moones, University of Bodo (November 2018)
    • PhD opponent of Janus Schatz-Jakobsen, candidate of Professor Gregers Rom Andersen, Department of Molecular Biology and Genetics, Aarhus University (September 2016)
    • External examiner of PhD thesis of Weilin Li, University of Auckland, New Zealand (September 2014)

Fellowship and Awards

  • Research Grants

    March 2015     €1.500.000,- personal ERC Starting grant from European Research Council.

    Feb 2013          Co-applicant on a €800.000,- Eurostars grant together with Pepscan Therapeutics and   Bicycle Therapeutics (#E7679, BAIT, Bicycle Anti-Inflammatory Therapeutics).

    Oct 2011          €100.000,- Aspasia-grant from NWO.

    Nov 2010         €800.000,- personal VIDI-grant for Innovational Research Incentives from NWO (Netherlands Organization for Scientific Research) (#917-11-379).

    Nov 2008         European Molecular Biology Organization (EMBO) long term fellowship (#ALTF 382-2008).

    Jan 2007          €200.000,- personal VENI-grant for Innovational Research Incentives from NWO (Netherlands Organization for Scientific Research) (#916-76-037).

     

     

Research Output (52)

Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics

Heesterbeek D. A.C., Martin N. I., Velthuizen A., Duijst M., Ruyken M., Wubbolts R., Rooijakkers S. H.M., Bardoel B. W. 1 dec 2019, In: Scientific Reports. 9 10 p.

Publisher Correction:Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics (Scientific Reports, (2018), 8, 1, (15409), 10.1038/s41598-018-33850-9)

Heesterbeek D. A.C., Martin N. I., Velthuizen A., Duijst M., Ruyken M., Wubbolts R., Rooijakkers S. H.M., Bardoel B. W. 1 dec 2019, In: Scientific Reports. 9

Differential antibacterial control by neutrophil subsets

Leliefeld Pieter H C, Pillay Janesh, Vrisekoop Nienke, Heeres Marjolein, Tak Tamar, Kox Matthijs, Rooijakkers Suzan H M, Kuijpers Taco W, Pickkers Peter, Leenen Luke P H, Koenderman Leo 12 jun 2018, In: Blood Advances. 2 , p. 1344-1355 12 p.

Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus aureus strains

De Jong Nienke W.M., Vrieling Manouk, Garcia Brandon L., Koop Gerrit, Brettmann Matt, Aerts Piet C., Ruyken Maartje, Van Strijp Jos A.G., Holmes Mark, Harrison Ewan M., Geisbrecht Brian V., Rooijakkers Suzan H.M. 23 mrt 2018, In: Journal of Biological Chemistry. 293 , p. 4468-4477 10 p.

Staphylococcal protein Ecb impairs complement receptor-1 mediated recognition of opsonized bacteria

Amdahl Hanne, Haapasalo Karita, Tan Lydia, Meri Taru, Kuusela Pentti I., Van Strijp Jos A., Rooijakkers Suzan, Jokiranta T. Sakari 1 mrt 2017, In: PLoS ONE [E]. 12

Let's tie the knot:Marriage of complement and adaptive immunity in pathogen evasion, for better or worse

Bennett Kaila M., Rooijakkers Suzan H.M., Gorham Ronald D. 31 jan 2017, In: Frontiers in Microbiology. 8

The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis

Kuipers Annemarie, Stapels Daphne A.C., Weerwind Lleroy T., Ko Ya Ping, Ruyken Maartje, Lee Jean C., van Kessel Kok P.M., Rooijakkers Suzan H.M. 1 jul 2016, In: Microbiology (United Kingdom). 162 , p. 1185-1194 10 p.

Staphylococcus aureus protects its immune-evasion proteins against degradation by neutrophil serine proteases

Stapels D A C, Kuipers A, von Köckritz-Blickwede M, Ruyken M, Tromp A T, Horsburgh M J, de Haas C J C, van Strijp J A G, van Kessel K P M, Rooijakkers S H M apr 2016, In: Cellular microbiology. 18 , p. 536–545

Classical and lectin complement pathway activity in polyneuropathy associated with IgM monoclonal gammopathy

Stork Abraham C J , Cats Elisabeth A., Vlam Lotte, Heezius Erik, Rooijakkers Suzan, Herpers Bjorn, de Jong Ben A W, Rijkers Ger, van Strijp Jos, Notermans Nicolette C, van den Berg Leonard H, van der Pol W-Ludo 15 jan 2016, In: Journal of Neuroimmunology. 290 , p. 76-9 4 p.

Effective Neutrophil Phagocytosis of Aspergillus fumigatus Is Mediated by Classical Pathway Complement Activation

Braem Steven G E, Rooijakkers Suzan H M, Van Kessel Kok P M, De Cock Hans, Wösten Han A B, Van Strijp Jos A G, Haas Pieter Jan A 22 jul 2015, In: Journal of Innate Immunity. 7 , p. 364-374 11 p.

All Research Output (52)
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