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drs. L.M. (Linda M.) Slingerland-Peelen Associate Professor

  • Department of Epidemiology
  • Julius Center Research Program Methodology

L.M. Peelen


Research Programs


After obtaining my PhD in Medical Informatics on modeling dynamics of disease (University of Amsterdam, 2009), I focused my research on risk prediction in clinical epidemiology.

I am appointed in the Methodology research programme at the Julius Center, working on methods for development, validation and implementation of prediction models in complex settings. I am particularly interested in modeling care trajectories, repeated measurements, patient monitoring, and incorporating treatment in prediction models.

With these methods, I contribute to applications in various clinical domains, for example the prediction of complications in diabetes patients (CTMM, DIAMANT).

I am also appointed as methodological staff member at the Division of Anesthesiology, Intensive Care, and Emergency Medicine, where I supervise MSc and PhD students and participate as a methodological sparring partner in the research groups Heart at Risk, Brain at Risk , and Patient monitoring.
The complexity of data and decision strategies in acute and perioperative care require complex methodology and creative solutions, which makes this an attractive field for a methodologist like me.

Also I enjoy teaching epidemiology and related disciplines in various programs of the Graduate School of Life Sciences at Utrecht University, and supervising MSc students (both Medicine and Epidemiology) in their research projects.


Side Activities

  • None

Fellowship and Awards

  • None

Research Output (157)

Accounting for time-dependent treatment use when developing a prognostic model from observational data:A review of methods

Pajouheshnia Romin, Schuster Noah A., Groenwold Rolf H.H., Rutten Frans H., Moons Karel G.M., Peelen Linda M. 1 feb 2020, In: Statistica Neerlandica. 74 , p. 38-51 14 p.

Incorporating repeated measurements into prediction models in the critical care setting:a framework, systematic review and meta-analysis

Plate Joost D J, van de Leur Rutger R, Leenen Luke P H, Hietbrink Falco, Peelen Linda M, Eijkemans M J C 26 okt 2019, In: BMC Medical Research Methodology. 19

Prediction models for the risk of diabetic foot in people with type 2 diabetes: a systematic review and external validation study

Beulens J. W., Yauw J. S., Peelen L. M., Feenstra T. L., Moons K. G., Slieker R. C., Herings R. M., Elders P. J., Nijpels G., van der Heijden A. A. sep 2019, In: Diabetologia. 62 , p. S459-S460

Prediction of macrovascular events and mortality in people with type 2 diabetes using dynamic modelling of systolic blood pressure: the Hoorn Diabetes Care System cohort

Nijpels G., Yauw J., Feenstra T., Baan C., Beulens J., Elders P., Herings R., Moons K., Slieker R., Peelen L., van der Heijden A. sep 2019, In: Diabetologia. 62 , p. S573-S573

When and how to use data from randomised trials to develop or validate prognostic models

Pajouheshnia Romin, Groenwold Rolf H.H., Peelen Linda M., Reitsma Johannes B., Moons Karel G.M. 29 mei 2019, In: The BMJ. 365

Adjusting for Disease Severity Across ICUs in Multicenter Studies

Brakenhoff Timo B, Plantinga Nienke L, Wittekamp Bastiaan H J, Cremer Olaf, de Lange Dylan W, de Keizer Nicolet F, Bakhshi-Raiez Ferishta, Groenwold Rolf H H, Peelen Linda M 24 mei 2019, In: Critical Care Medicine. 47 , p. e662-e668

Causes and prevention of postoperative myocardial injury

Verbree-Willemsen Laura, Grobben Remco B., van Waes Judith A.R., Peelen Linda M., Nathoe Hendrik M., van Klei Wilton A., Grobbee Diederick E. 1 jan 2019, In: European Journal of Preventive Cardiology. 26 , p. 59-67 9 p.

Post Hoc Power Calculation:Observing the Expected

Plate Joost D.J., Borggreve Alicia S., van Hillegersberg Richard, Peelen Linda M. 1 jan 2019, In: Annals of Surgery. 269 , p. e11 1 p.

Blood Pressure and End-tidal Carbon Dioxide Ranges during Aneurysm Occlusion and Neurologic Outcome after an Aneurysmal Subarachnoid Hemorrhage

Akkermans Annemarie, van Waes Judith A., Peelen Linda M., Rinkel Gabriel J., van Klei Wilton A. 1 jan 2019, In: Anesthesiology. 130 , p. 92-105 14 p.

Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis:A matched cohort study

Van De Groep K., Nierkens Stefan, Cremer Olaf L., Peelen Linda M., Klein Klouwenberg Peter M.C., Schultz Marcus J., Hack C. Erik, Van Der Poll Tom, Bonten Marc J.M., Ong David S.Y., De Beer Friso M., Bos Lieuwe D.J., Glas Gerie J., Hoogendijk Arie J., Van Hooijdonk Roosmarijn T.M., Horn Janneke, Huson Mischa A., Juffermans Nicole P., Schouten Laura R.A., Scicluna Brendon, Straat Marleen, Van Vught Lonneke A., Wieske Luuk, Wiewel Maryse A., Witteveen Esther, Frencken Jos F., Van De Groep K., Koster-Brouwer Maria E., Varkila Meri R.J., Verboom Diana M. 18 dec 2018, In: Critical Care. 22

All Research Output (157)
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