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prof. dr. J.P.G. (Joost P.G.) Sluijter Full Professor

  • Onderzoek Cardiovasculair Reg. Med.

J.P.G. Sluijter

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Research Programs

Biography

Since March 2008, Joost Sluijter is leading a research group in the University Medical Center Utrecht (UMCU) that is focused on cardiac regeneration. We focus on different approaches that can lead to improved recovery and diagnosis of cardiac tissue upon injury. The main theme reflect the improvement of progenitor cell transplantation therapy by genetic (microRNA) or pharmacological approaches to improve cell survival, optimize cell delivery techniques, improve cell culture conditions and visualization of transplanted cells via MRI, BLI or nuclear labeling. The applicant started to study the use of exosomes to induce cardiac repair in recent years, thereby focusing on paracrine signaling of transplanted cells and their potential effectors. His enthusiasm for introducing innovative molecular approaches, and his wide experiences in progenitor cell biology and preclinical animal model testing for cardiac injury, is aimed for a quick translation from basic discoveries to preclinical testing in patient relevant animal models.

Side Activities

  • -Nucleus member working group on Cellular Biology of the Heart (European Society of Cardiology)

    - Immediate past-Chair working group on Cellular Biology of the Heart (European Society of Cardiology)

    - Board member of the Council on Basic Cardiovascular Science (European Society of Cardiology)

    - Associate editor of Journal of Cardiovascular Translational Research

    - Associate Editor Discovery Biology and Medicine 

    - Editorial Board member of Non-coding RNA Investigation

    - Scientific reviewer for journal (selected): Arterioslerosis, Thrombosis and Vascular biology (ATVB),   American Journal of Physiology, British Journal of Pharmacology, Cardiovascular research (Card Res), Circulation (Circ), Circulation research (Circ Res), Clinical Science, Current Pharmaceutical Design, European Heart Journal (EHJ), Journal of the American College of Cardiology (JACC), Journal of Cellular and Molecular Medicine (JCMM), New England Journal of Medicine (NEJoM), Physiological Genomics, Plos One, Stem Cells International, Science.

    - Scientific reviewer for grant providers (selected): Dutch Heart Foundation, NWO, Foundation de Cooperation Scientifique Campus Paris Saclay (FCS, France), Health and Medical Research Fund (China), Danish Council for Independent Research, National Center of Science and Technology Evaluation (Kazachstan), Medical Research Council (UK), Sir Henry Dale Fellowship (UK), Science foundation of Ireland

     - Lecturer teaching program of undergraduate students at the Faculty of Medicine, Utrecht University.

    - University Utrecht - advisory board for ERC Starting and consolidator Grant-candidates

    - Advisory Board van de Graduate School of Life Sciences University Utrecht

Fellowship and Awards

  • 2004-2005 Interuniversity Institute of the Netherlands (ICIN)-fellowship

    2007-2009 Novartis Foundation for Cardiovascular Excellence Grant

    2008-2009 van Ruyvenstichting

    2009-2012 UMC Utrecht focus and mass area “cardiovascular research”

    2010-2014 BMM-YIC

    2011-2015 Translationeel Adult Stamcelonderzoek:

    2012-2017 HUMAN STem cells for CArdiac REpair (HUSTCARE)

    2014-2018 LSH Impuls: MIGRATE

    2015-2017: BMM Smartcare2 – Smart microtissues for cardiac regeneration

    2015-2019: Horizon 2020 – TECHNOBEAT (PHC-16-2015)

    2015-2018: CAS-NWO Program; Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathy

    2017-2022: Horizon 2020 - ERC-2016-CoG – 725229:  EVICARE: Extracellular Vesicle-Inspired CArdiac Repair

Research Output (206)

Polymeric siRNA gene delivery- transfection efficiency versus cytotoxicity

Sluijter Joost P.G., Kargaard A, Klumperman B. 28 dec 2019, In: Journal of Controlled Release. 316 , p. 263-291 29 p.

Biofabrication of Cell-Derived Nanovesicles: A Potential Alternative to Extracellular Vesicles for Regenerative Medicine

Ilahibaks Nazma, Lei Zhiyong, Deshantri AK, Jiang L, Schiffelers Raymond, Vader Pieter, Sluijter Joost P.G., Mol Emma nov 2019, In: Cells. 8

Injectable Supramolecular Ureidopyrimidinone Hydrogels Provide Sustained Release of Extracellular Vesicle Therapeutics

Mol Emma A, Lei Zhiyong, Roefs Marieke T, Bakker Maarten H, Goumans Marie-José, Doevendans Pieter A, Dankers Patricia Y W, Vader Pieter, Sluijter Joost P G okt 2019, In: Advanced Healthcare Materials. 8

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Jansen Jitske, Jansen Katja, Neven Ellen, Poesen Ruben, Othman Amr, van Mil Alain, Sluijter Joost, Torano Javier Sastre, Zaal Esther A., Berkers Celia R., Esser Diederik, Wichers Harry J., van Ede Karin, van Duursen Majorie, Burtey Stéphane, Verhaar Marianne C., Meijers Björn, Masereeuw Rosalinde 24 jul 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116 , p. 16105-16110 6 p.

Drug Delivery with Extracellular Vesicles:From Imagination to Innovation

De Jong Olivier G., Kooijmans Sander A.A., Murphy Daniel E., Jiang Linglei, Evers Martijn J.W., Sluijter Joost P.G., Vader Pieter, Schiffelers Raymond M. jul 2019, In: ACCOUNTS OF CHEMICAL RESEARCH. 52 , p. 1761-1770 10 p.

Integrated analysis of transcriptional regulation in PLN R14del cardiomyopathy

Pei J., Harakalova M., Nagyova E., Gho J. M. I. H., Sepehrkhouy S., van Dinter J., van Mil A., Buijsrogge M. P., de Jonge N., Huibers M. M., Nieuwenhuis E. E. S., den Ruijter H. M., Pasterkamp G., Doevendans P. A., Hajjar R., Mercola M., Sluijter J. P. G., de Weger R. A., Cheng C., Vink A., Mokry M., Asselbergs F. W. jul 2019, In: European Journal of Human Genetics. 27 , p. 790-791

Circadian rhythms and the molecular clock in cardiovascular biology and disease

Crnko Sandra, Du Pré Bastiaan C, Sluijter Joost P G, Van Laake Linda W jul 2019, In: Nature Reviews Cardiology. 16 , p. 437-447 11 p.

Anti-fibrotic Effects of Cardiac Progenitor Cells in a 3D-Model of Human Cardiac Fibrosis

Bracco Gartner Tom C L, Deddens Janine C, Mol Emma A, Magin Ferrer Marina, van Laake Linda W, Bouten Carlijn V C, Khademhosseini Ali, Doevendans Pieter A, Suyker Willem J L, Sluijter Joost P G, Hjortnaes Jesper 26 apr 2019, In: Frontiers in cardiovascular medicine. 6

Follistatin-like 1 in Cardiovascular Disease and Inflammation

Peters Marijn M C, Meijs Timion A, Gathier Wouter, Doevendans Pieter A M, Sluijter Joost P G, Chamuleau Steven A J, Neef Klaus 12 mrt 2019, In: Mini-reviews in medicinal chemistry. 19 , p. 1379-1389 11 p.

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology

de Boer Rudolf A, De Keulenaer Gilles, Bauersachs Johann, Brutsaert Dirk, Cleland John G, Diez Javier, Du Xiao-Jun, Ford Paul, Heinzel Frank R, Lipson Kenneth E, McDonagh Theresa, Lopez-Andres Natalia, Lunde Ida G, Lyon Alexander R, Pollesello Piero, Prasad Sanjay K, Tocchetti Carlo G, Mayr Manuel, Sluijter Joost P G, Thum Thomas, Tschöpe Carsten, Zannad Faiez, Zimmermann Wolfram-Hubertus, Ruschitzka Frank, Filippatos Gerasimos, Lindsey Merry L, Maack Christoph, Heymans Stephane 1 mrt 2019, In: European Journal of Heart Failure. 21 , p. 272-285 14 p.

All Research Output (206)
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