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dr. J. (Jorg) van Loosdregt

dr. J. (Jorg) van Loosdregt

Associate Professor

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Research Output (45)

N<sup>6</sup>-Methyladenosine Directly Regulates CD40L Expression in CD4<sup>+</sup> T Lymphocytes

van Vroonhoven Ellen C.N., Picavet Lucas W., Scholman Rianne C., van den Dungen Noortje A.M., Mokry Michal, Evers Anouk, Lebbink Robert J., Calis Jorg J.A., Vastert Sebastiaan J., van Loosdregt Jorg Jul 2023, In: Biology. 12 11 p.

Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation

Mocholi Enric, Russo Laura, Gopal Keshav, Ramstead Andrew G, Hochrein Sophia M, Vos Harmjan R, Geeven Geert, Adegoke Adeolu O, Hoekstra Anna, van Es Robert M, Pittol Jose Ramos, Vastert Sebastian, Rutter Jared, Radstake Timothy, van Loosdregt Jorg, Berkers Celia, Mokry Michal, Anderson Colin C, O'Connell Ryan M, Vaeth Martin, Ussher John, Burgering Boudewijn M T, Coffer Paul J 1 Jun 2023, In: Cell Reports. 42 , p. 1-24

The clinical and experimental treatment of Juvenile Idiopathic Arthritis

Nijhuis L, Swart J F, Prakken B J, V Loosdregt J, Vastert S J 19 Apr 2023, In: Clinical and Experimental Immunology. 213 , p. 276-287 12 p.

Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition

Peeters Janneke G C, Boltjes Arjan, Scholman Rianne C, Vervoort Stephin J, Coffer Paul J, Mokry Michal, Vastert Sebastiaan J, van Wijk Femke, van Loosdregt Jorg 10 Jan 2023, In: Rheumatology (Oxford, England). 62 , p. 2887-2897 11 p.

Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis

Boltjes Arjan, Samat Anoushka Ashok Kumar, Plantinga Maud, Mokry Michal, Castelijns Bas, Swart Joost F., Vastert Sebastiaan J., Creyghton Menno, Nierkens Stefan, van Loosdregt Jorg, van Wijk Femke 4 Jan 2023, In: Frontiers in Immunology. 13

NRF2/Itaconate Axis Regulates Metabolism and Inflammatory Properties of T Cells in Children with JIA

Rajendiran Anandhi, Subramanyam Sudheendra Hebbar, Klemm Patricia, Jankowski Vera, van Loosdregt Jorg, Vastert Bas, Vollbach Kristina, Wagner Norbert, Tenbrock Klaus, Ohl Kim 8 Dec 2022, In: Antioxidants (Basel, Switzerland). 11

Human regulatory T cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

Lutter Lisanne, van der Wal M Marlot, Brand Eelco C, Maschmeyer Patrick, Vastert Sebastiaan, Mashreghi Mir-Farzin, van Loosdregt Jorg, van Wijk Femke 2022, In: Clinical & translational immunology. 11

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

Mijnheer Gerdien, Lutter Lisanne, Mokry Michal, van der Wal Marlot, Scholman Rianne, Fleskens Veerle, Pandit Aridaman, Tao Weiyang, Wekking Mark, Vervoort Stephin, Roberts Ceri, Petrelli Alessandra, Peeters Janneke G C, Knijff Marthe, de Roock Sytze, Vastert Sebastiaan, Taams Leonie S, van Loosdregt Jorg, van Wijk Femke Dec 2021, In: Nature Communications. 12 , p. 1-16

ZFP36 family members regulate the pro-inflammatory features of psoriatic dermal fibroblasts

Angiolilli Chiara, Leijten Emmerik F A, Bekker Cornelis P J, Eeftink Ella, Giovannone Barbara, Nordkamp Michel Olde, van der Wal Marlot, Thijs Judith L, Vastert Sebastiaan J, van Wijk Femke, Radstake Timothy R D J, van Loosdregt Jorg 30 Jul 2021, In: Journal of Investigative Dermatology. 142 , p. 402-413 12 p.

Dutch patients, caregivers and healthcare professionals generate first nationwide research agenda for juvenile idiopathic arthritis

Verwoerd Anouk, Armbrust Wineke, Cowan Katherine, van den Berg Lotte, de Boer Joke, Bookelman Sanne, Britstra Marjan, Cappon Jeannette, Certan Maria, Dedding Christine, van den Haspel Karin, Muller Petra Hissink, Jongsma Karin, Lelieveld Otto, van Loosdregt Jorg, Olsder Wendy, Rocha Johanna, Schatorjé Ellen, Schouten Natasja, Swart Joost F., Vastert Sebastiaan, Walter Margot, Schoemaker Casper G. 7 Apr 2021, In: Pediatric Rheumatology. 19 , p. 1-10

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