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dr. G.J.T. Zwartkruis

Associate Professor

  • CMM Groep Zwartkruis

Research Programs

Research Output (52)

MDH1 deficiency is a metabolic disorder of the malate–aspartate shuttle associated with early onset severe encephalopathy

Broeks Melissa H., Shamseldin Hanan E., Alhashem Amal, Hashem Mais, Abdulwahab Firdous, Alshedi Tarfa, Alobaid Iman, Zwartkruis Fried, Westland Denise, Fuchs Sabine, Verhoeven-Duif Nanda M., Jans Judith J.M., Alkuraya Fowzan S. 19 sep 2019, In: Human Genetics. 138 , p. 1247-1257 11 p.

Discovery of pyridoxal reductase activity as part of human vitamin B6 metabolism

Ramos Rúben J, Albersen Monique, Vringer Esmee, Bosma Marjolein, Zwakenberg Susan, Zwartkruis Fried, Jans Judith J M, Verhoeven-Duif Nanda M jun 2019, In: Biochimica et biophysica acta-General subjects. 1863 , p. 1088-1097 10 p.

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

Rumping Lynne, Tessadori Federico, Pouwels Petra J.W., Vringer Esmee, Wijnen Jannie P., Bhogal Alex A., Savelberg Sanne M.C., Duran Karen J., Bakkers Mark J.G., Ramos Rúben J.J., Schellekens Peter A.W., Kroes Hester Y., Klomp Dennis W.J., Black Graeme C.M., Taylor Rachel L., Bakkers Jeroen P.W., Prinsen Hubertus C.M.T., van der Knaap Marjo S., Dansen Tobias B., Rehmann Holger, Zwartkruis Fried J.T., Houwen Roderick H.J., van Haaften Gijs, Verhoeven-Duif Nanda M., Jans Judith J.M., van Hasselt Peter M. 1 jan 2019, In: Human Molecular Genetics. 28 , p. 96-104 9 p.

Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy

Rumping Lynne, Büttner Benjamin, Maier Oliver, Rehmann Holger, Lequin Maarten, Schlump Jan Ulrich, Schmitt Bernhard, Schiebergen-Bronkhorst Birgit, Prinsen Hubertus C.M.T., Losa Michele, Fingerhut Ralph, Lemke Johannes R., Zwartkruis Fried J.T., Houwen Roderick H.J., Jans Judith J.M., Verhoeven-Duif Nanda M., Van Hasselt Peter M., Jamra Rami 21 dec 2018, In: JAMA Neurology. 76 , p. 342-350 9 p.

Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase

Małecki Je drzej M., Willemen Hanneke L.D.M., Pinto Rita, Ho Angela Y.Y., Moen Anders, Kjønstad Ingrid F., Burgering Boudewijn M.T., Zwartkruis Fried, Eijkelkamp Niels, Falnes Pål 10 dec 2018, In: Journal of Biological Chemistry. 294 , p. 1128-1141 14 p.

A two-tiered mechanism enables localized Cdc42 signaling during enterocyte polarization

Bruurs Lucas J.M., Zwakenberg Susan, van der Net Mirjam C., Zwartkruis Fried J., Bos Johannes L. apr 2017, In: Molecular and Cellular Biology. 37

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization

Bruurs Lucas J M, Donker Lisa, Zwakenberg Susan, Zwartkruis Fried J, Begthel Harry, Knisely A S, Posthuma George, van de Graaf Stan F J, Paulusma Coen C, Bos Johannes L 28 sep 2015, In: Journal of Cell Biology. 210 , p. 1055-63 9 p.

Rheb and Rags come together at the lysosome to activate mTORC1

Groenewoud M.J., Zwartkruis G.J.T. 2013, In: Biochemical Society Transactions. 41 , p. 951-955 5 p.

Rheb and mammalian target of rapamycin in mitochondrial homoeostasis

Groenewoud M.J., Zwartkruis G.J.T. 2013, In: Open Biology. 3 , p. 130185 1 p.

Ras and macropinocytosis: trick and treat

Zwartkruis G.J.T., Burgering B.M.T. 2013, In: Cell Research. 23 , p. 982-983 2 p.

All Research Output (52)