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dr. P. (Petra) de Graaf Assistant Professor

  • Department of Urology

P. de Graaf


Research Programs


Dr. De Graaf studied chemistry with a master in Biochemistry at Utrecht University (UU). Her PhD was performed at the faculty of biology (UU) in the laboratory of Prof. Arie Verkleij and Dr. Paul van Bergen en Henegouwen on lipid kinases. After a short postdoc in the LUMC Leiden, she returned to Utrecht for an extended postdoc in the lab of Prof. Marc Timmers. Here she introduced microscopy as a tool to study basic transcription regulation. Since 2014 she works in the department of Urology.

Her current research goal is to generate a tissue engineered (TE) source of urethra tissue for use in urethral reconstruction. Ideally, a TE urethra mimics the native urethra, consists of multiple cell layers of different origin, protects the underlying tissue as an efficient barrier from urine, is vascularized and resistant to mechanical forces during surgery. As in many patients undergoing urethral reconstruction surgery, the surrounding corpus spongiosum is either absent (in hypospadias patients) or affected by fibrosis, we aim to integrate the corpus spongiosum in our TE graft, providing the natural vascular environment. The molecular background helps to bring the science to life: experience and knowledge acquired through the years will lead to solutions for health and disease.

Research Output (27)

Correction for Danovi et al., "Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity".

Danovi Davide, Meulmeester Erik, Pasini Diego, Migliorini Domenico, Capra Maria, Frenk Ruth, de Graaf Petra, Francoz Sarah, Gasparini Patrizia, Gobbi Alberto, Helin Kristian, Pelicci Pier Giuseppe, Jochemsen Aart G., Marine Jean Christophe 1 aug 2019, In: Molecular and Cellular Biology. 39

Scaffolds for reconstruction of penile corporal tissue

Tsachouridis G, de Kemp Vincent, de Kort Laetitia, de Graaf Petra 21 jun 2019, volume 2

Genomic integrity of ground-state pluripotency

Jafari Narges, Giehr Pascal, Hesaraki Mahdi, Baas Roy, de Graaf Petra, Timmers H. T.Marc, Walter Jörn, Baharvand Hossein, Totonchi Mehdi dec 2018, In: Journal of Cellular Biochemistry. 119 , p. 9781-9789

Biomechanical Properties of the Pelvic Floor and its Relation to Pelvic Floor Disorders

Ruiz-Zapata Alejandra M., Feola Andrew J., Heesakkers John, de Graaf Petra, Blaganje Mija, Sievert Karl Dietrich 1 apr 2018, In: European Urology, Supplements. 17 , p. 80-90 11 p.

Systematic Review to Compare Urothelium Differentiation with Urethral Epithelium Differentiation in Fetal Development, as a Basis for Tissue Engineering of the Male Urethra

de Graaf Petra, van der Linde E Martine, Rosier Peter F W M, Izeta Ander, Sievert Karl Dietrich, Bosch J L H Ruud, de Kort Laetitia M O jun 2017, In: Tissue engineering. Part B. Reviews. 23 , p. 257-267 11 p.

Architectuur van het corpus spongiosum:een anatomische studie

Ottenhof Sarah R., de Graaf Petra, Soeterik Timo F.W., Neeter Lidewij M.F.H., Zilverschoon Marijn, Spinder Matty, Bosch J. L.H.Ruud, Bleys Ronald L.A.W., de Kort Laetitia M.O. nov 2016, In: Tijdschrift voor Urologie. 7 , p. 178-187 10 p.

Architecture of the Corpus Spongiosum:An Anatomical Study

Ottenhof Sarah R, de Graaf Petra, Soeterik Timo F W, Neeter Lidewij M F H, Zilverschoon Marijn, Spinder Matty, Bosch J L H Ruud, Bleys Ronald L A W, Heck-de Kort Laetitia sep 2016, In: The Journal of Urology. 196 , p. 919-925 7 p.

Tissue Engineering for Human Urethral Reconstruction:Systematic Review of Recent Literature

de Kemp Vincent, de Graaf Petra, Fledderus Joost O. , Bosch JLHR, de Kort Laetitia 17 feb 2015, In: PLoS ONE [E]. 10 14 p.

A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels

Baas R., Lelieveld D., van Teeffelen H.A.A.M., Lijnzaad P., Castelijns B., van Schaik F.M.A., Vermeulen M., Egan D.A., Timmers H.T.M., de Graaf P. 2014, In: Journal of biomolecular screening. 19 , p. 287-296 10 p.

Balancing of histone H3K4 methylation states by the Kdm5c/SMCX histone demethylase modulates promoter and enhancer function

Outchkourov N.S., Muino J.M., Kaufmann K., van IJcken W., Groot Koerkamp M.J.A., van Leenen D., de Graaf P., Holstege F.C.P., Grosveld F.G., Timmers H.T.M. 2013, In: Cell Reports [E]. 3 , p. 1071-1079 9 p.

All Research Output (27)
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