Terug
Fludarabine (English)
Fludarabine (English)
Bepaling
Fludarabine (English)
| Synonyms: | Fludara |
| Sampling tube | EDTA/2 mL (without gel!) |
| Volume: | Minimal: 0,5 ml plasma |
| Administation and Sampling: | For sampling we refer tot the busulfan protocol. Fludarabine concentrations are measured ursing samples collected for busulfan TDM. Click the link below to download the full Dosing, Administrating and Sampling protocol of Busulfan at the UMC Utrecht. Busulfan English |
| Verzendcondities: | Send the plasma samples on dry ice via overnight delivery to the UMC Utrecht pharmacology lab (see Address) |
| Storage conditions: | Plasma; -20 °C |
| Method: | LC-MS/MS |
| Frequency: | On request |
| Form: | Please fill out our digital form - Click here |
| Address: | Please copy this exact Dutch text: UMC Utrecht CDL lokatie G.03.330 Materiaal t.a.v. Laboratorium Apotheek Heidelberglaan 100 3584 CX Utrecht Nederland |
| Contacts: | Kim van der Elst, clinical pharmacist |
| AUC Target: | 15-25 mg*h/L |
| Clinical background: | Fludarabine is the most frequently used agent in conditioning regimens for allogeneic hematopoietic cell transplantation Optimal fludarabine exposure has been associated with improved treatment outcome in allogeneic hematopoietic cell transplantation, suggesting potential benefit of individualized dosing. The cumulative target area under the concentration curve (AUC) that we recommend for both adults and children is 20 mg*h/L (range 17.5-22.5 mg*h/L) [1]. For children who receive fludarabine prior to CAR T-cell infusion, we recommend a cumulative target AUC of 14-18 mg*h/L [2]. |
| References: | [1] Langenhorst et al. Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes. Blood Adv. 2019 Jul 23;3(14):2179-2187 [2] Dekker et al. Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia. Blood Adv. 2022;6(7):1969-1976. |
| Last check: | 27/03/2023 |
| Quality system: | ISO 15189 (M219), KF.TDM.02 |