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H.T.M. Timmers

Hoogleraar Epigenetica en Gen Regulatie

Afdelingen / poliklinieken

Molecular Cancer Research

Wetenschappelijk onderzoek

The research focus is to understand the molecular mechanisms of the interplay between chromatin modifications (in particular: histone methylation) and basal transcription factors like TFIID.
We employ and maintain “state-of-the-art” proteomics and genomics technologies to study the dynamics and genome localization of transcription factor complexes upon internal and external cues.


  • March, 1990 Ph.D. with Prof.dr. A.J. van der Eb, Faculty of Medicine, University of Leiden, The Netherlands
  • Post-doctoral training in laboratory of Prof. P.A. Sharp, Centerfor Cancer Research, M.I.T., Cambridge, U.S.A
  • Assistant Professor at the Laboratory for Physiological Chemistry, Utrecht University, The Netherlands
  • 1996-2000 : Associate Professor at the Laboratory for Physiological Chemistry, Utrecht University, The Netherlands
  • 2001- now: Full Professor Molecular Biology at the Laboratory for Physiological Chemistry, UMCU, The Netherlands


  • Folkert J. van Werven, Harm van Bakel, Hetty van Teeffelen,Maarten Altelaar, Marian Groot Koerkamp, Albert J.R. Heck, Frank C.P. Holstege, H.Th.Marc Timmers (2008) Cooperativeaction of NC2 and Mot1p to regulate TATA-binding protein function across the genome. Genes Dev. 22, 2359-2369.
  • Michiel Vermeulen, Klaas W. Mulder, Sergei Denissov,W.W.M.Pim Pijnappel, Frederik M.A. van Schaik, Radhika A.Warrier, Marijke P.A. Baltissen, Henk G. Stunnenberg, Matthias Mann and H.Th.Marc Timmers (2007) Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine four. Cell 131, 58-69.
  • G.Sebastiaan Winkler, Klaas W. Mulder, Vivian J. Bardwell, Eric Kalkhoven and H.Th.Marc Timmers (2006) Human Ccr4-Notcomplex is a ligand-dependent repressor of nuclear receptor-mediated transcription. EMBO J. 25, 3089-3099.
  • Koen M.A. Dreijerink, Klaas W. Mulder, G. Sebastiaan Winkler,Jo W.M. Hoppener, Cornelis J.M. Lips and H.Th.Marc Timmers(2006) Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer Research 66, 4929-4935
  • Jan A. van der Knaap, J.W. Borst, Peter C. van der Vliet, R.Gentz and H.Th.Marc Timmers (1997) Cloning of the cDNA for the TATA-binding protein-associated factor (II)170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila. Proc. Natl.Acad. Sci. USA 94, 11827-11832.

Persoonlijke prijzen, subsidies en onderscheidingen

  • Theme leader “NPCII: Proteome Biology of Stem cells” (2009-2012).
  • Member of the Editorial Board of the Journal of Biological Chemistry (2009-2014)


  • Reviewer for articles
  • Panel member for national and international grant evaluations
  • Scientific evaluation committee international institutes
  • Member of board NVBMB (1998-2006)
  • Member redactieraad C2W (2006-now)
  • Member study section Nucleic Acids (2004-2007)