Infection and Immunity nieuws
Infection and Immunity nieuws
Jun 7: A critical appraisal of clinical decision support systems for immune diseases
This PhD thesis by Marianne Messelink (UMC Utrecht) describes the development, validation and evaluation of clinical decision support systems for rheumatoid arthritis and primary antibody deficiency. Such systems have the potential to advance diagnoses and optimize treatments. However, there are also challenges and pitfalls in their development and implementation. Ultimately, the focus should not be on the predictive value, but on the real benefit to the patient and healthcare system.
Read moreJun 6: Lymphocyte dynamics in a more natural mouse model
Lymphocyte dynamics research by Elena de Dios Panal (UMC Utrecht) shows that animal models provided valuable information that could hardly or not at all be obtained from humans. However, the discrepancies between human and murine immune dynamics found in parts of this thesis highlight some fundamental differences between murine and human immune cell maintenance. While animal models still hold potential, their critical discussion remains crucial.
Read morePatricia Bruijning-Verhagen appointed professor of vaccination and infection control epidemiology
Utrecht University and UMC Utrecht have announced the appointment of Patricia Bruijning-Verhagen as professor of vaccination and infection control epidemiology, effective June 1, 2024. This position will enable Patricia to continue her work in designing and evaluating optimal infection prevention policies through vaccination and other innovative strategies. Her appointment comes at a crucial time, as the world faces the dual challenge of emerging infectious diseases and an expanding portfolio of vaccines.
Read moreJune 3: Life span of lymphocytes further unraveled
In her PhD thesis, Carina Bruckmaier (UMC Utrecht) explored lymphocyte dynamics in various tissue sites in homeostasis and during imbalanced states. In particular, her research on the life span of some of the lymphocyte subcategories revealed some interesting new insights.
Read moreMay 29: Unveiling the mysteries of smell: research on COVID-19-related smell loss
During the COVID-19 pandemic – especially during the first wave of infections- a large number of people infected with the SARS-CoV-2 virus reported a sudden loss of smell. Dutch investigators quickly set up a series of studies on diagnosis, pathophysiology, epidemiology, clinical course and treatment of COVID-19-induced loss of smell. The PhD thesis by Emma Schepens (UMC Utrecht) provides some interesting and valuable insights on this unexpected clinical finding.
Read moreMay 27: New research provides further evidence that pediatric uveitis is a systemic immune disease
Pediatric uveitis might be a manifestation of a disease that affects not only the eye but also the systemic immune system and microcirculation. Therefore, it is important to adopt a multidisciplinary approach in the management of pediatric uveitis patients to provide the best possible care. These were the main takeaways from the PhD research by Carlyn Kouwenberg from UMC Utrecht.
Read moreAlternatives to antibiotics: Adapting phages to overcome bacterial defense barriers
Collaborating researchers from University Medical Center Utrecht and Delft University of Technology have received funding from the Dutch Research Council (NWO) to develop more broadly acting bacteriophages. With help of such adapted phages, the researchers want to overcome bacterial defense barriers, which are important mechanisms in the bacterial resistance against bacteriophages.
Read moreStudy of new treatment for severe influenza pneumonia
Van elke vijf patiënten die met ernstige longontsteking door influenza op de intensive care (IC) worden opgenomen, overlijdt er gemiddeld één. Om dit relatief hoge risico op overlijden te verlagen, gaan Nederlandse onderzoekers onder leiding van UMC Utrecht geneesmiddelen die eerder succesvol waren bij de behandeling van patiënten met ernstige Covid-19 op de IC terecht kwamen, nu ook onderzoeken bij IC-patiënten met ernstige longontsteking door influenza. ZonMw heeft voor deze studie een subsidie van ruim € 2.1 miljoen beschikbaar gesteld.
Read moreApr 23: Existing drugs now available in study for patients with rare immune diseases
This DRIMID study will investigate the efficacy and safety of the drug filgotinib (approved for treatment of rheumatoid arthritis and ulcerative colitis) in three rare immune diseases (Behçet's disease, idiopathic inflammatory myositis, IgG4-related disease)
Read moreApr 15: "The Next Step" - Jeanette Leusen's inaugural lecture
On Tuesday, April 9, 2024, Jeanette Leusen, professor of Antibody Therapy at Utrecht University and UMC Utrecht, delivered her inaugural lecture. There she addressed the discovery, development and clinical application of antibodies. Partly due to the research of Jeanette and her group, antibodies based on immunoglobulin A (IgA) also appear to have great potential as a next generation treatment option in cancer, and perhaps also in infectious diseases. A first drug candidate is now ready for the next step: a ‘first-in-human’ study, but this will require more investment.
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