prof. dr. P.J. (Paul) CofferFull Professor
- Stem Cells
Paul Coffer studied Biochemistry at Oxford University and obtained his PhD from the Ludwig Institute for Cancer Research in London, UK where he identified Protein Kinase B (PKB/AKT), a critical intracellular hub regulating multiple cellular processes.
He then relocated to the Hubrecht Laboratory for Developmental Biology and Stem Cell Research. This postdoctoral research was involved in investigating the mechanisms by which hematopoietic cytokines can regulate gene expression through transcription factor phosphorylation.
Paul moved to the Department of Respiratory Medicine at the University Medical Centre Utrecht to initiate his own research group. During this period, work involved studying the role of intracellular signal transduction pathways in regulating both the production and function of leukocytes. Work in his group also demonstrated that PKB-mediated phosphorylation of Forkhead transcription factors (FOXO) was critical for the regulation of leukocyte proliferation and survival. These studies laid the groundwork for his further research into the regulation of hematopoietic stem cell-fate decisions.
In 2005 Paul Coffer was appointed Professor of Pediatric Immunology moving to the Wilhelmina Children's Hospital (UMCU). During this time research was expanded to investigate the molecular mechanisms regulating mesenchymal stem stem cell (MSC) function and generation of induced pluripotent stem cells (iPSC) as models of disease. Furthermore, studies investigating the molecular mechanisms underlying T-regulatory cell function were initiated.
In 2010 he was appointed Professor of Stem Cell Biology and currently works at the Department of Cell Biology in close collaboration with the Division of Pediatrics. Current work is focussed on themes of stem cells, immunology and cancer. He has recently returned from a year sabbatical at Memorial Sloan-Kettering Cancer Center (New York) working in the Rudensky Lab.
2019- Board of trustees, World Wide Cancer Research
2016-Study Section member for both Fundamental and Translational applications for the Dutch Rheumatology Foundation (ReumaFonds; around 100 grant applications per year)
2016/2018 Study section member for the Swedish Research Council (SRC), consolidator grants for established investigators.
2016 Study section member for National Institutes of Health (NIH/NIAD), Immunology review branch.
2016 Advisory panel member and site visit for quinquennial review of Molecular Mechanisms of Disease Master’s program, Radboud University (Nijmegen, The Netherlands)
2014- Hubrecht Institute selection committee for new junior and senior principle investigators
2013-2018 Study section member for the Worldwide Cancer Research (WWCR/AICR; more than 800 international grant applications submitted each year)
2011/2014 Scientific Advisory Board Member and site visit, ViB Institute of Inflammation & Immunity (Ghent, Belgium).
2008- Committee member Dutch Society for Stem Cell Research (DSSCR) and chair 2010 & 2015
2011-2012 Study section member for Netherlands Organization for Scientific Research (NWO) collaborative TOP grants for senior PIs and largest national project grant applications
2008 Site visit for Leukemia Research Foundation UK (Immunodiagnostics Unit, John Radcliff Hospital, Oxford)
2007 Study section member Portugese Foundation of Science & Technology (FCT)
2005- Section Editor, Journal of Leukocyte Biology
Regular reviewer for journals: Nature, Science, Science Immunology, Nature Cell Biology, Nature Immunology, Nature Communications, Immunity, Journal of Clinical Investigation, Journal of Experimental Medicine, EMBO Journal, Blood, Oncogene, Molecular Cell Biology, Journal of Biological Chemistry, Journal of Immunology.
Ad hoc reviewer of grants for: National Institutes of Health (NIH), Dutch Scientific Organisation (NWO), Dutch Cancer Foundation (KWF), Swedish Research Council (SRC); Cancer Research UK (CRUK), Wellcome Trust UK, BBRC UK, Leukemia Research Foundation (LRF), Swiss National Science Foundation (SNF), Portugese Foundation of Science & Technology (FCT).
Research Output (180)
Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development
Govers Anita M A P, Wiggers Caroline R M, van Boxtel Ruben, Mokry Michal, Nieuwenhuis Edward E S, Creyghton Menno P, Bartels Marije, Coffer Paul J aug 2019, In: HemaSphere. 3
Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia
Wiggers Caroline R M, Govers Anita M A P, Lelieveld Daphne, Egan David A, Zwaan C Michel, Sonneveld Edwin, Coffer Paul J, Bartels Marije 1 mei 2019, In: Pediatric Blood & Cancer. 66
Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells
Fleskens Veerle, Minutti Carlos M., Wu Xingmei, Wei Ping, Pals Cornelieke E.G.M., McCrae James, Hemmers Saskia, Groenewold Vincent, Vos Harm Jan, Rudensky Alexander, Pan Fan, Li Huabin, Zaiss Dietmar M., Coffer Paul J. 26 mrt 2019, In: Cell Reports. 26 , p. 3600-3612.e6
Vervoort Stephin J, de Jong Olivier G, Roukens M Guy, Frederiks Cynthia L, Vermeulen Jeroen F, Lourenço Ana Rita, Bella Laura, Vidakovic Ana Tufegdzic, Sandoval José L, Moelans Cathy, van Amersfoort Miranda, Dallman Margaret J, Bruna Alejandra, Caldas Carlos, Nieuwenhuis Edward, van der Wall Elsken, Derksen Patrick, van Diest Paul, Verhaar Marianne C, Lam Eric W-F, Mokry Michal, Coffer Paul J 3 dec 2018, In: eLife. 7
SOX4 inhibits oligodendrocyte differentiation of embryonic neural stem cells in vitro by inducing Hes5 expression
Braccioli Luca, Vervoort Stephin J., Puma Gianmarco, Nijboer Cora H., Coffer Paul J. 1 dec 2018, In: Stem Cell Research. 33 , p. 110-119 10 p.
Van Loosdregt Jorg, Coffer Paul J. 15 okt 2018, In: Journal of Immunology. 201 , p. 2193-2200 8 p.
SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis
Vervoort Stephin J., Lourenço Ana Rita, Tufegdzic Vidakovic Ana, Mocholi Enric, Sandoval José L., Rueda Oscar M., Frederiks Cynthia, Pals Cornelieke, Peeters Janneke G.C., Caldas Carlos, Bruna Alejandra, Coffer Paul J. 12 okt 2018, In: Nucleic Acids Research. 46 , p. 9578-9590 13 p.
PD-1<sup>+</sup>CD8<sup>+</sup> T cells are clonally expanding effectors in human chronic inflammation
Petrelli Alessandra, Mijnheer Gerdien, Hoytema Van Konijnenburg David P., Van Der Wal Maria M., Giovannone Barbara, Mocholi Enric, Vazirpanah Nadia, Broen Jasper C., Hijnen Dirkjan, Oldenburg Bas, Coffer Paul J., Vastert Sebastian J., Prakken Berent J., Spierings Eric, Pandit Aridaman, Mokry Michal, Van Wijk Femke 1 okt 2018, In: Journal of Clinical Investigation. 128 , p. 4669-4681 13 p.
STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells
Ribeiro Daniel, Melão Alice, van Boxtel Ruben, Santos Cristina I, Silva Ana, Silva Milene C, Cardoso Bruno A, Coffer Paul J, Barata João T 11 sep 2018, In: Blood Advances. 2 , p. 2199-2213 15 p.
Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy
Peeters J. G.C., Picavet L. W., Coenen S. G.J.M., Mauthe M., Vervoort S. J., Mocholi E., de Heus C., Klumperman J., Vastert S. J., Reggiori F., Coffer P. J., Mokry M., van Loosdregt J. 28 aug 2018, In: Autophagy. 15 , p. 98-112 15 p.