dr. M.I. (Mirjam) Geerlings

Associate Professor

  • Department of Epidemiology
  • Julius Center Research Program Cardiovascular Epidemiology

dr. M.I. (Mirjam) Geerlings

Research Programs


Mirjam Geerlings received her MSc degree in Neuropsychology (1994) and her PhD degree in Epidemiology (2000) from the VU medical center Amsterdam, the Netherlands, both of which were awarded for the best thesis. From 2000 until 2002 she worked as a post-doc at the Erasmus Medical Center, Rotterdam (Dept Epidemiology & Biostatistics) where she studied steroid hormones as risk factors for dementia using data from the Rotterdam Study. Since 2002, she works at the University Medical Center Utrecht (Julius Center for Health Sciences and Primary Care). In 2006, she obtained an Innovational Research Incentives (VIDI) grant and ASPASIA grant to study depression and stress hormones as risk factors for hippocampal atrophy and Alzheimer disease and was appointed Associate Professor Neuro-epidemiology. In 2006 (Apr-Sep), she worked at the Sergievsky Center of Columbia University, New York (S Small and R Mayeux). From Oct 2011 to Oct 2012 she worked at the National Institute on Aging, Lab of Epidemiology, Demography, and Biometry (chief Dr LJ Launer), Bethesda, Md, USA. In 2012, she was nominated for AcademiaNet, a database of excellent female reserachers. Since 2014, she is leader of the theme ‘Brain’, one of the 3 strategic themes of the Cardiovascular Epidemiology programme of the Julius Center.

Research line

Epidemiology of the aging brain

Most recent key publications

Geerlings MI & Gerritsen L. Late-life Depression, Hippocampal Volumes, and Hypothalamic-Pituitary-Adrenal Axis Regulation: A Systematic Review and Meta-analysis. Biol Psychiatry 2017, Jan 27 [epub ahead of print]. PMID: 28318491

Buddeke J, Kooistra M, Zuithoff NP, Gerritsen L, Biessels GJ, van der Graaf Y, Geerlings MI; SMART Study Group. Hippocampal volume and the course of depressive symptoms over eight years of follow-up. Acta Psychiatr Scand 2017;135:78-85.[2016 Nov 1 Epub ahead of print]. PMID: 27800603

Ghaznawi R, de Bresser J, van der Graaf Y, Zwartbol MH, Witkamp TD, Geerlings MI, Hendrikse J; SMART Study Group. Detection and characterization of small infarcts in the caudate nucleus on 7 tesla MRI: The SMART-MR study. J Cereb Blood Flow Metab 2017; Jan 1 [Epub ahead of print].

Wisse LEM, Kuijf HJ, Honingh AM, Wang H, Pluta JB, Das SR, Wolk DA, Zwanenburg JJM, Yushkevich PA, Geerlings, MI. Automated hippocampal subfield segmentation at 7 tesla MRI. AJNR Am J Neuroradiol 2016;37:1050-1057. PMID: 26846925

Kooistra M, van der Graaf Y, Grool AM, Zuithoff NP, Biessels GJ, Geerlings MI. The natural course of elevated levels of depressive symptoms in patients with vascular disease over eight years of follow-up. The SMART-Medea study. J Affect Disord 2016;202:95-101. PMID: 27259081

Geerlings MI, Sigurdsson S, Eiriksdottir G, Garcia ME, Harris TB, Gudnason V, Launer LJ. Salivary cortisol, brain volumes, and cognition in community-dwelling elderly without dementia. Neurology 2015;85:976-83. PMID: 26291281

Gerritsen L, van Velzen L, Schmaal L, van der Graaf Y, van der Wee N, van Tol MJ, Penninx B, Geerlings M. Childhood maltreatment modifies the relationship of depression with hippocampal volume. Psychol Med 2015;45:3517-3526. PMID: 26204801

Wisse LE, Biessels GJ, Stegenga BT, Kooistra M, van der Veen PH, Zwanenburg JJ, van der Graaf Y, Geerlings MI. Major depressive episodes over the course of 7 years and hippocampal subfield volumes at 7 tesla MRI: the PREDICT-MR study. J Affect Disord 2015;175:1-7. PMID: 25589378

Jochemsen HM, Muller M, Bots ML, Scheltens Ph, Vincken KL, Mali WPTM, van der Graaf Y, Geerlings MI. Arterial stiffness and progression of structural brain changes. The SMART-MR study. Neurology 2015;84:448-455. PMID: 25552578

Kooistra M, Zuithoff NP, Grool AM, Zinsmeester M, Biessels GJ, van der Graaf Y, Geerlings MI. Cognitive performance and the course of depressive symptoms over 7 years of follow-up: The SMART-MR Study. Psychol Med 2015;45:1741-1750. PMID: 25499398

van der Veen PH, Muller M, Vincken KL, Hendrikse J, Mali WP, van der Graaf Y, Geerlings MI; SMART Study Group. Longitudinal relationship between cerebral small-vessel disease and cerebral blood flow: the second manifestations of arterial disease-magnetic resonance study. Stroke 2015;46:1233-1238. PMID: 25804924

De Cocker LJ, Kloppenborg RP, van der Graaf Y, Luijten PR, Hendrikse J, Geerlings MI; SMART Study Group. Cerebellar Cortical Infarct Cavities: Correlation With Risk Factors and MRI Markers of Cerebrovascular Disease. Stroke 2015;46:3154-3160. PMID:26382175. Correction in: Stroke 2016;47:e38. PMID: 26811333

Wisse LEM, Biessels GJ, Heringa SM, Kuijf HJ, Koek HL, Luijten PR, Geerlings MI. Hippocampal subfield volumes at 7T in early Alzheimer disease and normal aging. Neurobiol Aging 2014;35:2039-2045. PMID: 24684788

Geerlings MI, Sigurdsson S, Eiriksdottir G, Garcia ME, Harris TB, Sigurdsson T, Gudnason V, Launer LJ. Associations of current and remitted major depressive disorder with brain atrohpy: the AGES-Reykjavik Study. Psychol Med 2013;43:317-28. PMID: 22647536

Geerlings MI, Brickman AM, Schupf N, Devanand DP, Luchsinger JA, Mayeux R, Small SA. Depressive symptoms, antidepressant use, and brain volumes on MRI in a population-based cohort of old persons without dementia. J Alzheimers Dis 2012;30:75-82. PIMD 22377782

Fellowship and Awards

  • VIDI (2005)
    ASPASIA (2006)
    University Medical Center Utrecht, Program Internationalisation Research (2006)
    University Medical Center Utrecht, Program Internationalisation Research (2010)
    Prize for the best PhD thesis of the research school CARE (2000)

Research Output (205)


Zwartbol M H T, van der Kolk A G, Geerlings M I 30 apr 2020, In: AJNR. American journal of neuroradiology. 41

Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer's disease:A 7 Tesla MRI study

Bouvy Willem H, van Veluw Susanne J, Kuijf Hugo J, Zwanenburg Jaco Jm, Kappelle Jaap L, Luijten Peter R, Koek Huiberdina L, Geerlings Mirjam I, Biessels Geert J, apr 2020, In: Journal of Cerebral Blood Flow and Metabolism. 40 , p. 739-746 8 p.

Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis:The SMART-MR Study

Zwartbol M. H. T., Geerlings M. I., Ghaznawi R., Hendrikse J., van der Kolk A. G., Asselbergs F. W., Nathoe H. M., de Borst G. J., Bots M. L., Emmelot M. H., de Jong P. A., Leiner T., Lely A. T., van der Kaaij N. P., Kappelle L. J., Ruigrok Y. M., Verhaar M. C., Visseren F. L. J., Westerink J., 5 dec 2019, In: American Journal of Neuroradiology. 40 , p. 2016-2022 7 p.

Progress update from the hippocampal subfields group

Olsen Rosanna K, Carr Valerie A, Daugherty Ana M, La Joie Renaud, Amaral Robert S C, Amunts Katrin, Augustinack Jean C, Bakker Arnold, Bender Andrew R, Berron David, Boccardi Marina, Bocchetta Martina, Burggren Alison C, Chakravarty M Mallar, Chételat Gaël, de Flores Robin, DeKraker Jordan, Ding Song-Lin, Geerlings Mirjam I, Huang Yushan, Insausti Ricardo, Johnson Elliott G, Kanel Prabesh, Kedo Olga, Kennedy Kristen M, Keresztes Attila, Lee Joshua K, Lindenberger Ulman, Mueller Susanne G, Mulligan Elizabeth M, Ofen Noa, Palombo Daniela J, Pasquini Lorenzo, Pluta John, Raz Naftali, Rodrigue Karen M, Schlichting Margaret L, Lee Shing Yee, Stark Craig E L, Steve Trevor A, Suthana Nanthia A, Wang Lei, Werkle-Bergner Markus, Yushkevich Paul A, Yu Qijing, Wisse Laura E M, 1 dec 2019, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11 , p. 439-449 11 p.

Risk factors of mortality in older patients with dementia in psychiatric care

Goluke Nienke M S, Geerlings Mirjam I, van de Vorst Irene E, Vaartjes Ilonca H, de Jonghe Annemarieke, Bots Michiel L, Koek Huiberdina L 10 nov 2019, In: International Journal of Geriatric Psychiatry. 35 , p. 174-181 8 p.

Risk factors for in-hospital mortality in patients with dementia

Golüke Nienke M S, van de Vorst Irene E, Vaartjes Ilonca H, Geerlings Mirjam I, de Jonghe Annemarieke, Bots Michiel L, Koek Huiberdina L nov 2019, In: Maturitas. 129 , p. 57-61 5 p.

Hippocampal sulcal cavities prevalence, risk factors and association with cognitive performance. The SMART-Medea study and PREDICT-MR study

Blom Kim, Koek Huiberdina L, van der Graaf Yolanda, Zwartbol Maarten H T, Wisse Laura E M, Hendrikse Jeroen, Biessels Geert Jan, Geerlings Mirjam I, aug 2019, In: Brain Imaging and Behavior. 13 , p. 1093-1102 10 p.

Subjective cognitive decline, brain imaging biomarkers, and cognitive functioning in patients with a history of vascular disease:the SMART-Medea study

Blom Kim, Koek Huiberdina L, Zwartbol Maarten H T, van der Graaf Yolanda, Kesseler Lara, Biessels Geert Jan, Geerlings Mirjam I, 24 jul 2019, In: Neurobiology of Aging. 84 , p. 33-40 8 p.

The effect of computerized decision support systems on cardiovascular risk factors:A systematic review and meta-analysis

Groenhof T. Katrien J., Asselbergs Folkert W., Groenwold Rolf H. H., Grobbee Diederick E., Visseren Frank L. J., Bots Michiel L., Asselbergs Folkert W., Nathoe H. M., de Borst G. J., Bots Michiel L., Geerlings M. I., Emmelot M. H., de Jong P. A., Leiner T., Lely A. T., van der Kaaij N. P., Kappelle L. J., Ruigrok Y. M., Verhaar M. C., Visseren Frank L. J., Westerink J. 10 jun 2019, In: BMC Medical Informatics and Decision Making. 19 , p. 108

Effect of physical exercise on cognitive function and brain measures after chemotherapy in patients with breast cancer (PAM study):protocol of a randomised controlled trial

Witlox Lenja, Schagen Sanne B, de Ruiter Michiel B, Geerlings Mirjam I, Peeters Petra H M, Koevoets Emmie W, van der Wall Elsken, Stuiver Martijn, Sonke Gabe, Velthuis Miranda J, Palen Job A M van der, Jobsen Jan J, May Anne M, Monninkhof E M 1 jun 2019, In: BMJ Open. 9

All Research Output (205)