dr. C.A. (Caroline) Lindemans

Assistant Professor - medical

  • SCT patient care

dr. C.A. (Caroline) Lindemans


Caroline Lindemans, MD, PhD is a pediatrician, BMT specialist  and pediatric immunologist in the UMC Utrecht. Appointed as a consultant in HCT she has a special  research interest in graft versus host disease, intestinal toxicity, it’s prevention and therapy.  After receiving a KWF fellowship grant she recently worked at Memorial Sloan Kettering Cancer Center in the Research groups of Marcel van den Brink  and Alan Hanash resulting in a first author Nature paper, published December 2015. She has ongoing collaborations with these groups and is currently expanding this line of research in the UMC Utrecht.  Caroline is an active member of various international working committees (e.g. EBMT, CIBMTR: chair of one of the CIBMTR working committees).

Side Activities

    • Co-chair CIBMTR working committee Infection and Immunity February 2014—Feb 2017
    • Medical Consultant Chimerix europe (Brincidofovir studies): 2015-heden

Fellowship and Awards

    • 2000 Wilhelmina Children's Hospital Student Research Prize
    • 2010 ASBMT Travel grant for young investigators $500
    • 2012 Abstract award winner international cord blood symposium
    • 2012 UMC Utrecht mobilization grant  €20.000 euro
    • 2013 Wilhelmina Children’s hospital Fund: Leading ladies  research stimulation grant €125.000 euro
    • 2013 Travel Stipendium Nijbakker Morra Foundation €9.600 euro
    • 2013 KWF (Dutch Cancer Society) Clinical fellowship Grant €250.000 euro. To study tissue regeneratation in GVHD.
    • 2014 ASH Abstract Achievement Award

Research Output (66)

Metachromatic leukodystrophy and transplantation:remyelination, no cross-correction

Wolf Nicole I., Breur Marjolein, Plug Bonnie, Beerepoot Shanice, Westerveld Aimee S.R., van Rappard Diane F., de Vries Sharon I., Kole Maarten H.P., Vanderver Adeline, van der Knaap Marjo S., Lindemans Caroline A., van Hasselt Peter M., Boelens Jaap J., Matzner Ulrich, Gieselmann Volkmar, Bugiani Marianna 22 jan 2020, In: Annals of Clinical and Translational Neurology. 7 , p. 169-180 12 p.

T cell-derived interferon-gamma programs stem cell death in immune-mediated intestinal damage

Takashima S., Martin M. L., Jansen S. A., Fu Y., Bos J., Chandra D., O'Connor M. H., Mertelsmann A. M., Vinci P., Kuttiyara J., Devlin S. M., Middendorp S., Calafiore M., Egorova A., Kleppe M., Lo Y., Shroyer N. F., Cheng E. H., Levine R. L., Liu C., Kolesnick R., Lindemans C. A., Hanash A. M. 6 dec 2019, In: Science Immunology. 4

Peripheral neuropathy in metachromatic leukodystrophy: current status and future perspective

Beerepoot Shanice, Nierkens Stefan, Boelens Jaap-Jan, Lindemans Caroline, Bugiani Marianna, Wolf Nicole I. 4 nov 2019, In: Orphanet Journal of Rare Diseases. 14

Bloodstream Infection Due to Vancomycin-resistant Enterococcus Is Associated With Increased Mortality After Hematopoietic Cell Transplantation for Acute Leukemia and Myelodysplastic Syndrome:A Multicenter, Retrospective Cohort Study

Papanicolaou Genovefa A., Ustun Celalettin, Young Jo Anne H., Chen Min, Kim Soyoung, Woo Ahn Kwang, Komanduri Krishna, Lindemans Caroline, Auletta Jeffery J., Riches Marcie L., 30 okt 2019, In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 69 , p. 1771-1779 9 p.

Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1

Ustun Celalettin, Kim Soyoung, Chen Min, Beitinjaneh Amer M., Brown Valerie I., Dahi Parastoo B., Daly Andrew, Diaz Miguel Angel, Freytes Cesar O., Ganguly Siddhartha, Hashmi Shahrukh, Hildebrandt Gerhard C., Lazarus Hillard M., Nishihori Taiga, Olsson Richard F., Page Kristin M., Papanicolaou Genovefa, Saad Ayman, Seo Sachiko, William Basem M., Wingard John R., Wirk Baldeep, Yared Jean A., Perales Miguel Angel, Auletta Jeffery J., Komanduri Krishna V., Lindemans Caroline A., Riches Marcie L. 10 sep 2019, In: Blood Advances. 3 , p. 2525-2536 12 p.

Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes:a CIBMTR contemporary longitudinal study

Abidi Maheen Z., Hari Parameswaran, Chen Min, Kim Soyoung, Battiwala Minoo, Dahi Parastoo Bahrami, Diaz Miguel Angel, Gale Robert Peter, Ganguly Siddhartha, Gergis Usama, Green Jaime, Hildebrandt Gerhard, Hill Joshua A., Komanduri Krishna, Lazarus Hillard, Marks David, Nishihori Taiga, Olsson Richard, Seo Sachiko, Ustun Celalettin, Yared Jean, Yin Dwight, Wingard John, Wirk Baldeep Mona, Auletta Jeffrey, Lindemans Caroline, Riches Marcie 1 aug 2019, In: Bone Marrow Transplantation. 54 , p. 1354-1360 7 p.

Recognizing a Non-classical Telomeropathy before Hematopoietic Stem Cell Transplantation in Pediatric Patients:A Case Series

Nederlof Iris, Lindemans Caroline A, Bierings Marc B, Mohseny Alexander B, Bresters Dorine, Bartels Marije aug 2019, In: HemaSphere. 3

Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes

Langenhorst J. B., van Kesteren C., van Maarseveen E. M., Dorlo T. P. C., Nierkens Stefan, Lindemans C. A., de Witte M. A., van Rhenen A., Raijmakers R., Bierings M., Kuball J., Huitema A. D. R., Boelens J. J. 23 jul 2019, In: Blood Advances. 3 , p. 2179-2187 9 p.

Predictors for Autoimmune Cytopenias after Allogeneic Hematopoietic Cell Transplantation in Children

Szanto Celina L, Langenhorst Jurgen, de Koning Coco, Nierkens Stefan, Bierings Marc, Huitema Alwin D R, Lindemans Caroline A, Boelens Jaap J 22 jul 2019, In: Biology of Blood and Marrow Transplantation. 26 , p. 114-122 9 p.

Hematopoietic stem cell transplantation for CD40 ligand deficiency:Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study

Ferrua Francesca, Galimberti Stefania, Courteille Virginie, Slatter Mary Anne, Booth Claire, Moshous Despina, Neven Benedicte, Blanche Stephane, Cavazzana Marina, Laberko Alexandra, Shcherbina Anna, Balashov Dmitry, Soncini Elena, Porta Fulvio, Al-Mousa Hamoud, Al-Saud Bandar, Al-Dhekri Hasan, Arnaout Rand, Formankova Renata, Bertrand Yves, Lange Andrzej, Smart Joanne, Wolska-Kusnierz Beata, Aquino Victor M., Dvorak Christopher C., Fasth Anders, Fouyssac Fanny, Heilmann Carsten, Hoenig Manfred, Schuetz Catharina, Kelečić Jadranka, Bredius Robbert G.M., Lankester Arjan C., Lindemans Caroline A., Suarez Felipe, Sullivan Kathleen E., Albert Michael H., Kałwak Krzysztof, Barlogis Vincent, Bhatia Monica, Bordon Victoria, Czogala Wojciech, Alonso Laura, Dogu Figen, Gozdzik Jolanta, Ikinciogullari Aydan, Kriván Gergely, Ljungman Per, Meyts Isabelle, Boelens Jaap Jan, 1 jun 2019, In: Journal of Allergy and Clinical Immunology. 143 , p. 2238-2253 16 p.

All Research Output (66)