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dr. M. (Monique) Nijhuis Associate Professor

  • Department of Medical Microbiology

M. Nijhuis


Research Programs


Monique Nijhuis studied Molecular Biology and obtained her PhD in 1999 at the University of Utrecht on the investigation of the impact of antiretroviral therapy on HIV fitness. Following postdoctoral research training in respiratory viruses she initiated her own research line and became an associate Professor of Virology at the University Medical Center Utrecht in The Netherlands. She is heading the Translational Virology group which performs research at the interface between fundamental and clinical virology. Her research is centered on (I) Viral entry, transmission and pathogenesis (II) Mechanisms of antiviral resistance and viral evolution and (III) Viral-reservoirs and eradication. Monique Nijhuis was granted by the Netherlands Organization for Scientific Research (NWO) with the VIDI and ASPASIA award. She is a member of the IAS HIV Cure International Scientific Working Group and the scientific advisory board of the Dutch Aidsfonds and associate editor of Retrovirology. She has published over 100 papers in peer-reviewed journals and has guided technicians, PhD student, and Postdoctoral Fellows. 

She is teaching Virology in the Bachelor Biomedical Sciences and several Master and PhD programs. She has mentored numerous Bachelor and Graduate students. She is heading the Biological Safety Committee supervising several Biosafety Level III laboratories.

Research Output (100)

A trip down memory lane with Retrovirology

Benkirane Monsef, Berkhout Ben, Borrow Persephone, Fassati Ariberto, Fujii Masahiro, Garcia-Martinez J Victor, Margolis D, Nijhuis Monique, Parent Leslie, Strebel Klaus, Venter François, Kirchhoff Frank, Lever Andrew, Ross Susan, Mak Johnson 21 aug 2019, In: Retrovirology. 16 , p. 22 3 p.

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

Gupta Ravindra K., Abdul-Jawad Sultan, McCoy Laura E., Mok Hoi Ping, Peppa Dimitra, Salgado Maria, Martinez-Picado Javier, Nijhuis Monique, Wensing Annemarie M.J., Lee Helen, Grant Paul, Nastouli Eleni, Lambert Jonathan, Pace Matthew, Salasc Fanny, Monit Christopher, Innes Andrew J., Muir Luke, Waters Laura, Frater John, Lever Andrew M.L., Edwards Simon G., Gabriel Ian H., Olavarria Eduardo 11 apr 2019, In: Nature. 568 , p. 244-248 5 p.

Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

Verheyen Jens, Thielen Alexander, Lübke Nadine, Dirks Miriam, Widera Marek, Dittmer Ulf, Kordelas Lambros, Däumer Martin, De Jong Dorien C.M., Wensing Annemarie M.J., Kaiser Rolf, Nijhuis Monique, Esser Stefan 15 feb 2019, In: Clinical Infectious Diseases. 68 , p. 684-687 4 p.

All-printed cell counting chambers with on-chip sample preparation for point-of-care CD4 counting

Wasserberg Dorothee, Zhang Xichen, Breukers Christian, Connell Bridgette J., Baeten Ellen, van den Blink Dorine, Solà Benet Èlia, Bloem Andries C., Nijhuis Monique, Wensing Annemarie M.J., Terstappen Leon W.M.M., Beck Markus 15 okt 2018, In: Biosensors and Bioelectronics. 117 , p. 659-668 10 p.

The antiretroviral CCR5-inhibitor maraviroc effectively reverses HIV latency by phosphorylation of Nf-kappa B

Symons J., vanLelyveld S. F. L., deSpiegelaere W., Wensing A. M. J., Zerbato J. M., vanHam P. M., Drylewicz J., Middel A., Hoepelman A. I. M., Cameron P. U., Lu H. K., Dantanarayana A. I., Borghans J. A. M., Vandekerckhove L., Lewin S. R., Tesselaar K., Nijhuis M. jul 2018, In: Journal of the International AIDS Society [E]. 21 , p. 29-30

A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape

Lebbink Robert Jan, de Jong Dorien C M, Wolters Femke, Kruse Elisabeth M, van Ham Petra M, Wiertz Emmanuel J H J, Nijhuis Monique 8 feb 2017, In: Scientific Reports. 7

HIV protease inhibitor resistance

Wensing Annemarie M.J., Fun Axel, Nijhuis Monique 1 jan 2017, p. 567-602 36 p.

High rates of transmission of drug-resistant HIV in Aruba resulting in reduced susceptibility to the WHO recommended first-line regimen in nearly half of newly diagnosed HIV-infected patients

Hofstra L. Marije, Rivas Elena Sánchez, Nijhuis Monique, Bank Leonie E.A., Wilkinson Eduan, Kelly Karina, Mudrikova Tania, Schuurman Rob, De Oliveira Tulio, De Kort Jaclyn, Wensing Annemarie M.J. 2017, In: Clinical Infectious Diseases. 64 , p. 1092-1097 6 p.

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

van Diemen Ferdy R., Kruse Elisabeth M., Hooykaas Marjolein J G, Bruggeling Carlijn E., Schürch Anita C., van Ham Petra M., Imhof Saskia M., Nijhuis Monique, Wiertz Emmanuel J H J, Lebbink Robert Jan 1 jun 2016, In: PLoS Pathogens. 12

The presence of protective cytotoxic T lymphocytes does not correlate with shorter lifespans of productively infected cells in HIV-1 infection

Spits Hilde B, Mudrikova Tania, Schellens Ingrid M M, Wensing Annemarie M J, Prins Jan M, Feuth Thijs, Spierings Erik, Nijhuis Monique, van Baarle Debbie, Borghans José A M 2 jan 2016, In: AIDS. 30 , p. 9-17 9 p.

All Research Output (100)
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