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prof. dr. W. (Wiepke) Cahn Full Professor

  • Psychiatry

W. Cahn


Research Programs


Prof. Wiepke Cahn has been a research psychiatrist at the University Medical Center Utrecht since 1996. In 2003 she obtained her PhD titled ‘brain morphology during the early course of schizophrenia’. She has set up various (multicenter) research projects, including GROUP. She has been chief psychiatrist for the schizophrenia program at the UMCUtrecht and project manager for the Utrecht Youth Cohort. Currently she is heading the ‘body & life’ clinic at the department of psychiatry. In 2016 she was appointed professor of psychiatry. Her research interest is the physical (ill-)health in psychiatric disorders.

Wiepke Cahn is vice-president of the Dutch Psychiatric Association. She has authored more than 200 papers and book chapters and has been chief editor of ‘handboek schizofrenie’. Her non-research-based activities consist of treating patients and their families with psychotic and bipolar disorders.

Research Line

Physical health in psychiatric disorders

Most recent key publications

  1. Liemburg EJ, Bruins J, van Beveren N, Islam MA, Alizadeh BZ; GROUP investigators. Cannabis and a lower BMI in psychosis: What is the role of AKT1? Schizophr Res. 2016 Oct;176(2-3):95-9.
  2. de Nijs J, Pet MA; GROUP Investigators.. Metabolic syndrome in schizophrenia patients associated with poor premorbid school performance in early adolescence. Acta Psychiatr Scand. 2016 Apr;133(4):289-97.
  3. Scheewe TW, Backx FJ, Takken T, Jörg F, van Strater AC, Kroes AG, Kahn RS, Cahn W. Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial. Acta Psychiatr Scand. 2013 Jun;127(6):464-73.
  4. Welie H, Derks EM, Verweij KH, de Valk HW, Kahn RS, Cahn W. The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. Schizophr Res. 2013 Feb;143(2-3):354-7.
  5. Cahn W, Ramlal D, Bruggeman R, de Haan L, Scheepers FE, van Soest MM, Assies J, Slooff CJ. [Prevention and treatment of somatic complications arising from the use of antipsychotics]. Tijdschr Psychiatr. 2008;50(9):579-91.


Side Activities

  • GGz Breburg Supervisory Board

    Full Professor, Altrecht Science

Fellowship and Awards

    • Genetic Risk and Outcome of Psychosis (GROUP project) – i.s.m. AMC, UMCG en Universiteit van Maastricht
    • Topfit project – i.s.m. met sportgeneeskunde
    • GRUMPY or Depressed – i.s.m. de sociale faculteit UU
    • Adding in- and outpatient parmacotherapeutic treatment information – i.s.m. de faculteit farmaceutische wetenschappen
    • International panel study on the appropriate pharmacological management of early schizophrenia – RAND/UCLA study

Research Output (117)

Evolutionary modifications in human brain connectivity associated with schizophrenia

van den Heuvel Martijn P, Scholtens Lianne H, de Lange Siemon C, Pijnenburg Rory, Cahn Wiepke, van Haren Neeltje E M, Sommer Iris E, Bozzali Marco, Koch Kathrin, Boks Marco P, Repple Jonathan, Pievani Michela, Li Longchuan, Preuss Todd M, Rilling James K 14 nov 2019, In: Brain : a journal of neurology. 142 , p. 3991-4002 12 p.

Prevalence of metabolic syndrome and its associated risk factors in an African–Caribbean population with severe mental illness

de Caluwé Laura, van Buitenen Nora, Gelan Petra J., Crunelle Cleo L., Thomas Roeland, Casseres Sharon, Matthys Frieda, van Harten Peter, Cahn Wiepke 1 nov 2019, In: Psychiatry Research. 281


Lin Bochao, Alkema Anne, Zinkstok Janneke, Lars Libuda, Hebebrand Johannes, Antel Jochen, Hinney Anke, Cahn Wiepke, Roger Adan, Luykx Jurjen okt 2019, In: European Neuropsychopharmacology. 29 , p. S211-S211

Assessing causal links between metabolic traits, inflammation and schizophrenia:a univariable and multivariable, bidirectional Mendelian-randomization study

Lin Bochao D., Alkema Anne, Peters Triinu, Zinkstok Janneke, Libuda Lars, Hebebrand Johannes, Antel Jochen, Hinney Anke, Cahn Wiepke, Adan Roger, Luykx Jurjen J. 31 aug 2019, In: International Journal of Epidemiology. 48 , p. 1505-1514 10 p.

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

Mullins Niamh, Bigdeli Tim B, Børglum Anders D, Coleman Jonathan R I, Demontis Ditte, Mehta Divya, Power Robert A, Ripke Stephan, Stahl Eli A, Starnawska Anna, Anjorin Adebayo, Corvin Aiden, Sanders Alan R, Forstner Andreas J, Reif Andreas, Koller Anna C, Świątkowska Beata, Baune Bernhard T, Müller-Myhsok Bertram, Penninx Brenda W J H, Pato Carlos, Zai Clement, Rujescu Dan, Hougaard David M, Quested Digby, Levinson Douglas F, Binder Elisabeth B, Byrne Enda M, Agerbo Esben, Streit Fabian, Mayoral Fermin, Bellivier Frank, Degenhardt Franziska, Breen Gerome, Morken Gunnar, Turecki Gustavo, Rouleau Guy A, Grabe Hans J, Völzke Henry, Jones Ian, Giegling Ina, Agartz Ingrid, Melle Ingrid, Lawrence Jacob, Walters James T R, Strohmaier Jana, Boks Marco, Kahn René S, Ophoff Roel A, Cahn Wiepke, 5 jun 2019, In: American Journal of Psychiatry. 176 , p. 651-660 10 p.

Community housing: functional outcome of severe mental illness is associated with the personality traits of the case manager

Lodder Mandy, Schrijvers A. J. P., de Leeuw J. R. J., Brouwer R. M., Cahn W. 3 jun 2019, In: HOUSING CARE AND SUPPORT. 22 , p. 106-113 8 p.

High levels of several antipsychotics and antidepressants due to a pharmacogenetic cause:A case report

Mian Paola, Somers Metten, Berg Maarten Ten, Cahn Winnie, Wilting Ingeborg, Schaik Ron Van jun 2019, In: Pharmacogenomics. 20 , p. 567-570 4 p.

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Harold Denise, Connolly Siobhan, Riley Brien P., Kendler Kenneth S., McCarthy Shane E., McCombie William R., Richards Alex, Owen Michael J., O'Donovan Michael C., Walters James, Donnelly Peter, Bates Lesley, Barroso Ines, Blackwell Jenefer M., Bramon Elvira, Brown Matthew A., Casas Juan P., Corvin Aiden, Deloukas Panos, Duncanson Audrey, Jankowski Janusz, Markus Hugh S., Mathew Christopher G., Palmer Colin N. A., Plomin Robert, Rautanen Anna, Sawcer Stephen J., Trembath Richard C., Viswanathan Ananth C., Wood Nicholas W., Spencer Chris C. A., Band Gavin, Bellenguez Celine, Freeman Colin, Hellenthal Garrett, Giannoulatou Eleni, Hopkins Lucinda, Pirinen Matti, Pearson Richard, Strange Amy, Su Zhan, Vukcevic Damjan, Langford Cordelia, Hunt Sarah E., Edkins Sarah, Gwilliam Rhian, Blackburn Hannah, Bumpstead Suzannah J., Cahn Wiepke, Van Os Jim apr 2019, In: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 180 , p. 223-231

Physical activity and cardiorespiratory fitness in schizophrenia and the associations with mental and physical health

Cahn W., Scheewe T., Jorg F., Takken T., Deenik J., Vancampfort D., Backx F. apr 2019, In: European Psychiatry. 56 , p. S622-S623


Gangadin Shiral, Cahn Wiepke, Scheeuwe Thomas, Pol Hilleke Hulshoff, Bossong Matthijs apr 2019, In: Schizophrenia Bulletin. 45 , p. S288-S288

All Research Output (117)
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