Wij zijn onze website aan het vernieuwen.

Ontdekt u nog een pagina die niet klopt of hebt u een goede suggestie, laat het ons dan weten via webmedia@umcutrecht.nl.

Deze website maakt gebruik van cookies

Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Lees meer over het cookiebeleid.

dr. F. (Floris) Groenendaal Associate Professor - medical

  • Birth Center Neonatology - Medical

F. Groenendaal


Research Programs


Floris Groenendaal finished Medical School of the Erasmus University Rotterdam in 1984. From 1984 1986 he worked at the Institute of Physiology I (Neurophysiology) of the Erasmus University Rotterdam and defended his PhD thesis: "Perinatal hypoxia and visual functions in infants and children" in January 1988. From 1986 to 1991 he was trained in paediatrics in the Sophia Children’s Hospital in Rotterdam. His fellowship neonatology was spent at the Sophia Children’s Hospital, Rotterdam, and the Wilhelmina Children’s Hospital, Utrecht.

Since April 1993 he is consultant neonatology at the Wilhelmina Children’s Hospital/University Medical Center, Utrecht, The Netherlands. At present he is associate professor of neonatology.

In 1994 he was funded by the Ter Meulen Fund to spend his post-doc period at the Department of Physiology of the University of Pennsylvania, Philadelphia, USA. The main focus of his scientific research is: early detection of neonatal brain injury (including MR techniques) and neuroprotection. Under his guidance hypothermia was introduced as standard therapy for neonates with perinatal asphyxia in the Netherlands in 2008. Meanwhile, in collaboration with the NIDOD laboratory of the UMC Utrecht novel therapeutic  strategies have been developed and tested in animal models.

He has been involved in many PhD studies, and has obtained grants from different sources. Publications cited in PubMed include more than 250 papers.

He is member of many professional societies.

Research line

Neonatal neuroprotection

Most recent key publications

1: Harteman JC et al. Diffusion-weighted imaging changes in cerebral watershed distribution following neonatal encephalopathy are not invariably associated with an adverse outcome. Dev Med Child Neurol. 2013;55:642-53
2: Harteman JC et al. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury. J Pediatr. 2013;163:968-95
3: Van den Heuvel MP et al. The Neonatal Connectome During Preterm Brain Development. Cereb Cortex. 2015;25:3000-13
4: Kersbergen K et al. Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. Neuroimage. 2014;103:214-24
5: Alderliesten T et al. Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets. PLoS One. 2014;9:e113575

Side Activities

  • •          Invited speaker on many international courses and symposia

    •          Co-inventor of 2-iminobiotin for neonatal neuroprotection

    •          Expert witness in several legal cases

    •          Reviewer for many international scientific journals

Fellowship and Awards

  • - Ter Meulen Fonds, KNAW, Amsterdam 1993

    - Sterproject Neurowetenschappen Universitair Medisch Centrum Utrecht 1995

    - NWO AGIKO-stipendium 920-03-039

    - Hersenstichting Nederland (Brain Foundation of the Netherlands) 10F02.07

    - Dr.W.M.Phelps-Stichting voor Spastici 03.016

    - Wilhelmina Kinderziekenhuis Onderzoekfonds 2003

    - NWO ZonMW Doelmatigheidsonderzoek ‘Selection of preterm neonates at risk for neurodevelopmental disorders by segmentation of the brain using MRI’ 945-27-022

    - Excellence in Academic Medicine, UniversityMedicalCenter Utrecht 2009-2010.

    - NWO ZonMW Priority Medicines For Children: Pharmacokinetics and Pharmacodynamics of Medication in Asphyxiated Newborns During Controlled Hypothermia. PharmaCoolNationalMulticenter Study. 40-41500-98-9002

    - NWO ZonMW Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain 40-41400-98-1103

    - ZonMW 2012: Organisatie en evaluatie van het perinataal Regio Consortium Utrecht: een samenwerkingsverband voor zorg en kennisoverdracht rondom zwangerschap en geboorte project: 50-50200-98-005

    - ZonMW 2012: Towards risk-guided intergrated and tailored care; Early prediction of pregnancy complications to improve perinatal outcomes.  50-50200-98-060

Research Output (459)

Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy

Annink Kim, V, Groenendaal Floris, Cohen Daan, van der Aa Niek E., Alderliesten Thomas, Dudink Jeroen, Benders Manon J. N. L., Wijnen Jannie P. 2 jan 2020, In: Pediatric Research. 6 p.

Periventricular Hemorrhagic Infarction in Very Preterm Infants:Characteristic Sonographic Findings and Association with Neurodevelopmental Outcome at Age 2 Years

Cizmeci Mehmet N, de Vries Linda S, Ly Linh G, van Haastert Ingrid C, Groenendaal Floris, Kelly Edmond N, Traubici Jeffrey, Whyte Hilary E, Leijser Lara M 6 nov 2019, In: The Journal of Pediatrics. 217 , p. 79-85.e1

Signal Change in the Mammillary Bodies after Perinatal Asphyxia

Molavi M, Vann S D, de Vries L S, Groenendaal F, Lequin M 6 nov 2019, In: American Journal of Neuroradiology. 40 , p. 1829-1834 6 p.

Brain Activity and Cerebral Oxygenation After Perinatal Arterial Ischemic Stroke Are Associated With Neurodevelopment

Wagenaar Nienke, van den Berk Daphne J. M., Lemmers Petra M. A., van der Aa Niek E., Dudink Jeroen, van Bel Frank, Groenendaal Floris, de Vries Linda S., Benders Manon J. N. L., Alderliesten Thomas 8 aug 2019, In: Stroke. 50 , p. 2668-2676 9 p.

Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia

Favié Laurent M.A., Groenendaal Floris, Van Den Broek Marcel P.H., Rademaker Carin M.A., De Haan Timo R., Van Straaten Henrica L.M., Dijk Peter H., Van Heijst Arno, Simons Sinno H.P., Dijkman Koen P., Rijken Monique, Zonnenberg Inge A., Cools Filip, Zecic Alexandra, Van Der Lee Johanna H., Nuytemans Debbie H.G.M., Van Bel Frank, Egberts Toine C.G., Huitema Alwin D.R. 28 jun 2019, In: Neonatology. 116 , p. 154-162 9 p.

The CHOPIn Study:a Multicenter Study on Cerebellar Hemorrhage and Outcome in Preterm Infants

Boswinkel V., Steggerda S. J., Fumagalli M., Parodi A., Ramenghi L. A., Groenendaal F., Dudink J., Benders M. N., Knol R., de Vries L. S., van Wezel-Meijler G. 27 jun 2019, In: Cerebellum (London, England). 18 , p. 989-998 10 p.

Diffusion of the Corpus Callosum in Young Infants

Groenendaal Floris 6 jun 2019, In: Neuropediatrics. 50 , p. 410 1 p.

Neurodevelopmental Outcomes in Preterm Infants with White Matter Injury Using a New MRI Classification

Martinez-Biarge Miriam, Groenendaal Floris, Kersbergen Karina J, Benders Manon J N L, Foti Francesca, van Haastert Ingrid C, Cowan Frances M, de Vries Linda S 20 mei 2019, In: Neonatology. 116 , p. 227-235 9 p.

The risk of intrapartum/neonatal mortality and morbidity following birth at 37 weeks of gestation:a nationwide cohort study

Eskes M, Ensing S, Groenendaal F, Abu-Hanna A, Ravelli A C J 4 apr 2019, In: BJOG - An International Journal of Obstetrics and Gynaecology. 126 , p. 1252-1257 6 p.

External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort

Lamain-de Ruiter Marije, Kwee Anneke, Naaktgeboren Christiana A, Louhanepessy Rebecca D, De Groot Inge, Evers Inge M, Groenendaal Floris, Hering Yolanda R, Huisjes Anjoke J M, Kirpestein Cornel, Monincx Wilma M, Schielen Peter C J I, Van 't Zelfde Annewil, Van Oirschot Charlotte M, Vankan-Buitelaar Simone A, Vonk Mariska A A W, Wiegers Therese A, Zwart Joost J, Moons Karel G M, Franx Arie, Koster Maria P H 20 mrt 2019, In: Hypertension in Pregnancy. 38 , p. 78-88 11 p.

All Research Output (459)
To top