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prof. dr. G. (Gerard) Pasterkamp Full Professor

  • Department of Clinical Chemistry and Haematology
  • Division Board

G. Pasterkamp

Contact

Research Programs

Biography

Gerard Pasterkamp, MD, is professor Experimental Cardiology and scientific medical manager of the division LAB. UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Side Activities

  • Editorial scientific board ATVB, Cardiovascular research, Atherosclerosis, Eur J Cardiovascular Pharmacology

    Board member of Dutch Atherosclerosis Society

    Review board LS7 EU-ERC advanced grants

     

Research Output (375)

Validation of randomized controlled trial-derived models for the prediction of postintervention outcomes in chronic limb-threatening ischemia

Wijnand Joep G J, van Koeverden Ian D, Teraa Martin, Spreen Marlon I, Mali Willem P T M, van Overhagen Hans, Pasterkamp Gerard, de Borst Gert J, Conte Michael S, Gremmels Hendrik, Verhaar Marianne C 1 mrt 2020, In: Journal of Vascular Surgery. 71 , p. 869-879 11 p.

The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular Diseases

Bosch Lena, de Haan Judith J., Seijkens Tom T.P., van Tiel Claudia M., Brans Maike A.D., Pasterkamp Gerard, Lutgens Esther, de Jager Saskia C.A. 1 feb 2020, In: International Journal of Cardiology. 300 , p. 220-220 1 p.

Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac:the Aneurysm-Express Biobank Cohort

van Laarhoven Constance J.H.C.M., van Setten Jessica, van Herwaarden Joost A., Pasterkamp Gerard, de Kleijn Dominique P.V., de Borst Gert J., van der Laan Sander W. 27 dec 2019, In: Scientific Reports. 9

A Pro-Inflammatory Biomarker-Profile Predicts Amputation-Free Survival in Patients with Severe Limb Ischemia

Gremmels Hendrik, Teraa Martin, de Jager Saskia C.A., Pasterkamp Gerard, de Borst Gert J., Verhaar Marianne C. 1 dec 2019, In: Scientific Reports. 9

A head-to-head comparison of conjugation methods for VHHs:Random maleimide-thiol coupling versus controlled click chemistry

van Moorsel Marc V.A., Urbanus Rolf T., Verhoef S., Koekman C. A., Vink Maurice, Vermonden T., Maas Coen, Pasterkamp Gerard, Schiffelers Raymond M. 1 dec 2019, In: International Journal of Pharmaceutics: X. 1

Magnetic Resonance Imaging Identified Brain Ischaemia in Symptomatic Patients Undergoing Carotid Endarterectomy Is Related to Histologically Apparent Intraplaque Haemorrhage

Rots Marjolijn L., Timmerman Nathalie, de Kleijn Dominique P.V., Pasterkamp Gerard, Brown Martin M., Bonati Leo H., de Borst Gert J. 1 dec 2019, In: European Journal of Vascular and Endovascular Surgery. 58 , p. 796-804 9 p.

Effect of vagus nerve stimulation on tissue damage and function loss in a mouse myocardial ischemia-reperfusion model

Nederhoff M. G.J., Fransen D. E., Verlinde S. A.M.W., Brans M. A.D., Pasterkamp G., Bleys R. L.A.W. 1 nov 2019, In: Autonomic Neuroscience: Basic and Clinical. 221

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

Frodermann Vanessa, Rohde David, Courties Gabriel, Severe Nicolas, Schloss Maximilian J., Amatullah Hajera, McAlpine Cameron S., Cremer Sebastian, Hoyer Friedrich F., Ji Fei, van Koeverden Ian D., Herisson Fanny, Honold Lisa, Masson Gustavo Santos, Zhang Shuang, Grune Jana, Iwamoto Yoshiko, Schmidt Stephen P., Wojtkiewicz Gregory R., Lee I. Hsiu, Gustafsson Karin, Pasterkamp Gerard, de Jager Saskia C.A., Sadreyev Ruslan I., MacFadyen Jean, Libby Peter, Ridker Paul, Scadden David T., Naxerova Kamila, Jeffrey Kate L., Swirski Filip K., Nahrendorf Matthias 1 nov 2019, In: Nature Medicine. 25 , p. 1761-1771 11 p.

Corrigendum to: Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure (vol 279, pg 141, 2019)

Bosch Lena, de Haan Judith J., Seijkens Tom T.P., van Tiel Claudia M., Brans Maike A.D., Pasterkamp Gerard, Lutgens Esther, de Jager Saskia C.A. 15 okt 2019, In: International Journal of Cardiology. 293 , p. 297-297 1 p.

Preoperative hypertension is associated with atherosclerotic intraplaque hemorrhage in patients undergoing carotid endarterectomy

Fassaert Leonie M.M., Timmerman Nathalie, van Koeverden Ian D., Pasterkamp Gerard, de Kleijn Dominique P.V., de Borst Gert J. 22 sep 2019, In: Atherosclerosis. 290 , p. 214-221 8 p.

All Research Output (375)
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