Group Bos

Prof.Dr. Hans Bos Professor of Molecular Cancer Research

Telephone number: +31 (0)88 75 68989

E-mail address: j.l.bos@umcutrecht.nl

Areas of expertise uitklapper, klik om te openen

Since his PhD in the lab of Piet Borst (1980), Johannes (Hans) Bos has studied the molecular cause of cancer. Initially in the lab of Alex van der Eb in Leiden, using adenovirus 12, a virus that can form tumors in rodents. In 1984 he started to work on Ras mutations in human tumors. He could demonstrate that such mutations occur frequently in many tumor types. After a sabbatical year in San Francisco with Frank McCormick he moved to Utrecht in 1991 to become professor in Molecular Cancer Research and to work on the function of the Ras protein. In 1994 he started to work on the small GTPase Rap, leading to the discovery of the cAMP target Epac. More recently, he joined forces with Hans Clevers, to study Ras in patient-derived tumor organoids. From 2007-2015 he was chair of the Divison Biomedical Genetics and head of the Department Molecular Cancer Research. Currently he chairs of the UMCU priority program Cancer. In 2014 he received the prestigious Josephine Nefkens prize for Cancer Research.

Research program / group uitklapper, klik om te openen

Current research focuses on three topics:
1. The function of the small GTPase Rap1 and the cAMP regulated guanine nucleotide exchange factor Epac in the control of cell adhesion.
2. The mechanism of brush border formation and apical membrane formation in intestinal epithelial cells
3. Targeted therapies for mutant Ras containing colorectal cancer

 
Group members

• Fried Zwartkruis - Associate Professor
• Lucas Bruurs - PhD student
• Susan Zwakenberg - Technician
• Marianne van der Heiden - Administrative Assistant
• Ester Frische - Senior Processmanager

Key publications uitklapper, klik om te openen

• Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL. ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization. J. Cell Biol. 2015, 210, 1055-63.
• Post A., Pannekoek, W.-J., Ross, S.H., Verlaan, I., Brouwer, P.M. and Bos, J.L. Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29. Proc. Natl. Acad. Sci. 2013, 110, 11427-11432
• Gloerich M., Ten Klooster J.P., Vliem M.J., Koorman T., Zwartkruis F.J., Clevers H., Bos JL. Rap2A links intestinal cell polarity to brush border formation. Nat. Cell. Biol. 2012 , 14, 793-801
• Consonni SV, Gloerich M, Spanjaard E, Bos JL. cAMP regulates DEP-domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane. Proc. Natl. Acad. Sci. 2012, 109, 3814-3819.
• Gloerich M, Vliem MJ, Prummel E, Meijer LAT, Rensen MGA, Rehmann H, Bos JL. The nucleoporin RanBP2 tethers the cAMP effector Epac1 resulting in the inhibition of Epac1 catalytic activity. J. Cell Biol. 2011, 193:1009-1020.

Link to full list of publications

More contact information uitklapper, klik om te openen

Visiting address:
Universiteitsweg 100,
3584 CG Utrecht,
The Netherlands

Secretariat:
Marianne van der Heiden
A.M.vanderHeiden@umcutrecht.nl
+31 88 75 68989