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Data science in general, and artificial intelligence (AI) including machine learning in particular, will fundamentally transform society, including the healthcare sector. AI is expected to become an integral part of our daily health, healthcare, health research, and health education. It will impact everyone: patients, citizens, employees, teachers, and students. Diagnosis, prognosis, prevention, treatment, monitoring and screening of health and diseases will all be impacted. For the UMC Utrecht, this means that the way of working, doing research and providing education will change significantly. Data Science and AI will therefore become a focus of our health(care) research and education in the coming era.