Neuro-Immunology of pain - Group Eijkelkamp
Neuro-immunology of pain
About uitklapper, klik om te openen
Chronic pain affects ~20% of the population and is difficult to treat. To identify potential novel pain treatments we need deeper understanding of the mechanisms that drive chronic pain. We are interested in the neurobiology of chronic pain and focus primarily on interactions between the immune system and the sensory nervous system. By understanding which neuro-immune interactions are important contributors to chronic pain development, we aim to identify and develop new highly needed therapeutics to treat painful conditions. We perform fundamental research and aim to translate our research into the clinic by collaborating with scientists and clinicians.
Research programs uitklapper, klik om te openen
Infection and Immunity
Child Health
Research interests uitklapper, klik om te openen
- Immune cells contributing to resolution and maintenance of pain
- Development of fusion proteins of regulatory cytokines for the treatment of chronic pain
- Mitochondria in regulating neuronal homeostasis and pain.
- Bonepain: Mechanisms of Osteoarthritis (OA) and bone cancer induced pain
- Neuropathy in diabetes Mellitus
- Biomarkers and predictors of OA and juvenile idiopathic arthritis pain
Group members uitklapper, klik om te openen
Group leader
dr. N. Eijkelkamp
Associate Professor
Postdocs
Hanneke Willemen
Huiying Yeoh
Leire Almandoz Gil
Senior researcher
Judith Prado
Research technicians
Sabine Versteeg
Fanny Boisnard
PhD students
Mohammed Asiri
Christian Martin Gil
Maarten Mensink
Patricia Ribeiro
Students
Lucie Groenendaal
Annefien Tiggeler
Key publications uitklapper, klik om te openen
- Willemen HLDM, Kavelaars A, Prado J, Maas M, Versteeg S, Nellissen LJJ, Tromp J, Cano RG, Zhou W, Jakobsson ME, Malecki J, Posthuma G, Habib AM, Heijnen CJ, Falnes ØP, Eijkelkamp N. Identification of FAM173B as a protein methyltransferase promoting chronic pain. Plos Biology, 2018. View
- Raoof R, Willemen HLDM, Eijkelkamp N. Divergent roles of immune cells and their mediators in pain. Rheumatology, 2017. View
- Eijkelkamp N, Steen-Louws C, Hartgring SA, Willemen HLDM, Prado J, Lafeber FP, Heijnen CJ, Hack CE, van Roon JA, Kavelaars A. IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain. J. Neurosci, 2016. View
- Eijkelkamp N, Linley JE, Torres JM, Bee L, Dickenson AH, Gringhuis M, Minett MS, Hong GS, Lee E, Oh U, Ishikawa Y, Zwartkuis FJ, Cox JJ, Wood JN. A role for Piezo2 in EPAC1-dependent mechanical allodynia. Nat Commun. 2013;4:1682. View
PHD theses uitklapper, klik om te openen
Uterine immunovascular adaptations in early pregnancy
Emiel Post Uiterweer
2015
Chronic inflammatory pain: new molecules and mechanisms
Hanneke Willemen
2013
GRK2 and chronic pain
Huijing Wang
2012
Grants uitklapper, klik om te openen
- CUCo: Centre for unusual collaborations
- Healt Holland
- NWO: TTW
- NWO: VENI
- UU: 3V's
- EU BonePain network
- ReumaNederland
- KACST
Prizes uitklapper, klik om te openen
- Congress of the European Pain Federation Financial aid to attend the congress in Valencia - Mohammed Asiri (2019)
- 17th World Congress on Pain Financial aid to attend the congress in Boston - Ramin Raoof (2018)
- Bright Sparks Award Ramin Raoof 2018
- The Challenge of Chronic Pain Conferences Bursary to attend the conferences in Cambridge - Ramin Raoof (2017)
- EMBO short term fellowship Travel Grant Hanneke Willemen (2014)
- Boehringer Ingelheim Fonds Travel Grant Hanneke Willemen (2013)
In the media uitklapper, klik om te openen
29 Aug 2019: Op zoek naar de oorzaken van pijn bij artrose - ReumaNederland nieuws
20 Mar 2019: Naar een effectieve behandeling van chronische pijn - De Instantie voor Dierenwelzijn Utrecht
16 Jul 2018: Veni-subsidie voor 22 jonge Utrechtse wetenschappers - Utrecht University Nieuws
14 Sep 2016: Team van onderzoekers werkt aan volgende fase medicijn synerkine - ReumaNederland nieuws
28 Jul 2013: Nieuwe kijk op chronische pijn - Hanneke Willemen for MEDNET
Collaborations uitklapper, klik om te openen
University Medical Center Utrecht
Dr. Linde Meyaard & Dr. Michiel v/d Vlist
Dr. Jeanette Leusen
Dr. Jo Hoppener
Dr. Floris Lafeber & Simon Mastbergen
Utrecht University
Dr. Remco Westerink
Abroad
Dr. Pal Falnes, Oslo University, Norway
Dr. Cobi Heijnen & Dr. Annemieke Kavelaars, MD Anderson, Houston, USA
Gallery uitklapper, klik om te openen
Mouse dorsal root ganglion neurons
Nerves innervating the skin
Human dorsal root ganglion neurons
